Prospective Study of Cancer in Patients With Hypogammaglobulinaemia

The diagnosis and treatment of posttransplant lymphoproliferative disorders

“…Other similar studies have also found increases in gastric carcinomas in these patients. lIB , 138 The general estimation of a 10% incidence of cancer in congenitally immunodeficient patients, such as those with Wiskott Aldrich syndrome, or ataxia telangiectasia, has also been upheld. 194 A separate line of criticism against immunosurveillance concerned the development of tumors in nude mice.…”

Nitrite Accumulatin during Anaerobic Nitrate Reduction by Binary Suspensions of Bacteria Isolated from the Achlorhydric Stomach

“…Although nitrite is found in gastric juice from both types of patient, the highest concentrations detected in hypogammaglobulinaemic patients, 1 mM, is tenfold greater than the 0.1 m~ maximum nitrite concentration detected in pernicious anaemic patients (Dolby et al, 1984;Forsythe et al, 1987). This correlates with the observation that hypogammaglobulinaemic patients are ten times more prone to gastric cancer than those with pernicious anaemia and 50 times more prone than the general population (Kinlen et al, 1985).…”

“…The achlorhydric stomach provides an environment which might favour bacterial formation of N-nitroso compounds because there is an established bacterial flora predominated by streptococci, an input of salivary and dietary nitrate and the pH is nearly neutral. Nitrite has been shown to accumulate in the gastric juice of achlorhydric patients, so this might be a contributing factor to their raised incidence of gastric cancer compared with the general population (Dolby et al 1984;Kinlen et al 1985). Forsythe et al (1987) identified the predominant nitrate-reducing and nitrite-reducing bacteria from the achlorhydric stomach and determined the nitrate reductase and nitrite reductase activities of washed cell suspensions of these organisms.…”

von Recklinghausen Disease in a Patient with X-linked Agammaglobulinemia.

“…1%, including lymphoma, gastric cancer and colorectal cancer (4, 13). Kinlen et al (14) reported a 47-fold increase of gastric cancer and a 30-fold increase of lymphomasamong patients with commonvariable immunodeficiency (CVID), which is one of the primary hypogammaglobulinemic diseases, van der Meer et al reported that the calculated incidence of colorectal cancer was 30-fold higher in patients with XLA (15). The absence of mucosal immunoglobulin may lead to chronic inflammation and carcinogenesis of gastrointestinal mucosa.…”