Prospective Study of Serum Adiponectin and Incident Metabolic Syndrome

Abstract

OBJECTIVEIncreased adiponectin levels may play a protective role in the development of metabolic abnormalities, but prospective studies of the predictive value of serum adiponectin to identify individuals at high risk of new-onset metabolic syndrome are lacking. We investigated whether serum adiponectin predicts incident cases of the metabolic syndrome in a population-based longitudinal study.RESEARCH DESIGN AND METHODSA prospective cohort study was conducted of 2,044 adults (831 men and 1,213 women) aged 40–70 years without metabolic syndrome examined in 2005–2008 (baseline) and 2008–2011 (follow-up). Baseline serum adiponectin concentrations were measured by radioimmunoassay.RESULTSDuring an average of 2.6 years of follow-up, 153 men (18.4%) and 199 women (16.4%) developed metabolic syndrome. In multivariable-adjusted models, the odds ratio for incident metabolic syndrome comparing the highest with the lowest quartiles of adiponectin levels was 0.25 (95% CI 0.14–0.47) in men and 0.45 (0.28–0.74) in women. While serum adiponectin did not improve the area under the ROC curve for predicting new-onset metabolic syndrome based on information from metabolic syndrome components, the net reclassification improvement and the integrated discrimination improvement of prediction models including adiponectin were significantly higher compared with those of models not including adiponectin among men, with a significant difference between men and women (P = 0.001).CONCLUSIONSIncreased adiponectin is an independent protective factor for incident metabolic syndrome in men and women, and it may have a clinical role in predicting new-onset metabolic syndrome among men.

The association between carbon and nitrogen stable isotope ratios of human hair and metabolic syndrome

“…We conducted an ancillary study of cross-sectional design within the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population (KoGES-ARIRANG), an ongoing, community-based cohort study [13]. KoGES-ARIRANG includes 5178 men and women, aged 40 to 70 y at baseline (2005)(2006)(2007)(2008), of whom 3862 (74.6%) attended the first follow-up survey (April 2008-January 2011).…”

“…Comprehensive questionnaires were used to collect information, including medical and family history, health behavior, dietary intake, and physical examinations, which were performed according to standard procedures [13,16]. Body weight and height were measured while participants were wearing light indoor clothing without shoes.…”

“…Biomarkers could be useful to identify and predict the risk for chronic diseases such as metabolic syndrome, diabetes mellitus, and cardiovascular disease [13][14][15]. Given the high prevalence of metabolic syndrome and its potential consequences, little is known about the ability of δ 13 C and δ 15 N to serve as biomarkers of metabolic syndrome.…”

Role of Adipose Tissue in Metabolic System Disorders

“…In this regard, leptin and adiponectine are important because these adipokines are directly correlated to the size and mass of LDs [85][86][87]. There is also a significant negative relationship between CRP levels (WHERE?)…”

Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Aidpocytes : Role of extracelluar signal kinase 1/2 (ERK1/2) and farkhead box protein 01 (FOX01)

“…These adipocyte derived factors play an important role in tissue cross-talk and maintenance of whole-body metabolic homeostasis. Adiponectin has gained the attention since it is an insulin sensitizing hormone and circulating adiponectin levels appears to be one of the strongest predictors of metabolic syndrome that includes insulin resistance, T2D, cardiovascular events, and hypertension (239)(240)(241). FOXO1 has been reported to form a complex with C/EBPα at the mouse adiponectin promoter to enhance adiponectin gene expression (242).…”