Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections

Pícha, Dušan; Moravcová, Lenka; Smíšková, Dita

doi:10.1016/j.jns.2016.05.059

Cited by 30 publications

(26 citation statements)

References 25 publications

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“…However, most studies measuring CXCL13 using ELISA and lateral flow (LFA) methods have shown elevated CXCL13 circulation levels in the CSF of patients with acute neuroborreliosis compared to other tested groups. Results of the available studies suggest its very high diagnostic value and report its high sensitivity and specificity [5][6][7][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. These studies are in agreement with a meta-analysis performed by Yang J. et al, who confirmed that CXCL13 has a high sensitivity and specificity for diagnosing neuroborreliosis [68].…”

Section: Cxcl13 Concentrationsupporting

confidence: 85%

“…Neuroborreliosis CSF CXCL13 levels are highly elevated in NB compared to healthy and other non-inflammatory CNS diseases [5][6][7][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] CSF CXCL13 levels are significantly elevated in NB in comparison to NS [9,10,12] CSF CXCL13 concentrations are elevated in acute and possible NB with positive specific antibodies against Borrelia burgdorferi [5,34,[37][38][39][40] CSF CXCL13 concentrations correlate with WBC count and disease activity [41,42] CSF CXCL13 concentrations correlate better with pleocytosis than with CSF-specific antibodies [5,34,[37][38][39][40] CSF CXCL13 levels are highly elevated in NB patients with shorter disease duration [41,42] CSF CXCL13 levels are markedly elevated before treatment compared to after treatment [7,28,32,…”

Section: Referencesmentioning

confidence: 99%

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Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Gudowska-Sawczuk

Mroczko

2020

IJMS

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Neuroborreliosis (NB) and neurosyphilis (NS) are abnormal conditions caused by spirochetal bacteria which affect the nervous system. Diagnosis of neuroborreliosis and neurosyphilis is determined by clinical examination of visible symptoms, serum and cerebrospinal fluid (CSF) analysis, and serological detection of antibodies against Borrelia burgdorferi sensu lato and Treponema pallidum, respectively. Establishing a diagnosis may sometimes pose a number of diagnostic difficulties. A potential role of chemokine ligand 13 (CXCL13) as an accurate diagnostic biomarker of intrathecal inflammation has been suggested. In this review, we focused on changes in serum and cerebrospinal fluid concentration of chemokine ligand 13 in selected spirochetal neurological diseases neuroborreliosis and neurosyphilis reported in the available literature. We performed an extensive search of the literature relevant to our investigation via the MEDLINE/PubMed database. It has been proven that CXCL13 determination can provide rapid information regarding central nervous system inflammation in patients with selected spirochetosis. We described that neuroborreliosis and neurosyphilis are associated with an elevated CXCL13 concentration, mainly in the cerebrospinal fluid. Moreover, literature data suggest that CXCL13 determination is the most interesting additional marker for diagnosis and monitoring of neuroborreliosis and neurosyphilis thanks to its high sensitivity. Based on these published findings, we suggest that CXCL13 has high diagnostic utility and may be applied in laboratory diagnostics as a potential diagnostic marker in human spirochetal neurologic diseases.

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Section: Cxcl13 Concentrationsupporting

confidence: 85%

Section: Referencesmentioning

confidence: 99%

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Gudowska-Sawczuk

Mroczko

2020

IJMS

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“…In our opinion, antibiotic treatment in such cases is justified with the important restriction that such a therapy has not been conducted before. The chemokine CXCL13 has been evaluated as a possible CSF biomarker for detection of acute neuroborreliosis [69–71]. CXCL13 analysis might help in such cases to differentiate between acute neuroborreliosis and previous infection.…”

Section: Discussionmentioning

confidence: 99%

Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization

et al. 2017

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BackgroundNeuroborreliosis represents a relevant infectious disease and can cause a variety of neurological manifestations. Different stages and syndromes are described and atypical symptoms can result in diagnostic delay or misdiagnosis. The aim of this retrospective study was to define the pivotal neurological deficits in patients with neuroborreliosis that were the reason for admission in a hospital.MethodsWe retrospectively evaluated data of patients with neuroborreliosis. Only patients who fulfilled the diagnostic criteria of an intrathecal antibody production against Borrelia burgdorferi were included in the study.ResultsSixty-eight patients were identified with neuroborreliosis. Cranial nerve palsy was the most frequent deficit (50%) which caused admission to a hospital followed by painful radiculitis (25%), encephalitis (12%), myelitis (7%), and meningitis/headache (6%). In patients with a combination of deficits, back pain was the first symptom, followed by headache, and finally by cranial nerve palsy. Indeed, signs of meningitis were often found in patients with neuroborreliosis, but usually did not cause admission to a hospital. Unusual cases included patients with sudden onset paresis that were initially misdiagnosed as stroke and one patient with acute delirium. Cerebrospinal fluid (CSF) analysis revealed typical changes including elevated CSF cell count in all but one patient, a blood-CSF barrier dysfunction (87%), CSF oligoclonal bands (90%), and quantitative intrathecal synthesis of immunoglobulins (IgM in 74%, IgG in 47%, and IgA in 32% patients). Importantly, 6% of patients did not show Borrelia specific antibodies in the blood.ConclusionIn conclusion, the majority of patients presented with typical neurological deficits. However, unusual cases such as acute delirium indicate that neuroborreliosis has to be considered in a wide spectrum of neurological diseases. CSF analysis is essential for a reliable diagnosis of neuroborreliosis.

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“…При раннем нейроборрелиозе чувствитель-ность ПЦР-исследования ЦСЖ составляет примерно 40%, в то время как при позднем нейроборрелиозе -25% [2,9,22,29]. В биоптатах кожи (больных с МЭ или ак-родерматитами) или синовиальной жидкости (больных с Лайм-артритами) ДНК выявляется в 50-75%, чувствитель-ность выше при исследовании синовиальной жидкости.…”

Section: лабораторная диагностика икбunclassified

“…Однако диагностическая ценность этих мето-дов исследована недостаточно, и они не могут быть реко-мендованы для рутинной лабораторной диагностики [7,8,22,[29][30][31].…”

Section: лабораторная диагностика икбunclassified

Current State of Tick-Borne Borreliosis (Lyme Disease) in Children

Зверева¹,

Shakaryan²,

Sayfullin³

et al. 2017

Det. infekc.

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Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections

Cited by 30 publications

References 25 publications

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Chemokine Ligand 13 (CXCL13) in Neuroborreliosis and Neurosyphilis as Selected Spirochetal Neurological Diseases: A Review of Its Diagnostic Significance

Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization

Current State of Tick-Borne Borreliosis (Lyme Disease) in Children

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