Prospective study of diabetes mellitus and liver cancer in Japan

Fujino, Yoshihisa; Mizoue, Tetsuya; Tokui, Noritaka; Yoshimura, Takesumi

doi:10.1002/dmrr.214

Cited by 72 publications

(70 citation statements)

References 34 publications

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“…The association between DM and HCC was found to be modified by hepatitis virus infection, heavy alcohol consumption, and other known risk factors. 51,[61][62][63] Fujino et al 2001 61 found that the relative risk (RR) of DM for primary liver cancers was 2.06 (95% CI, 1.01-4.19) after adjustment for smoking, alcohol, and diseases associated with liver cancer in a prospective study of diabetes and liver cancers in Japan. Diabetes increased the risk of liver cancers in patients with hepatitis and/or cirrhosis and it was concluded and confirmed by a few subsequent reported studies, although the modified factors were different in different studies.…”

Section: Impact Of Diabetes As Risk Factor In Hepatocellular Carcinomamentioning

confidence: 99%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma (HCC) is an important cause of death all over the world, more so in Asia and Africa. The representative data on epidemiology of HCC in India is very scanty and cancer is not a reportable disease in India and the cancer registries in India are mostly urban. 45 million people who are suffering from chronic Hepatitis B virus (HBV) infection and approximately 15 million people who are afflicted with chronic Hepatitis C virus (HCV) infection in India. HBV and HCV infection is considered an important etiologic factor in HCC. Positive association between HCC and consumption of alcohol where alcohol contribute as a cofactor for hepatotoxins and hepatitis viruses. Aflatoxin contamination in the diets, Hepatitis B virus infection and liver cirrhosis in Andhra Pradesh, India and direct chronic exposure to aflatoxins was shown to cause liver cirrhosis. Cirrhosis of liver of any cause lead to develop about 70%-90% of HCC. Aflatoxin interact synergistically with Hepatitis B virus (HBV)/Hepatitis C virus (HCV) infection which increase the risk of HCC. HBV infection, HBV infection with Aflatoxin exposure, viral infection and alcohol consumption leading to overt cirrhosis of the liver, alcohol consumption leading to cirrhosis of the liver with viral infection are the predominant risk factor for the development of HCC. HCV and alcohol are also associated with HCC in India. Indians develop diabetes at younger age, Asians have strong genetic susceptibility for type II diabetes. Diabetes mellitus is identified as a risk factor for HCC. Prevention of viral infection by universal vaccination against hepatitis virus, HCC surveillance program, preventing alcoholic liver diseases, fungal contamination of grains and ground crops to prevent basically Aflatoxin exposure are important measures to prevent liver diseases and HCC among those at risk. ( J CLIN EXP HEPATOL 2014;4:S34-S42)

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Section: Impact Of Diabetes As Risk Factor In Hepatocellular Carcinomamentioning

confidence: 99%

Risk Factors for Hepatocellular Carcinoma in India

Kar

2014

Journal of Clinical and Experimental Hepatology

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“…13 The followup has been described in detail elsewhere. 14,15 Briefly, the baseline survey was conducted from 1986 to 1989. We invited all inhabitants aged from 30 to 79 years living in A town, B village, and selected districts of C city and D town (15,417 subjects in total) to participate in a self-administrated questionnaire survey.…”

