Prospective study of risk factors for early and persistent wheezing in childhood

Lewis, Sarah; Richards, David F.; Bynner, John; Butler, N. R.; Britton, John

doi:10.1183/09031936.95.08030349

Cited by 185 publications

(149 citation statements)

References 41 publications

(63 reference statements)

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“…The characteristics of the sample as a whole (n = 897) and of the children that never presented 5 variables. Despite the greater prevalence of all of the wheezing patterns in males, there was statistically significant difference only for the persistent pattern (p = 0.04).…”

Section: Resultsmentioning

confidence: 99%

“…(1) However, in this article, we will analyze the phenotypes initially proposed by one author, (2) despite the fact that other phenotypes have been proposed. (3)(4)(5)(6)(7) The importance of wheezing patterns is based on the fact that their determining factors and, principally, prognostic factors, are distinct, which can have various therapeutic implications. (8,9) Wheezing is one of the symptoms typically present in asthma, although it is known that not all wheezing is synonymous with this disease.…”

Section: Introductionmentioning

confidence: 99%

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Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS) Brasil, 1993-2004

et al. 2008

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Objective: To study the prevalence of wheezing patterns and their associations with independent variables. Methods: Cohort study of live births in 1993 in Pelotas, Brazil. A systematic subsample (20%) of the original cohort was evaluated at 6 months, 12 months and 4 years. At 10-12 years, 87.5% of the original cohort was contacted. Wheezing was categorized: transient, wheezing at 4 years but not at 10-12; persistent, wheezing at all evaluations; late-onset, wheezing at 10-12 years. Independent variables were analyzed: gender; skin color; family income; smoking/asthma during pregnancy; breastfeeding; respiratory infection/diarrhea (during the 1st year); family members with asthma/ allergy (at 4 years and at 10-12); physician-diagnosed rhinitis/eczema (at 10-12 years). Results: The subsample comprised 897 adolescents. Wheezing patterns were expressed as prevalence (95% CI): transient, 43.9% (40.7-47.2); persistent, 6.4% (4.8-8.0); and late-onset, 3.3% (2.2-4.5). The transient pattern was more common in children from low-income families, children breastfed for less time, children with a history of respiratory infections (during the 1st year) and children with asthma in the family (at 4 years). The persistent pattern was almost twice as common in males, in children whose mothers had asthma during pregnancy, in children with respiratory infections (during the 1st year) and in children with asthma in the family (at 4 and 10-12 years). The late-onset pattern was more prevalent among those with asthma in the family (at 10-12 years) and those diagnosed with rhinitis (at 10-12 years), being less prevalent among those reporting respiratory infections (during the 1st year) and those diagnosed with eczema (at 10-12 years). Conclusions: Knowledge of the associations of wheezing patterns allows us to adopt preventive and therapeutic measures.Keywords: Respiratory sounds; Asthma; Epidemiology; Hypersensitivity. ResumoObjetivo: Estudar a prevalência dos padrões de sibilância respiratória e suas associações com variáveis independentes. Métodos: Coorte de nascidos vivos, 1993, Pelotas (RS); subamostra sistemática de 20% da coorte original acompanhada aos 6 e 12 meses e 4 anos; aos 10-12 anos localizou-se 87,5% da coorte original. Definição dos padrões: transitório: chiado até 4 anos e ausência de chiado aos 10-12 anos; persistente: chiado em todos acompanhamentos; início tardio: chiado aos 10-12 anos. Variáveis independentes: gênero; cor da pele; renda familiar; fumo/asma na gravidez; amamentação; infecção respiratória/diarréia (1º ano); alergia e asma na família (4 e 10-12 anos); diagnóstico médico de rinite/eczema (10-12 anos). Resultados: O total da subamostra foi de 897 adolescentes. Prevalência (IC95%) dos padrões de sibilância: transitório 43,9% (40,7-47,2);persistente 6,4% (4,8-8,0); de início tardio 3,3% (2,2-4,5). O transitório foi mais freqüente em crianças de famílias de baixa renda, com menor duração da amamentação, relato de infecções respiratórias (1º ano) e história familiar de asma (4 anos); o persistente f...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS) Brasil, 1993-2004

et al. 2008

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“…Previous studies have shown that low birth weight can be a risk factor for asthma in children and adults. 14,15 We assume that the low birth weight is related to small airways, which in turn increases the susceptibility to asthma. An important finding was that birth weight was unrelated to atopy.…”

