Prospective study of correlations between biopsy-detected high grade prostatic intraepithelial neoplasia, serum prostate specific antigen concentration, and race

Fowler, Jackson E.; Bigler, Steven A.; Lynch, Cynthia A.; Wilson, Shandra; Farabaugh, Paul B.

doi:10.1002/1097-0142(20010401)91:7<1291::aid-cncr1131>3.0.co;2-j

Cited by 34 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bostwick et al [11] showed that HGPIN is a frequent finding in needle biopsies and is present in 9.5-16.5% of cases. In the study by Fowler et al [12] the prevalence of HGPIN in sextant biopsies in black and white men was 13.4% and 5.9%, respectively ( P < 0.001).…”

Section: Discussionmentioning

confidence: 66%

Predictors of prostate cancer on extended biopsy in patients with high‐grade prostatic intraepithelial neoplasia: a multivariate analysis model

2004

View full text Add to dashboard Cite

DRE. Overall, 49 patients had a transurethral resection of the prostate (TURP). The cancerdetection rate on extended biopsy was correlated with risk factors using the chisquare test and multivariate analysis. RESULTSExtended biopsy detected prostate cancer in 30 of the 83 men (36%), with positive cores in only 20 sextant biopsy sites (67%), in only seven in additional sites (23%), and both in three (10%). Of the 21 patients who had repeat extended biopsy, four (19%) had cancers. There were two carcinomas in the 49 TURP specimens (4%). The PSA level, DRE and transrectal ultrasonography findings were not predictive of cancer in extended biopsies (chisquare test). Patient age, PSA density and the number of cores with HGPIN (all P < 0.001) had a significant effect on the cancerdetection rate, and multivariate analysis showed that all three were independent predictors of cancer. A logistic regression model was designed to predict the probability of cancer in extended biopsy, with an overall accuracy of 78%. CONCLUSIONExtended biopsy improved the cancer detection rate by 23% in patients with HGPIN. Patient age, PSA density and the number of cores with HGPIN were the only independent predictors of cancer. KEYWORDSprostatic intraepithelial neoplasia, prostate cancer, extended needle biopsy

show abstract

Section: Discussionmentioning

confidence: 66%

Predictors of prostate cancer on extended biopsy in patients with high‐grade prostatic intraepithelial neoplasia: a multivariate analysis model

2004

View full text Add to dashboard Cite

show abstract

“…Its incidence is greater in the black race. 28 It has also been shown to occur a decade earlier in African-American men than in Caucasians. 3 In Brazil, HGPIN was found a decade earlier in African-Brazilians than in white Brazilians.…”

Section: Commentmentioning

confidence: 97%

High-grade intra-epithelial neoplasia and prostate cancer in Dibombari, Cameroon

Angwafo

Zaher

Befidi-Mengue

et al. 2003

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

High-grade prostatic intra-epithelial neoplasia (HGPIN) occurs a decade earlier in men of African descent in the US and Brazil, compared to white men. Prostate cancer incidence and mortality is worse in the African-American than in US white men. Sub-Saharan Africa was thought to be a low incidence area. This disparity has been attributed to lifestyle factors such as diet. We report the results of prostatic biopsies, from an ongoing national prostate cancer survey. One hundred and eleven men aged 40 y and over were recruited for medical interview (AUA symptom score), prostate specific antigen (PSA) assay and digital rectal examination (DRE). Between six and 10 cores of random digitally guided needle biopsies were performed on 24 subjects that had either suspicious prostates on digital rectal examination þ / or PSA 4 ng/ml. All lesions of the prostate were described on routine histopathology. The Gleason score and proportion of tissue involved with cancer, was determined. Eight men had benign prostatic hyperplasia (BPH), six had cancer, another six had low grade intra-epithelial neoplasia, two had HGPIN, there was one case of BPH and chronic prostatitis and one case of chronic prostatitis only. The cancer patients were aged 58 -75 y (mean 66.93 y). Gleason scores ranged from 5 to 9, there was one score of 3. Cancer made up 20 -80% tissue samples. HGPIN was found in two cases (mean age 58 y). Significant prostate cancer and the pre-cancerous lesion HGPIN exist in Dibombari, Cameroon. The purported low incidence of prostate cancer may reflect cultural and economic barriers to health care.

show abstract

“…Mohler et al examined androgen in prostate tissue of African American and white men who had received radical prostatectomy for prostate cancer; they found no differences in tissue levels of testosterone and DHT by race. However, high-grade prostatic intraepithelial neoplasia, a precursor of prostate cancer, was found to be a significant predictor of prostate cancer (Carver et al, 2004) and is more common in African American men than in white men (Fowler, Bigler, Lynch, Wilson, & Farabaugh, 2001). (2007) American Cancer Society (2006) American College of Physicians (1997) American College of Preventive Medicine (Ferrini & Woolf, 1998) American College of Radiology (Ferrini & Woolf, 1998) American Medical Association (2001) American Society of Internal Medicine (U.S. Preventive Services Task Force, 2002) Insufficient evidence exists on which to make a recommendation for or against routine screening for prostate cancer using prostate-specific antigen (PSA) testing or digital rectal examination (DRE).…”

Section: Pathophysiologymentioning

confidence: 99%

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

Jones

Underwood

Rivers

2007

Clinical Journal of Oncology Nursing

View full text Add to dashboard Cite

Prostate cancer is the most commonly diagnosed cancer in men in the United States. It disproportionately affects African American men when compared to other ethnic groups. African American men are two to three times more likely to die of prostate cancer than white men. The reasons for the disparity remain unclear, but several factors may be involved, such as age, race, nationality, nutrition, exercise, and family history of cancer. Detection of prostate cancer in high-risk African Americans is important but continues to be controversial. This article reviews the current issues and challenges regarding prostate cancer in African American men. Nurses play a vital role in the health care and education of patients; therefore, they must be aware of the issues.

show abstract

Prospective study of correlations between biopsy-detected high grade prostatic intraepithelial neoplasia, serum prostate specific antigen concentration, and race

Cited by 34 publications

References 36 publications

Predictors of prostate cancer on extended biopsy in patients with high‐grade prostatic intraepithelial neoplasia: a multivariate analysis model

Predictors of prostate cancer on extended biopsy in patients with high‐grade prostatic intraepithelial neoplasia: a multivariate analysis model

High-grade intra-epithelial neoplasia and prostate cancer in Dibombari, Cameroon

Reducing Prostate Cancer Morbidity and Mortality in African American Men: Issues and Challenges

Contact Info

Product

Resources

About