Prospective study of caffeine consumption and risk of Parkinson's disease in men and women

Abstract

Results of case-control studies and of a prospective investigation in men suggest that consumption of coffee could protect against the risk of Parkinson's disease, but the active constituent is not clear. To address the hypothesis that caffeine is protective against Parkinson's disease, we examined the relationship of coffee and caffeine consumption to the risk of this disease among participants in two ongoing cohorts, the Health Professionals' Follow-Up Study (HPFS) and the Nurses' Health Study (NHS). The study population comprised 47,351 men and 88,565 women who were free of Parkinson's disease, stroke, or cancer at baseline. A comprehensive life style and dietary questionnaire was completed by the participants at baseline and updated every two to four years. During the follow-up (10 years in men, 16 years in women), we documented a total of 288 incident cases of Parkinson's disease. Among men, after adjustment for age and smoking, the relative risk of Parkinson's disease was 0.42 (95% CI: 0.23-0.78; p for trend < 0.001) for men in the top one-fifth of caffeine intake compared to those in the bottom one-fifth. An inverse association was also observed with consumption of coffee (p for trend = 0.004), caffeine from noncoffee sources (p for trend < 0.001), and tea (p for trend = 0.02) but not decaffeinated coffee. Among women, the relationship between caffeine or coffee intake and risk of Parkinson's disease was U-shaped, with the lowest risk observed at moderate intakes (1-3 cups of coffee/day, or the third quintile of caffeine consumption). These results support a possible protective effect of moderate doses of caffeine on risk of Parkinson's disease.

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

“…Similarly, a strong inverse relationship of PD with coffee and total caffeine intake was reported in the Health Professionals Follow-up Study, a cohort of men (RR 0.42, 95% CI 0.23-0.78 for highest versus lowest quintile, p for trend <0.001) [478]. In the Nurses Health Study, a cohort of women, there was no significant association between total caffeine intake and PD overall (p for trend 0.6), but an apparent U-shaped relationship, with lowest risk among women with moderate caffeine intake (1-3 cups of coffee per day) [478].…”

“…In the Health Professionals Follow-up Study [478], there was an inverse association between tea intake and PD in men who did not drink coffee (RR 0.4, 95% CI 0.2-1.2 for more than one cup per day versus none, p for trend 0.02), but no association in women. The results were similar for other caffeinated beverages [478].…”

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

“…Factors decreasing the risk of developing PD can also provide valuable clues to understand its etiology. Evidence that cigarette smoking, caffeine and tea intakemayreduce the risk for PD development appears clear, but there is still uncertainty over their exact role in the disease [36,37].…”

Compostos bioativos e atividade antioxidante do café conilon submetido a diferentes graus de torra

“…5 Existe uma vasta literatura que relata o potencial dos compostos bioativos ou componentes funcionais na ação contra os males da hipertensão, doenças cardiovasculares, câncer entre outras. [8][9][10][11][12][13][14][15][16][17][18][19][20] Além da cafeína, o café apresenta outras substâncias bioativas como a trigonelina, compostos fenólicos (em que se destacam os ácidos clorogênicos) e compostos resultantes da reação de Maillard, como as melanoidinas. 21,22 Os compostos fenólicos constituem uma das principais classes de antioxidantes naturais.…”