Prospective study of lung function and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study

Kubota, Yasuhiko; Folsom, Aaron R.; Matsushita, Kunihiro; Couper, David J.; Tang, Weihong

doi:10.1016/j.atherosclerosis.2017.10.013

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…Active smoking was the only parameter associated with a significant increase in growth rate, and double the rate of thoraco-abdominal aneurysm expansion [9]. In Marfan syndrome [10], subjects are highly predisposed to thoracic aortic aneurysm and/or Type A dissection, with virtually every patient developing aortic disease at some point during their lifetime [38]. In addition, giant bullous and emphysema have been reported in Marfan patients [39].…”

Section: Discussionmentioning

confidence: 99%

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Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study

Fujikura

Albini

Barr

et al. 2021

International Journal of Cardiology

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Background: The prevalence of abdominal aortic aneurysm is high in chronic obstructive pulmonary disease (COPD) population. Emphysema involves proteolytic destruction of elastic fibers. Therefore, emphysema may also contribute to thoracic aorta dilatation. This study assessed aorta dilation in smokers stratified by presence of COPD, emphysema and airway thickening. Methods: Aorta diameters were measured on 3D magnetic resonance angiography in smokers recruited from the Multi-Ethnic Study of Atherosclerosis (MESA), the Emphysema and Cancer Action Project (EMCAP), and the local community. COPD was defined by standard spirometric criteria; emphysema was measured quantitatively on computed tomography and bronchitis was determined from medical history. Results: Participants (n = 315, age 58-79) included 150 with COPD and 165 without COPD, of whom 56% and 19%, respectively, had emphysema. Subjects in the most severe quartile of emphysematous change showed the largest diameter at all four aorta locations compared to those in the least severe quartiles (all p < 0.001). Comparing subjects with and without COPD, aorta diameters were larger in participants with severe COPD in ascending and arch (both p < 0.001), and abdominal aorta (p = 0.001). Chronic bronchitis and bronchial wall thickness did not correlate with aorta diameter. In subjects with emphysema, subjects with coexistence of COPD showed larger aorta than those without COPD in ascending (p = 0.003), arch (p = 0.002), and abdominal aorta (p = 0.04). Conclusions: This study showed larger aorta diameter in subjects with COPD and severe emphysema compared to COPD related to chronic bronchitis or bronchial wall thickening.

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Section: Discussionmentioning

confidence: 99%

“…Other known risk factors include increased pressure [8], i.e. hypertension or bicuspid aortic valve jets [1] and diseases that weaken the aortic wall including atherosclerosis [8], Marfan's and other connective tissue diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study

Fujikura

Albini

Barr

et al. 2021

International Journal of Cardiology

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“…18 In a recent prospective population-based cohort study, during the 284 969 person-years of follow-up, obstructive spirometric patterns were associated with increased risk of AAA independent of smoking, suggesting that COPD may increase the risk of AAA. 19 A recent meta-analysis found that COPD is not associated with AAA growth, even though COPD is independently and positively associated with the presence of AAA. 20 The protective role of diabetes mellitus against AAA was not confirmed in our study similarly to the Liège screening programme, 21 probably due to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

Risk Factor Assessment in a Greek Cohort of Patients With Large Abdominal Aortic Aneurysms

et al. 2018

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Environmental and genetic risk factors contribute to the etiology of abdominal aortic aneurysms (AAAs). Matrix metalloproteinases (MMPs) have been associated with the pathophysiology of AAAs. A prospective, nonrandomized case-control study was undertaken to investigate the risk factors for large AAAs (≥5.5 cm) among 175 male Greek AAA patients and to compare the results with a cohort of 166 male controls free from any aortic dilatation, as confirmed by ultrasonography from an existing AAA screening program in the same region. We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs. Multiple logistic regression analysis revealed AAA family history ( P = .028), hypercholesterolemia ( P < .001), and current smoking ( P < .001) as AAA risk factors. Statistical difference was reached in genotype ( P = .047) and allele ( P = .037) frequencies for rs2252070, but the results did not remain significant after correction for multiple testing. No significant differences in genotype or allele frequencies for rs3918242 were detected. In summary, AAA family history, hypercholesterolemia, and current smoking were found to be risk factors for large AAAs.

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“…From 1987 to 1989 until 2011, the Atherosclerosis Risk in Communities study followed 14 269 participants aged 45 to 64 years without a history of AAA surgery. 25 During 284 969 person-years of follow-up, 534 incident AAA events were documented. After adjustment for AAA risk factors including smoking status and pack-years of smoking, there was still an increased risk for the development of AAAs in patients with chronic obstructive pulmonary disease (COPD; HR = 1.66; 95% CI = 1.34-2.05; P < .05) and restrictive lung disease (HR = 1.45; 95% CI = 1.04-2.02; P < .05).…”

Section: Abdominal Aortic Aneurysms and Chronic Obstructive Pulmonarymentioning

confidence: 99%

“…After adjustment for AAA risk factors including smoking status and pack-years of smoking, there was still an increased risk for the development of AAAs in patients with chronic obstructive pulmonary disease (COPD; HR = 1.66; 95% CI = 1.34-2.05; P < .05) and restrictive lung disease (HR = 1.45; 95% CI = 1.04-2.02; P < .05). 25 Several studies have verified that patients with COPD have an increased prevalence of AAAs. 26 –29 Smoking is also a common risk factor for both AAAs and COPD.…”

Section: Abdominal Aortic Aneurysms and Chronic Obstructive Pulmonarymentioning

confidence: 99%

The Association Between Abdominal Aortic Aneurysms With Cardiovascular and Noncardiovascular Diseases

2018

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Prospective study of lung function and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study

Abstract: In the prospective population-based cohort study, obstructive and restrictive spirometric patterns were associated with increased risk of AAA independent of smoking, suggesting that COPD and RLD may increase the risk of AAA.

Cited by 11 publications

References 35 publications

Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study

Aortic enlargement in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD study

Risk Factor Assessment in a Greek Cohort of Patients With Large Abdominal Aortic Aneurysms

The Association Between Abdominal Aortic Aneurysms With Cardiovascular and Noncardiovascular Diseases

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