Section: Discussionmentioning

confidence: 99%

“…Such risk factors include parental, particularly maternal, smoking 10 -14 and dampness at home. 6,10,11 Low birth weight 14,15 and breastfeeding of infants for less than a few months 16 have also been identified as risk factors for asthma. The risk factors for incident cases in longitudinal studies have been poorly studied.…”

mentioning

confidence: 99%

Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

et al. 2001

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ABSTRACT.Objective. An increasing prevalence of asthma has been reported worldwide as well as in Sweden. In 1996, the prevalence of asthma and type 1 allergy was investigated in a cohort of 3525 children 7 and 8 years old in 3 areas of northern Sweden. The aim of the present study was to estimate the incidence of asthma and to identify risk factors for incident cases over 1 year.Methods. The study started with a parental questionnaire, the International Study of Asthma and Allergies in Childhood questionnaire with additional questions, a skin prick test, and a validation study. The cohort was followed up after 1 year with the same questions. The response rate to the questionnaire was 97% in 1996, and 3339 children (97%) participated both in 1996 and 1997.Results. The incidence of physician-diagnosed asthma was 0.9/100/year; of wheezing, 3.8/100/year; and of new frequent or daily users of asthma medicines, 1.1/100/year. There was no difference by sex. The risk factor pattern based on incident cases of asthma was different from that based on prevalent cases. Significant risk factors for incident asthma were a positive skin test (odds ratio [OR]: 9.3; 95% confidence interval [CI]: 3.8 -22.7); low birth weight (OR: 7.4; 95% CI: 2.2-24.5); and family history of asthma (OR: 2.6; 95% CI: 1.1-6.3). Having or having had pets at home was associated with a decreased risk for asthma and wheezing based on prevalent cases, although it was associated with an increased risk for incidence of wheezing (OR: 2.9; 95% CI: 1.3-6.2). Remission of asthma, which was reported by 10% of the children with current asthma during 1 year, was associated with a negative skin test.Conclusion. The incidence of asthma at the age of 8 years was high, but remission was also common. Important risk factors for the development of asthma at this age were type 1 allergy, low birth weight, and family history of asthma. Furthermore, the results suggest that in a region where sensitivity to domestic animals is a strong risk factor for asthma, the presence of pets in the home may have different effects in early childhood compared with later in childhood. Pediatrics 2001;107(3). URL: http://www.pediatrics.org/cgi/content/full/107/3/e37; asthma, incidence, remission, risk factors, children.

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“…Most of these studies were based on questionnaires not validated in preterms with a lack of a universal definition for wheeze and asthma. However, low birth weight per se may predispose to an increased risk of wheeze and lower lung function which may increase the likelihood of a wheezing response to viral infections in early childhood (Greenough et al, 2005;Lewis et al, 1995). Other risk factors for wheeze and asthma in later life in preterm children include male sex (Palta et al, 2001) and African-American ethnicity (Kumar et al, 2008).…”

Section: Childhoodmentioning

confidence: 99%

Preterm Birth and Long-Term Pulmonary Function

Narang¹,

Al-Naimi²

2012

Preterm Birth - Mother and Child

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Prospective study of risk factors for early and persistent wheezing in childhood

Cited by 185 publications

References 41 publications

Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS) Brasil, 1993-2004

Padrões de sibilância respiratória do nascimento até o início da adolescência: coorte de Pelotas (RS) Brasil, 1993-2004

Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

Preterm Birth and Long-Term Pulmonary Function

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