Prospective study of the factors associated with poor tolerance to ambulatory colonoscopy under conscious sedation

Grilo-Bensusan, Israel; Martín, Pablo Herrera; Jiménez-Mesa, Remedios; Álvarez, Valle Aguado

doi:10.17235/reed.2018.5287/2017

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…[ 10 ] The impact of analgesia-based sedation on the tolerance of patients undergoing colonoscopy has been assessed in several studies. [ 11 12 ] However, no randomized controlled study has yet, to our knowledge, been performed to assess the effect of the currently most often used analgesic agent on patient tolerance and pain and on cardiorespiratory parameters. This study evaluated the comparative efficacy and safety of ketamine over fentanyl in combination with propofol for the colonoscopy procedure.…”

Section: Introductionmentioning

confidence: 99%

Ketamine as the main analgesic agent during analgesia-based sedation for elective colonoscopy – A randomised, double-blind, control study

Kovačević¹,

Rizvanović²,

Adilović³

et al. 2022

Saudi J Anaesth

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Aim: The aim of the study was to compare the analgesic effects of ketamine over fentanyl combined with propofol in analgesia-based elective colonoscopy with purpose of patient safety and satisfaction. Methods: This is a double-blinded prospective randomized controlled trial. Ninety patients were included and randomized to either fentanyl-propofol (Group FP, n : 30), ketamine-propofol (Group KP, n : 30) or propofol-control group (Group C, n : 30). Group FP patients received fentanyl and propofol, Group KP received ketamine and propofol and Group C, propofol. In all groups, incremental doses of propofol were used to maintain a Ramsay sedation score (RSS) of 5. Respiratory depression and hemodynamic parameters were monitored for the first minute and every 5 min during endoscopy. Fifteen minutes after the procedure, the degree of pain was assessed using a visual analog scale (VAS), the quality of recovery according to the Aldrete score (ARS), complications during and after the procedure and additional doses of propofol were recorded. Results: Mean arterial pressure (MAP) at 5 and 30 min ( p < 0.05), heart rate (HR) at 15, 25 and 30 min ( p < 0.05) and peripheral oxygen saturation (SpO 2 ) at 30 min ( p < 0.05) were statistically significant for Group FP. Desaturation (* p = 0.033), and weakness (* p = 0.004) was also significant for Group FP at 20, 25 and 30 min ( p < 0.05). Pain was lower assessed for the Group KP according to the VAS (** p = 0.025). Conclusion: In analgesia-based colonoscopy, ketamine provides appropriate analgesia and less incidence of complications compared to fentanyl.

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Section: Introductionmentioning

confidence: 99%