Section: Study Populationmentioning

confidence: 99%

Prospective study of vegetable consumption and liver cancer in Japan

Pham¹,

Fujino²,

Ide³

et al. 2006

Intl Journal of Cancer

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We examined the relationship between vegetable consumption and the risk of death from liver cancer in a cohort study in Japan. This analysis is based on data from 6,049 subjects aged 40 to 79 years enrolled in a cohort study conducted in Fukuoka Prefecture, Japan. The follow-up period was from 1986 to 1999. All liver cancer deaths were recorded. The vegetable consumption was classified into 3 groups: ''once per week or less,'' ''2-4 times per week'' and ''daily intake.'' The Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence interval (95% CI). A total of 51 male and 22 female liver cancer deaths were recorded during 62,343 person-years of follow-up. The ''once per week or less'' group was considered the referent group. In males, the multivariate HRs of liver cancer deaths were 0.61 (95% CI: 0.33-1.14) and 0.25 (95% CI: 0.11-0.59) in the ''2-4 times per week'' and ''daily intake'' groups, respectively. In females, the multivariate HRs were 0.44 (95% CI: 0.13-1.51) and 0.51 (95% CI: 0.16-1.69), respectively. The multivariate HRs were also reported by history of hepatitis and cirrhosis. In those without a history of these conditions, the multivariate HRs were 0.54 (95% CI: 0.27-1.09) and 0.36 (95% CI: 0.16-0.83). In those with a history of these conditions, the multivariate HRs were 0.58 (95% CI: 0.22-1.56) and 0.37 (95% CI: 0.13-1.06), respectively. Our study reveals an inverse association between vegetable consumption and the risk of death from liver cancer. These results provide further evidence of the protective effect of vegetables against liver cancer. ' 2006 Wiley-Liss, Inc.Key words: liver cancer; mortality; vegetable; cohort study Liver cancer is one of the malignancies for which the major etiologic factors have been well established. Among these, chronic infection with either hepatitis B virus (HBV) or hepatitis C virus (HCV) has been well documented as a major cause. 1-3 Infection either with HBV or HCV increases the risk of this cancer more than 10-fold. 4 Many other possible etiologic factors, including exposure to excessive alcohol consumption, dietary aflatoxin, diabetes mellitus, cirrhosis of any etiology and others, have been shown to play a role in the development of this cancer. 1,5 A large number of epidemiological studies have been conducted to examine the relationship of high intake of vegetables with a wide range of cancers. 6,7 In 1997, an international review panel (World Cancer Research Fund) 8 reviewed the results of published studies and reported that diets high in vegetables were considered to decrease the risk of most cancer sites. With regard to liver cancer, however, we have identified only a few studies, which examined the association between vegetable consumption and liver cancer, and the results of these were inconsistent. 9-12 To contribute to clarifying this relationship, we conducted this study to investigate the association between vegetable consumption and liver cancer mortality, based on a population-based prospective cohort study in...

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“…Our cohort study was started in Fukuoka Prefecture in 1986 -89, and the follow-up method has been described elsewhere (Fujino et al, 2001;Mizoue et al, 2000;Utoguchi et al, 1997). The number of subjects who were invited to participate and fill in a self-administered questionnaire was 15 417.…”

Section: Study Populationmentioning

confidence: 99%

Dietary factors and stomach cancer mortality

et al. 2002

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The present study examined the relationship between stomach cancer and the low intake of fresh fruit and vegetables and/or a high intake of pickled, preserved or salted foods and frequent use of cooking oil. During 139 390 person -year of follow-up of over 13 000 subjects, 116 died from stomach cancer. Using a Cox proportional hazards -regression analysis of relative risk (RR, 95% CI) controlling for age, sex, smoking and other dietary factors, a significant decline was found with a high consumption of green and yellow vegetables (RR=0.4, 95% CI=0.2 -0.9). Reductions of between 40 and 50% were also observed with a high consumption of fresh foods (fruit, cuttle fish, tofu, and potatoes), but these associations were not statistically significant. The risk was significantly increased by the high consumption of processed meat (RR=2.7, 95% CI=1.0-7.4) and by the frequent use of cooking oil (RR=4.0, 95% CI=1.3-11.8). The high consumption of pickled food and traditional soups also increased risk, but not significantly. The findings suggest that a diet high in salt and low in vitamins may be associated with an increase in stomach cancer.

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Prospective study of diabetes mellitus and liver cancer in Japan

Abstract: A significant association between diabetes and liver cancer was observed. Moreover, this association was modified by hepatitis and cirrhosis.

Cited by 72 publications

References 34 publications

Risk Factors for Hepatocellular Carcinoma in India

Risk Factors for Hepatocellular Carcinoma in India

Prospective study of vegetable consumption and liver cancer in Japan

Dietary factors and stomach cancer mortality

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