Prospective Study of Human Betaherpesviruses After Renal Transplantation

Kidd, IM; Clark, Duncan A.; Sabin, Caroline; Andrew, Dawn; Hassan‐Walker, Aycan F.; Sweny, P.; Griffiths, Paul; Emery, Vincent C.

doi:10.1097/00007890-200006150-00032

Cited by 126 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were similar to previous reports focusing on hematopoietic stem cell or solid organ transplant patients [22,28–31]. Chan et al [28] investigated bone marrow transplant recipients, and reported CMV in 61%, HHV-6 in 28% and HHV-7 in 53% of the individuals, while Kidd et al [29] researched renal transplant patients and observed parallel viruses in 58%, 23% and 46% of the patients. A high percentage of infected patients were also recorded by Wang et al [30], and this is in agreement with the observations presented here, especially with respect to CMV and EBV incidence.…”

Section: Discussionsupporting

confidence: 90%

“…Otherwise, it is well-known that CMV alone or in concomitant presence of other herpesviruses may initiate or exacerbate GvH disease [39], hence it is difficult to pinpoint the cause of such high aminotransferases level in our patients. The possible contribution of HHV-7 to the process of transplant rejection has already been indicated by other authors [29]. On the other hand, Chan et al [40] did not observe, in pediatric allogeneic recipients of HSCT, a significantly higher risk for development of acute GvHD in HHV-7-positive patients.…”

Section: Discussionmentioning

confidence: 82%

“…In most cases observations were carried out in the early post-transplant period, when immunosuppression is most intense, more often up to 12 weeks [28,29,33]. The present paper draws attention to the common appearance of infections not only in the period of hematologic reconstitution and the associated immunosuppression, but also in the late post-transplant period.…”

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Lymphotropic herpesvirus DNA detection in patients with active CMV infection – a possible role in the course of CMV infection after hematopoietic stem cell transplantation

et al. 2011

View full text Add to dashboard Cite

SummaryBackgroundThe natural history of cytomegalovirus (CMV) infection and disease in transplant recipients prompts researchers to look for other factors contributing to this infection. The ubiquity of lymphotropic herpesviruses (EBV, HHV-6, and HHV-7) and the possibility of their activation during immunosuppression may suggest their participation in progression of CMV infection in patients after hematopoietic stem cell transplantation (HSCT).Material/MethodsThe presence of CMV, EBV, HHV-6 and HHV-7 was confirmed through detection of viral DNA isolated from leukocytes. Allo-HSCT recipients (n=55) were examined repeatedly within the average period of 14±7.3 months post-transplant.ResultsCMV DNA was detected in 24% of samples, while EBV, HHV-6 and HHV-7 were detected in 20%, 15% and 14% of samples, respectively. Based on the presence of CMV infection at particular time-points (months) after transplantation, the recipients were divided into 3 groups: Group I (N=15) with persistent infection, Group II (N=20) with transient infection, and Group III (N=20) without CMV infection. In Group I, the mean CMV load was significantly higher than in Group II, and the clinical condition of Group I patients was poorer. All these patients manifested clinical symptoms, and all had episodes of GvHD. All Group I patients developed multiple infections; EBV in 80%, HHV-6 in 47% and HHV-7 in 87% of patients. In the remaining groups, with the exception of HHV-6 in group II, the frequency of infected patients was lower. In addition, CMV presence was often preceded by another herpesvirus.ConclusionsThe results suggest that other herpesviruses, mainly HHV-7, could predispose CMV to cause chronic infection.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Lymphotropic herpesvirus DNA detection in patients with active CMV infection – a possible role in the course of CMV infection after hematopoietic stem cell transplantation

et al. 2011

View full text Add to dashboard Cite

show abstract

“…These include CNS disease [53], myelosuppression [54], aGVHD [55], and allograft dysfunction and rejection [56]. Data from a number of studies suggest a potential indirect effect of HHV-7 to increase rates of CMV reactivation and disease in HCT [57] and SOT [58,59] recipients, but this is not a consistent finding [52]. Future studies of HHV-6B should incorporate testing for HHV-7 to advance our understanding of its possible significance in transplantation.…”

Section: Human Herpesvirusmentioning

confidence: 99%

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Hill

Zerr

2014

Current Opinion in Virology

View full text Add to dashboard Cite

Roseoloviruses frequently reactivate in transplant recipients. We review the impact of Roseoloviruses in transplant recipients and highlight research priorities. Human herpesvirus 6A (HHV-6A) and HHV-6B were recently classified as distinct species with important differences. Both viruses can result in inherited chromosomally integrated HHV-6, which may cause complications after transplant. HHV-6B is the primary species associated with disease and appears to have pleiotropic effects on the central nervous system. Small preemptive and prophylactic studies have not shown a statistically significant impact on HHV-6 disease. Although Roseoloviruses are associated with diverse complications in transplant patients, studies providing strong evidence for a causal role are lacking. Trials focusing on prevention and treatment will be important to inform the significance of Roseolovirus reactivation.

show abstract

“…Patients with CMV disease were more likely to have HHV-7 DNA detection than those with asymptomatic CMV infection (31% vs 0%, P = 0.13) [38]. In a study in renal transplant recipients, patients with CMV and HHV-7 coinfection were more likely to have CMV disease compared with those with CMV infection only [39]. In liver transplant recipients, however, no pathogenic effect of HHV-7 was documented [40].…”

Section: Human Herpesvirus-7mentioning

confidence: 95%

Recent advances in the management of infections in liver transplant recipients

Singh¹

2001

Curr Infect Dis Rep

View full text Add to dashboard Cite

Antimicrobial-resistant bacteria (vancomycin-resistant enterococci and Staphylococcus aureus) have emerged as leading pathogens in liver transplant recipients. Liver transplant recipients have also been shown to be uniquely more susceptible to harboring extended-spectrum beta-lactamase-producing Enterobacteriaceae. The frequency of mycelial fungal infections has increased; however, effective prophylaxis and management of these infections remains suboptimal. Emerging reports have highlighted the morbidity due to novel herpesviruses in these patients. Finally, the emergence of ganciclovir resistance in cytomegalovirus has implications relevant for all solid organ transplant recipients.

show abstract

Prospective Study of Human Betaherpesviruses After Renal Transplantation

Abstract: HHV-7 should be further investigated as a possible co-factor in the development of CMV disease in renal transplant patients and may potentially exacerbate graft rejection. No clear pathological role was observed for HHV-6.

Cited by 126 publications

References 29 publications

Lymphotropic herpesvirus DNA detection in patients with active CMV infection – a possible role in the course of CMV infection after hematopoietic stem cell transplantation

Lymphotropic herpesvirus DNA detection in patients with active CMV infection – a possible role in the course of CMV infection after hematopoietic stem cell transplantation

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Recent advances in the management of infections in liver transplant recipients

Contact Info

Product

Resources

About