Prospective survey of childhood inflammatory bowel disease in the British Isles

Sawczenko, A; Sandhu, Bhupinder; Logan, Richard F.; Jenkins, Huw; Taylor, Chris; Mian, Sameera; Lynn, Richard

doi:10.1016/s0140-6736(00)04309-9

Cited by 360 publications

(258 citation statements)

References 5 publications

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“…3,4 While the aetiology of CD remains unknown, it is now clear that gene-environment interactions are central to understanding disease pathogenesis. 5 Detailed evaluation of the susceptibility locus on chromosome 16 has lead to the identification of the inflammatory bowel disease (IBD)1 gene as NOD2 (caspase recruitment domain (CARD)15).…”

Section: Introductionmentioning

confidence: 99%

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

et al. 2004

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Section: Introductionmentioning

confidence: 99%

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

et al. 2004

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“…Paediatric IBD populations may be particularly appropriate to study these patients, as proportionately they contain a larger number of IC patients (up to 30% of total IBD cases) compared to published adult series. 2,38 The research focus thus far in IC patients has been limited to the study of serological rather than genetic markers. 39,40 This is the first study to demonstrate a higher carriage of any NOD2/CARD15 mutation in patients with IC, although we recognise that the number of patients analysed is small (n ¼ 29) and the result may therefore be a false-positive.…”

Section: Regression Analysis Of CD Susceptibility Genes In Scottish Cmentioning

confidence: 99%

“…1 Scotland has the highest incidence of paediatric IBD in the United Kingdom, 2 and one of the highest incidence rates of paediatric CD throughout the world. The aetiology of IBD is complex with data supporting a role for a number of environmental agents and genes.…”

Section: Introductionmentioning

confidence: 99%

Detailed assessment of NOD2/CARD15 exonic variation in inflammatory bowel disease in Scotland: implications for disease pathogenesis

et al. 2008

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The high incidence of Scottish Crohn's disease (CD) is not explained by the common three NOD2/CARD15 variants. We aimed to identify population-specific NOD2/CARD15 coding variants. A total of 1478 (320 inflammatory bowel disease patients o16 years, 343 adult CD patients, 542 parents and 273 controls). All NOD2/CARD15 exons were sequenced in 24 CD patients. Sequencing identified 18 single-nucleotide polymorphisms (SNPs) including 4 non-synonymous coding SNPs altering the structure of the Leucine-rich region-two were well established (1007-/C and 908G/R). Two other variants, valine955isoleucine (955V/I) and methionine863valine (863M/V), were genotyped in all subjects. 863M/V carriage was not significantly higher in CD patients vs controls (1.35 vs 0.37%, P ¼ 0.27). 955V/I carriage was no higher in CD or ulcerative colitis patients (12.8 and 15.8%, respectively) compared to controls (16.2%). Transmission disequilibrium test analysis was negative. 955V/I carriage was higher in indeterminate colitis patients (n ¼ 29) compared to controls (41.4 vs 16.2%, P ¼ 0.001, OR ¼ 3.6 (1.6-8.2)). Population-specific NOD2/CARD15 exonic variants do not account for the high-CD prevalence in Scotland.

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“…3 It is a condition that is most commonly diagnosed during childhood or early adolescence. 4 immune responses. In addition, it can lead to inappropriate Th1 pathway stimulation due to decreased inhibition of the TLR2 stimulation.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease and oral health

Chandan

Thomas

2017

BDJ Team

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Risk factors involved in IBDIBD is thought to result from inappropriate and ongoing activation of the mucosal immune system facilitated by defects in both the intestinal epithelium and mucosal immune system. 5 There are both genetic and environmental factors implicated in the aetiology of IBD. 6 Although traditionally associated with the developed world, recent epidemiological studies suggest an increasing incidence in rapidly developing countries, especially in South-East Asia. 7 In addition, the increased risk of IBD in the immigrant populations in the West suggests environment has a role in the development of IBD. 8 Genetic Detailed genetic mapping has identified specific genetic changes on chromosome 16 carried in families which appear linked to CD, however no significant changes have been mapped as of yet to UC. 9,10 Specifically, variants of the NOD2 gene provide the strongest association with susceptibility to CD. NOD2 plays a key role in regulating the gut mucosal barrier involving, specifically, the microbiota, as well as the related response by the innate and adaptive immune system. The IBDchip European Project showed NOD2 has been implicated in ileal location colitis with stenosing and penetrating disease behaviour. 11 A genome wide association study has also identified a strong link between the IL23R gene and CD. 12 The gene in particular codes for interleukin 23 that plays a role in regulating innate immunity within the intestine. 13 Cigarette smoking Unusually, cigarette smoking is associated with decreased rates of incidence of UC and has been associated with protective features to prevent further flare-ups of the condition 14-19 such as relapses, 20 ©SEBASTIAN KAULITZKI/Science Photo Library/Getty J. S. Chandan 1 and T. Thomas 1 summarise the treatments for inflammatory bowel disease (IBD) and how anti-inflammatory medications can have side effects that affect the oral cavity.

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Prospective survey of childhood inflammatory bowel disease in the British Isles

Cited by 360 publications

References 5 publications

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

Detailed assessment of NOD2/CARD15 exonic variation in inflammatory bowel disease in Scotland: implications for disease pathogenesis

Inflammatory bowel disease and oral health

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