Prospective Screening for Down Syndrome Using Maternal Serum Afp

Baumgarten, A.; Schoenfeld, Myron R.; Mahoney, Maurice J.; Greenstein, Robert M.; Saal, Howard M.; Nelson, Mia; Petersen, E.M.

doi:10.1016/s0140-6736(85)92355-4

Cited by 38 publications

(11 citation statements)

References 6 publications

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“…The median AFAFP value from 27 pregnancies with trisomy 21 was found to be 0.60 MoM (p<O.001) (Cuckle et al, 1984). Based on this and similar findinqs (Tabor et al, 1984: Triq et al, 1984: Baumgarten et al, 1985: Nelson et al, 1985: Hershey et al, 1985and Jones et al, 1986) an anonymous editorial (Lancet, 1985) (Nicolini, 1988). This finding suggests that placental or membrane passage of AFP from fetal to maternaI compartments rather than decreased fetal synthesis is the cause for reduced levels of MSAFP in Down syndrome pregnancies (Nicolini, 1988).…”

Section: Association Between Msafp Afafp and Trisomymentioning

confidence: 76%

“…They cite an example from Baumgarten et al (1985), whose centre offers amniocentesis to women under the age of 35 based on a low MSAFP value equivalent to a Down syndrome risk of at least 1:250. Their expected ratio of normal fetal loss/Down syndrome cases detected was 0.3.…”

Section: Association Between Msafp Afafp and Trisomymentioning

confidence: 99%

“…The studies that associated low MSAFP values wi th the risk for fetai chromosomal abnormalities have virtually aIl been performed retrospectively with the exception of Tabor et al (1984) and Baumgarten et al (1985). The variation in the…”

Section: Retrospective Versus Prospective Studiesmentioning

confidence: 99%

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Genetic control of the survival of murine trisomy 16 fetuses

Epstein

Vekemans

1990

Teratology

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A mouse model that allows for the experimental induction of an aneuploid state has been employed to invest "Lgate the factors that control the survi" a~" of trisomy 16 fet.uses. The prevalence of trisomy 16 fetuses on day 15 of gestation was shown to vary significantly with the genetic background of the female parent.The ability to spontaneously abort a trisomy 16 conceptus was shawn to be higher in the mouse strain with a low prevalence of trisomy 16, compared to those mouse strains wi th a high prevalence of trisomy 16. Furthermore, the maternaI ability that selects against, or promotes the survival of a trisomie conceptus was shown to be specifie for the trisomy in question.

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Section: Association Between Msafp Afafp and Trisomymentioning

confidence: 76%

Section: Association Between Msafp Afafp and Trisomymentioning

confidence: 99%

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Genetic control of the survival of murine trisomy 16 fetuses

Epstein

Vekemans

1990

Teratology

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“…Studies have demonstrated the benefit of combining maternal age and a low MSAFP to identify Down syndrome fetuses in women younger than 35 years old [5][6][7][8][9][10][11][12], Other biochemical markers (beta-human chorionic gonadotro pin, p-HCG; unconjugated estriol, UEj) in combination with the MSAFP (triple screen) have further improved the Down syndrome detection rate [13].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the Biparietal Diameter/Femur Length Ratio to Detect Down Syndrome in Patients with an Abnormal Biochemical Screen

et al. 1994

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Abnormal fetal biometry is considered a marker for fetal trisomy. We prospectively evaluated the biparietal diameter/femur length ratio to identify Down syndrome fetuses. This ratio was calculated when women (< 35 years old) underwent an amniocentesis for an abnormal biochemical screen for Down syndrome. Using reported ratio cut-offs (> 1.5 SD above the mean), the ratio had a sensitivity of 50% (3/6), specificity of 92% (244/264), positive predicitive value of 13% (3/23), negative predictive value of 99% (244/247), and a relative risk of 10.8. Using our own population ratio, a cut-off > 1.5 SD had a sensitivity of 50% (3/6), specificity of 94% (249/252), positive predictive value of 17% (3/18), negative predictive value of 99% (249/252) and a relative risk of 13.9. A lower cut-off decreased the efficacy to detect Down syndrome. A ratio > 1.5 SD above the mean is a useful adjunct to identify Down syndrome in pregnancies at risk by an abnormal biochemical screen.

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“…Alpha-fetoprotein (AFP) is measured to screen for foetal neural tube defects (NTP) (1) and Down's syndrome in early pregnancy (2). Further, measurement of AFP is useful diagnostically with embryonic tumours of the ovary and testis (3), and primary liver cancer (4).…”

Section: Introductionmentioning

confidence: 99%

Chemiluminescent enzyme immunoassay for alpha‐fetoprotein using β‐D‐galactosidase as label and 5‐bromo‐4‐chloro‐3‐indolyl‐β‐D‐galactopyranoside as substrate

Arakawa¹,

Ikegami²,

Maeda³

et al. 1993

J. Biolumin. Chemilumin.

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We developed a sensitive chemiluminescent sandwich-type enzyme immunoassay (CL-EIA) of alpha-fetoprotein (AFP) using beta-D-galactosidase (beta-gal) as a label and 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside as a substrate. The CL-EIA for AFP was performed using two monoclonal antibodies, one antibody is labelled with beta-gal, the other is coated onto the inside surface of a polystyrene tube. The detection limit for AFP was 0.5 ng/mL, equivalent to 10 pg/assay tube. The coefficient of variation for within and between assay imprecision were 2.0%-4.9% (n = 10) and 4.4%-9.8% (n = 5), respectively. AFP values in serum determined by this method correlated well with those obtained by radioimmunoassay (n = 26, r = 0.99). This sensitive AFP assay can be performed within 4 h and can be used as a routine assay in clinical diagnosis.

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Prospective Screening for Down Syndrome Using Maternal Serum Afp

Cited by 38 publications

References 6 publications

Genetic control of the survival of murine trisomy 16 fetuses

Genetic control of the survival of murine trisomy 16 fetuses

Efficacy of the Biparietal Diameter/Femur Length Ratio to Detect Down Syndrome in Patients with an Abnormal Biochemical Screen

Chemiluminescent enzyme immunoassay for alpha‐fetoprotein using β‐D‐galactosidase as label and 5‐bromo‐4‐chloro‐3‐indolyl‐β‐D‐galactopyranoside as substrate

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