Prospective Study of the Evaluation of the Usefulness of Tumor Typing by Narrow Band Imaging for the Differential Diagnosis of Gastric Adenoma and Well-Differentiated Adenocarcinoma

Nonaka, Kouichi; Arai, Satoru; Ban, Shinichi; Kitada, Hideki; Namoto, Masaaki; Nagata, Koji; Ochiai, Yasutoshi; Togawa, Osamu; Nakazato, Masamitsu; Nishimura, Makoto; Ishikawa, Kinya; Sasaki, Yutaka; Kita, Hiroto

doi:10.1111/j.1443-1661.2010.01070.x

Cited by 31 publications

(32 citation statements)

References 7 publications

(12 reference statements)

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“…Both gastric adenoma and well-differentiated carcinoma can be differentiated by NBI [21]. Nonaka et al showed accurate preoperative diagnosis of gastric tumors as adenoma and well-differentiated adenocarcinoma by NBI in 79 and 93 %, respectively.…”

Section: Surg Endoscmentioning

confidence: 97%

Risk factors for under-diagnosis of gastric intraepithelial neoplasia and early gastric carcinoma in endoscopic forceps biopsy in comparison with endoscopic submucosal dissection in Chinese patients

Zhang

et al. 2015

Surg Endosc

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Differences in pathologic diagnosis between endoscopic forceps biopsy (EFB) and endoscopic submucosal dissection (ESD) for gastric intraepithelial neoplasia (GIN) and early gastric carcinoma (EGC) in Chinese patients remain unknown. The aim of the study was to investigate risk factors for under-diagnosed pathology in initial EFB, compared to final ESD. We reviewed endoscopic and histopathologic findings for tumor location, size, macroscopic pattern, nodularity, erythema, erosion, GIN (low and high grade), and EGC diagnosed with the WHO criteria. Differences in those features between EFB and ESD were compared and risk factors for under-diagnosis by EFB were analyzed. Although concordant in most (74.9 %) cases between EFBs and ESDs, pathological diagnoses in 57 (25.1 %) cases were upgraded in ESDs. Compared to the concordant group, the lesion size ≥2 cm, and depressed and excavated patterns were significantly more frequent in the upgraded group. Further multivariate regression analysis demonstrated the depressed pattern and lesion size ≥2 cm as independent risk factors for upgraded pathology with the odds ratio of 5.778 (95 % confidence interval 2.893-11.542) and 2.535 (95 % confidence interval 1.257-5.111), respectively. Lesion size ≥2.0 cm and the depressed pattern at initial EFB were independent risk factors for pathologic upgrade to advanced diseases in ESD. Therefore, these endoscopic characteristics should be considered together with the initial EFB diagnosis to guide the optimal clinical management of patients with GIN and EGC.

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Section: Surg Endoscmentioning

confidence: 97%

Risk factors for under-diagnosis of gastric intraepithelial neoplasia and early gastric carcinoma in endoscopic forceps biopsy in comparison with endoscopic submucosal dissection in Chinese patients

Zhang

et al. 2015

Surg Endosc

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“…We performed NBI-combined magnifying endoscopy on protruding lesions in which differentiation between gastric adenoma and differentiated adenocarcinoma was necessary, and reported that the two lesions could be simply and accurately differentiated by classifying them into 4 types, as shown in Figure 10. According to our classification, 79% of type Ⅰ/Ⅱ patients had gastric adenoma, and 93% of type Ⅲ/Ⅳ patients had differentiated adenocarcinoma [23] . Gastric adenoma is a benign tumor, and the selection of course observation is not problematic in most cases.…”

mentioning

confidence: 81%

“…WOS appears in the presence of gastric adenoma or cancer, in most cases. In particular, its appearance is more frequent in patients with gastric adenoma and previous studies suggested its usefulness for the diagnosis of this condition [9,23] . WOS is visualized on white light or NBIcombined magnifying observation.…”

Section: Stomachmentioning

confidence: 94%

Role of narrow band imaging in endoscopic submucosal dissection

Nonaka

Nishimura²,

Kita³

2012

WJGE

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Narrow band imaging (NBI) is a new image enhancement system employing optic digital methods to enhance images of blood vessels on mucosal surfaces, allowing improved visualization of mucosal surface structures. Studies have progressed over the last several years, and the clinical usefulness has been demonstrated. NBI has become frequently applied for preoperative diagnosis before endoscopic submucosal dissection (ESD) of digestive tract cancers, as well as for assessment of the range of ESD for en-bloc resection of large lesions. Consensus has been reached with regard to the usefulness of NBI for detecting micro-lesions of esophageal squamous cell carcinoma indicated for ESD, for the diagnosis of the range and depth. NBI has also been attracting attention for diagnosing gastric cancer based on the observation of micro blood vessels on the mucosal surface and mucosal surface microstructures. The usefulness of NBI has been reported in relation to various aspects of colon cancer, including diagnoses of the presence, quality, range, and depth of lesions. However, as NBI has not surpassed diagnostic methods based on magnifying observation combined with the established and widely employed dye method, its role in ESD is limited at present. Although NBI is very useful for the diagnosis of digestive tract cancers, comprehensive endoscopic diagnosis employing the combination of conventional endoscopy including dye spraying, EUS, and NBI may be important and essential for ESD.

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“…Regular, round, slit or villous like pits indicate non-neoplastic lesions [34][35][36] . These changes are however not always straightforward as findings can be altered by many conditions such as chronic inflammation, ulceration, atrophy or metaplasia and H. pylori infection [37][38][39] . Superficial but elevated lesions make the visibility of micro-vascular pattern difficult [35,40,41] .…”

Section: Superficial Gastric Cancermentioning

confidence: 99%

Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract

Singh

Hussain

Loong

2013

WJGE

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Endoscopy plays an important role in the diagnosis and management of gastrointestinal (GI) tract disorders. Chromoendoscopy has proven to be superior to white light endoscopy for early detection of various GI lesions. This has however been fraught with problems. The use of color stains, time taken to achieve an effect and the learning curve associated with the technique has been some of the pitfalls. Narrow band imaging (NBI) particularly in combination with magnifying endoscopy may allow the endoscopist to accomplish a fairly accurate diagnosis with good histological correlation similar to results achieved with chromoendoscopy. Such enhanced detection of pre-malignant and early neoplastic lesions in the gastrointestinal tract should allow better targeting of biopsies and could ultimately prove to be cost effective. Various studies have been done demonstrating the utility of this novel technology. This article will review the impact of NBI in the diagnosis of upper gastrointestinal tract disorders.

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Prospective Study of the Evaluation of the Usefulness of Tumor Typing by Narrow Band Imaging for the Differential Diagnosis of Gastric Adenoma and Well-Differentiated Adenocarcinoma

Abstract: The tumor typing based on NBI was useful for the endoscopic differentiation of gastric adenoma and well-differentiated adenocarcinoma.

Cited by 31 publications

References 7 publications

Risk factors for under-diagnosis of gastric intraepithelial neoplasia and early gastric carcinoma in endoscopic forceps biopsy in comparison with endoscopic submucosal dissection in Chinese patients

Risk factors for under-diagnosis of gastric intraepithelial neoplasia and early gastric carcinoma in endoscopic forceps biopsy in comparison with endoscopic submucosal dissection in Chinese patients

Role of narrow band imaging in endoscopic submucosal dissection

Narrow band imaging with magnification for the diagnosis of lesions in the upper gastrointestinal tract

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