Prospective trial of intraoperative mitomycin C in the treatment of primary pterygium.

Cano-Parra, J.; Díaz-Llopis, M.; Maldonado, Miguel J.; Vilà, E.; Menezo, J.L.

doi:10.1136/bjo.79.5.439

Cited by 96 publications

(53 citation statements)

References 15 publications

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“…These are (a) Intraoperative topical application of mitomycin-C, an antimetabolite that affectively reduces fibroblastic capillary proliferations at osteotomy site (commonly used by ophthalmologists) in external DCR procedure and also used in EnDCR by otolaryngologists. 17,18 (b) Intraoperative use of nasolacrimal silicone stent to maintain the patency of canaliculi and neo-ostium by preventing post-operative synechiae. 19 (c) Wide exposure of lacrimal sac with marsupialization of lacrimal sac with the nasal mucosa, thereby minimizing the formation of granulation tissue and synechiae.…”

Section: Discussionmentioning

confidence: 99%

A comparative study in the use of topical mitomycin-C versus nasolacrimal stent in endoscopic dacryocystorhinostomy for chronic dacryocystitis

Gupta

Singh

Dwivedi

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Inflammation of the lacrimal sac and duct is a common and unpleasant condition, leading to troublesome epiphora and recurrent dacryocystitis. Surgery is the preferred treatment modality of chronic dacryocystitis which can be performed by external approach or endoscopic nasal approach. Endoscopic dacrycocystorhinostomy (EnDCR) is now a well-established procedure to relieve nasolacrimal duct obstruction, becoming ENT surgeons’ domain. The aim of this study is to assess the efficacy and compare results of intraoperative use of nasolacrimal stent in comparison of mitomycin-C (MMC) in endoscopic dacryocystorhinostomy.Methods: A prospective study of 56 patients with acquired NLDO with epiphora and recurrent dacryocystitis who were evaluated and managed between Oct 2014 and Oct 2016. All patients were offered surgical line of management by endoscopic route. They were randomly assigned into two groups-mitomycin-C group (Group A) and silastic nasolacrimal stenting (Group B). 46 patients who matched inclusion criteria’s were included in the study after formal evaluation by ENT surgeon and Ophthalmologist. 26 patients underwent endoscopic dacryocystorhinostomy with Mitomycin-C application intra – op, 20 patients underwent nasolacrimal silicone stent placement. Results: At 6-month follow-up visit, the management was considered successful if the lacrimal sac irrigation succeeded with relief of symptoms. The success rate in Group A was 92.30%. Group B had 85% success rate. However, no significant (p value=0.37) was noticed between two groups.Conclusions: Despite, no significant difference in outcome between two modalities, there is a trend towards the better outcome with use of mitomycin-C. Mitomycin-C is a safe, effective, and economical adjuvant in endoscopic DCR assisting in improved outcomes of surgery.

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Section: Discussionmentioning

confidence: 99%

A comparative study in the use of topical mitomycin-C versus nasolacrimal stent in endoscopic dacryocystorhinostomy for chronic dacryocystitis

Gupta

Singh

Dwivedi

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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“…Nüks sıklığı %31-89 aralığında değişmektedir (10,11). Bu teknikle beraber Nekrotizan sklerit, granülom formasyonu, ön kamara reaksiyonu, dellen oluşumu, semblefaron, sklerit, keratosklerit ve skleral incelme, korneal perforasyon gibi çeşitli komplikasyonları görmek mümkündür (4,(12)(13)(14) (15). Günümüzde yöntemin uygulamasında peribulber ve subkonjonktival anestezi de kullanılabilmektedir (4,16).…”

