Prospective Validation of a Composite End Point in Thrombolytic Trials of Acute Myocardial Infarction (TIMI 4 and 5)

Cannon, Christopher P.; Sharis, Peter; Schweiger, Marc J.; McCabe, Carolyn H.; Diver, Daniel J.; Shah, Prediman K.; Sequeira, Rafael F.; Greene, Robert M.; Perritt, Rebecca; Poole, W. Kenneth; Braunwald, Eugene

doi:10.1016/s0002-9149(97)00497-9

Cited by 20 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Event-free survival—which reflects both mortality and hospitalizations—was chosen as the primary end point to capture a more complete picture of disease progress rather than mortality alone 30–32. Monthly follow-up phone calls and hospital administrative databases were reviewed to identify events.…”

Section: Methodsmentioning

confidence: 99%

Depressive symptoms and poor social support have a synergistic effect on event-free survival in patients with heart failure

Chung¹,

Lennie²,

Dekker³

et al. 2011

Heart & Lung

View full text Add to dashboard Cite

Background Depressive symptoms and poor social support are predictors of increased morbidity and mortality in patients with heart failure (HF). However, the combined contribution of depressive symptoms and social support event-free survival of patients with HF has not been examined. Objective To compare event-free survival in four groups of patients with HF stratified by depressive symptoms and perceived social support. Method A total of 220 patients completed the Beck Depression Inventory-II and the Multidimensional Perceived Social Support Scale and were followed for up to 4 years to collect data on death and hospitalizations. Results Depressive symptoms (HR=1.73, P=.008) and perceived social support (PSS) (HR=1.51, P=.048) were independent predictors of event-free survival. Depressed patients with low PSS had 2.1 times higher risk of events than non-depressed patients with high PSS (P=.003). Conclusion Depressive symptoms and poor social support had a negative additive effect on event-free survival in patients with HF.

show abstract

Section: Methodsmentioning

confidence: 99%

Depressive symptoms and poor social support have a synergistic effect on event-free survival in patients with heart failure

Chung¹,

Lennie²,

Dekker³

et al. 2011

Heart & Lung

View full text Add to dashboard Cite

show abstract

“…The benefits, risks, and influence on sample size computation of using CEs have been broadly studied (1,2,6,7,9,13,14). However, to our knowledge, the impact of the strength of the relationship between CE components on such computation has not been addressed in depth (3,4,(15)(16)(17)(18).…”

Section: Pop-up Notesmentioning

confidence: 99%

The Use of a Binary Composite Endpoint and Sample Size Requirement: Influence of Endpoints Overlap

Marsal

Ferreira‐González

Bertran

et al. 2016

American Journal of Epidemiology

View full text Add to dashboard Cite

“…MACE was defined as the composite incidence of death, recurrent infarction, repeat PCI or a LVEF ≤ 30%. The combination of death and non-fatal major events as recurrent infarction, repeat intervention, and heart failure has been shown to be a valid predictor of 1-year mortality [17,18]. If in one patient more than one event occurred, these events accounted for one MACE.…”

Section: Methodsmentioning

confidence: 99%

Untitled

Horst

Nijsten

Vogelzang

et al. 2007

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background: Elevated blood glucose values are a prognostic factor in myocardial infarction (MI) patients. The unfavourable relation between hyperglycemia and outcome is known for admission glucose and fasting glucose after admission. These predictors are single measurements and thus not indicative of overall hyperglycemia. Increased persistent hyperglycemia may better predict adverse events in MI patients.

show abstract

Prospective Validation of a Composite End Point in Thrombolytic Trials of Acute Myocardial Infarction (TIMI 4 and 5)

Cited by 20 publications

References 24 publications

Depressive symptoms and poor social support have a synergistic effect on event-free survival in patients with heart failure

Depressive symptoms and poor social support have a synergistic effect on event-free survival in patients with heart failure

The Use of a Binary Composite Endpoint and Sample Size Requirement: Influence of Endpoints Overlap

Untitled

Contact Info

Product

Resources

About