During high-speed seeding operations, collisions between seeds and seed guide tubes are very significant, resulting in poor seed spacing uniformity. To solve this problem, a highspeed seed guide device with conical spiral airflow was designed, which can use highspeed positive pressure airflow to move seeds smoothly. To improve the uniformity of the airflow field in the device, a single-factor test was carried out to determine the reasonable range of each factor. Then, the four-factor and five-level central composite test was carried out. The four main factors were screw pitch, cone angle, width of gap, and angle of air-tube, and the evaluation index was the mean variance of airflow velocity. The test results showed that the optimal parameters of the high-speed seed guide device with conical spiral airflow were a screw pitch of 24.98 mm, cone angle of 7.47/55, width of gap of 5.31 mm, and angle of air-tube of 25.09°. The verification test showed that the relative error between the verification test value and the predicted value was less than 5%, indicating that the model had high reliability. This research can provide references for the research of highspeed seed guide technology and the innovative design of seed guide devices.