Section: Gereç Ve Yöntemlerunclassified

Comparison of different surgical techniques in the treatment of pterygium

Zorlu¹,

Cinar²,

Firinciogullari³

et al. 2012

Gaziantep Med J

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ÖzetÇalışmamızda pterjium cerrahisinde uygulanan farklı cerrahi teknikler arasında nüks oranlarının araştırılması amaçlandı. Çalışmaya ameliyat sonrası en az 6 ay takibi bulunan, 128 hastanın 130 gözü alındı. Hastalara cerrahi yöntem olarak çıplak sklera bırakılması, intraoperatif MMC (Mitomisin C) uygulaması, geniş tenon eksizyonu ve konjonktival otogreft uygulaması yöntemleri uygulandı. Hastaların yaşı, cinsiyeti, takip süreleri, uygulanan cerrahi prosedür, nüks gelişme zamanları ve komplikasyonlar not edildi. Sonrasında hesaplanan nüks oranları istatistiksel olarak analiz edildi. Ortalama 9,42±3,93 ay takip edilen hastaların %25,4'ünde nüks saptandı. En yüksek nüks oranı %55,2 ile çıplak sklera tekniğinde tespit edildi. Konjonktival otogreft uygulamasında %14,6, intraoperatif MMC uygulamasında %13,5, geniş tenon eksizyonunda %31,3 oranında nüks görüldü. Çıplak sklera bırakılması ile konjonktival otogreft uygulaması ve intraoperatif MMC uygulaması arasında nüks açısından anlamlı fark saptanırken, geniş tenon eksizyonu ile diğer 3 yöntem arasında nüks bakımından farklılık saptanmadı. Çıplak sklera bırakılması diğer yöntemlerden yüksek nüks oranlarına sahiptir. Birbirine yakın düşük nüks oranları mevcut olsa da potansiyel komplikasyonlar göz önüne alındığında konjonktival otogreft yöntemi, intraoperatif MMC uygulamasına tercih edilmelidir. Geniş tenon eksizyonunun diğer yöntemlerle kıyaslanması için geniş vaka grupları ile yapılacak çalışmalara ihtiyaç vardır. Anahtar kelimeler: Mitomisin C; nüks; pterjium AbstractThis study was done to compare the rates of recurrence of pterygium following performed different surgical techniques for treatment. One hundred and thirty eyes of 128 patients were examined following the surgical treatment in our clinic between February 2004-January 2008 with mean follow-up of six months. We performed bare sclera, application of intraoperative MMC (Mitomycin C), wide tenon's membrane excision and conjunctival auto-grafting techniques. The age and sex of the patients and follow-up duration, operation techniques, complications and the recurrence times were noted. Median follow-up was 9,42±3,93 months and the recurrence rate was %25,4. The highest recurrence rate was %55,2 (in the bare sclera technique), the lowest recurrence rate was %13,5 (in the intraoperative MMC technique). It was %14,6 in conjunctival auto-grafting technique group and %31,3 in the complete tenon's membrane excision group. Statistically, the rate of recurrence was meaningful between the bare sclera group and the conjunctival autografting group and between intraoperative MMC group. But the outcomes of the wide tenon's membrane excision group and the other three groups weren't meaningful. Bare sclera technique had the highest recurrence rates. Though, there wasn't meaningful recurrence rates between intraoperative MMC technique and the conjunctival auto-grafting technique, we must prefer the second one because of its lowest complication risks. The wide tenon's membrane excision technique needs some more studies to com...

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“…Simple excision combined with adjuvant therapy, such as anti-VEGF agents, or grafts that include amniotic membrane grafts or conjunctival autografts provide the best results for the long-term success of pterygium surgery (5,6).…”

Section: Pterygium Excisionmentioning

confidence: 99%

Updates on the Treatment of Pterygium

Todorović

Vulović

Srećković

et al. 2016

Serbian Journal of Experimental and Clinical Research

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Prospective trial of intraoperative mitomycin C in the treatment of primary pterygium.

Abstract: Ains-A prospective, randomised, double blind, placebo controlled study of intraoperative mitomycin C as adjunctive treatment of primary pterygium was conducted. Methods Conclusion-Intraoperative mitomycin C appears to be an effective and safe adjunctive treatment of primary pterygium.

Cited by 96 publications

References 15 publications

A comparative study in the use of topical mitomycin-C versus nasolacrimal stent in endoscopic dacryocystorhinostomy for chronic dacryocystitis

A comparative study in the use of topical mitomycin-C versus nasolacrimal stent in endoscopic dacryocystorhinostomy for chronic dacryocystitis

Comparison of different surgical techniques in the treatment of pterygium

Updates on the Treatment of Pterygium

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