Prospective Study of Functional Status and Quality of Life Before and After Lung Transplantation

Lanuza, Dorothy M.; Lefaiver, Cheryl; Cabe, Mary Mc; Farcas, Gabriella A.; Garrity, Edward R.

doi:10.1378/chest.118.1.115

Cited by 118 publications

(87 citation statements)

References 19 publications

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“…To patients, quality of life (QOL) can be as important as quantity of life, and lung transplantation can almost be considered a type of treatment in which, in some instances, quality of life is improved even if little or no gain in quantity of life occurs. Multiple longitudinal studies have recently shown improvements in QOL following lung transplantation, some as early as 3 mo posttransplant (Gross et al 1995;Cohen et al 1998;Lanuza et al 2000). More than 90% of lung transplant survivors are satisfied with their decision to undergo transplantation.…”

Section: Chronic Lung Allograft Dysfunctionmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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Since the first successful lung transplant 30 years ago, lung transplantation has rapidly become an established standard of care to treat end-stage lung disease in selected patients. Advances in lung preservation, surgical technique, and immunosuppression regimens have resulted in the routine performance of lung transplantation around the world for an increasing number of patients, with wider indications. Despite this, donor shortages and chronic lung allograft dysfunction continue to prevent lung transplantation from reaching its full potential. With research into the underlying mechanisms of acute and chronic lung graft dysfunction and advances in personalized diagnostic and therapeutic approaches to both the donor lung and the lung transplant recipient, there is increasing confidence that we will improve short-and long-term outcomes in the near future.

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Section: Chronic Lung Allograft Dysfunctionmentioning

confidence: 99%

Overview of Clinical Lung Transplantation

Yeung

Keshavjee

2014

Cold Spring Harbor Perspectives in Medicine

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“…Several studies have been performed with health‐outcome measurement instruments that capture a specific element of HRQoL. In the short term, most patients are found to experience meaningful improvements after lung transplantation 5, 6, 7, 8, 9, 10. However, the generalizability of these studies is constrained by methodological problems such as cross‐sectional design, short‐term follow‐up, and small sample sizes.…”

Section: Introductionmentioning

confidence: 99%

Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Parizi

Krabbe

Verschuuren

et al. 2018

American Journal of Transplantation

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During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health‐related quality of life (HRQoL) in patients with various end‐stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long‐term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow‐up, 370 post‐LTx patients were evaluated annually for up to 15 years. For all wait‐listed and follow‐up patients, the following four HRQoL instruments were administered: State‐Trait Anxiety Inventory, Zung Self‐rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross‐sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow‐up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long‐term follow‐up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.

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“…34,35 HRQOL has been reported by several investigators to improve significantly within the first few years after LTx. 35,36 Beyond two years after LTx-the frame in which any major clinical complications to occur may begin to develop and threaten the patients recovered autonomy-HRQOL declines again. Furthermore, many investigators have shown that exercise capacity continues to be impaired after LTx despite the removal of limitations.…”

Section: Qol In Patients With Lung Transplantation (Ltx)mentioning

confidence: 99%