Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari, Kanchan; Chainy, G.B.N.; Subudhi, Umakanta

doi:10.1016/j.heliyon.2020.e05712

Cited by 35 publications

(25 citation statements)

References 195 publications

(196 reference statements)

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“…As shown, the circles of correlation confirm the results displayed in Fig. 1, in which variables FT3, FT4 and total cholesterol are dependent on the presence of Dim2, those related to organ damage and inflammation are dependent on the presence Dim1 and the variables TyG index and triglycerides are dependent on the Dim3 T3 syndrome, which is considered a useful adaptation to preserve energy during critical illness [24][25][26][28][29][30]. As in our children, patients with critical illness experience a concomitant weight loss due to a hypercatabolic state [33].…”

Section: Discussionsupporting

confidence: 83%

“…A second potential explanation is systemic immune activation in response to SARS-CoV-2 infection may cause thyroid damage. A third hypothesis is a selective transient pituitary dysregulation, due to both the direct cytotoxic effect of the virus at the pituitary level and an indirect effect via the activation of proinflammatory cytokines, which produce a "cytokine storm" that would, in turn, induce NTIS [24][25][26][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

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Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children

Calcaterra

Biganzoli

Dilillo

et al. 2021

J Endocrinol Invest

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Purpose COVID-19 disease may result in a severe multisystem inflammatory syndrome in children (MIS-C), which in turn may alter thyroid function (TF). We assessed TF in MIS-C, evaluating its impact on disease severity. Methods We retrospectively considered children admitted with MIS-C to a single pediatric hospital in Milan (November 2019–January 2021). Non-thyroidal illness syndrome (NTIS) was defined as any abnormality in TF tests (FT3, FT4, TSH) in the presence of critical illness and absence of a pre-existing hormonal abnormality. We devised a disease severity score by combining severity scores for each organ involved. Glucose and lipid profiles were also considered. A principal component analysis (PCA) was performed, to characterize the mutual association patterns between TF and disease severity. Results Of 26 (19 M/7F) patients, median age 10.7 (IQR 5.8–13.3) years, 23 (88.4%) presented with NTIS. A low FT3 level was noted in 15/23 (65.3%), while the other subjects had varying combinations of hormone abnormalities (8/23, 34.7%). Mutually correlated variables related to organ damage and inflammation were represented in the first dimension (PC1) of the PCA. FT3, FT4 and total cholesterol were positively correlated and characterized the second axis (PC2). The third axis (PC3) was characterized by the association of triglycerides, TyG index and HDL cholesterol. TF appeared to be related to lipemic and peripheral insulin resistance profiles. A possible association between catabolic components and severity score was also noted. Conclusions A low FT3 level is common among MIS-C. TF may be useful to define the impact of MIS-C on children’s health and help delineate long term follow-up management and prognosis.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Non-thyroidal illness syndrome and SARS-CoV-2-associated multisystem inflammatory syndrome in children

Calcaterra

Biganzoli

Dilillo

et al. 2021

J Endocrinol Invest

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“…Thyrotoxicosis without neck pain (possibly in the context of the nonthyroidal illness syndrome) could characterize more severe and critical cases of COVID-19 pneumonia. Some clues of the hormonal changes (i.e., low T3 and TSH concentrations) and overt thyrotoxicosis to be regarded as predictors of poor outcome of COVID-19 are already emerging Kumari [ 14 ] To explore the potential role of prevailing thyroid disorders in SARS-CoV-2 infection Thyroid dysfunction may have considerable risk in aggravating the infection and spread of SARS-CoV-2, and it is closely associated with aging Chen [ 15 ] To review the potential interaction between COVID-19 and the thyroid gland, including thyroid pathology, function and diseases. To explore the potential harmful effects of COVID-19 drugs on the thyroid SAT caused by SARS-CoV-2 has been reported.…”

Section: Resultsmentioning

confidence: 99%

“… Thyroid disease should not be considered a risk factor for SARS-CoV-2 infection 12 , 16 Has the management of thyroid patients to be adapted in presence of SARS-CoV-2 infection? Data on the indication for monitoring thyroid patients when infected by SARS-CoV-2 are unclear and the need of thyroid follow-up is not supported 12 , 14 , 15 , 16 COVID-19 coronavirus disease 2019, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, SAT subacute thyroiditis …”

Section: Resultsmentioning

confidence: 99%

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Thyroid sequelae of COVID-19: a systematic review of reviews

Trimboli

Camponovo

Scappaticcio

et al. 2021

Rev Endocr Metab Disord

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The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to cause multi-organ effects including endocrine disorders. The impact of COVID-19 on the thyroid gland has been described but several aspects have to be clarified. The systematic review was conceived to achieve more solid information about: 1) which thyroid disease or dysfunction should be expected in COVID-19 patients; 2) whether thyroid patients have a higher risk of SARS-CoV-2 infection; 3) whether the management has to be adapted in thyroid patient when infected. The literature was searched by two authors independently. A 5-step search strategy was a priori adopted. Only reviews focused on the relationship between thyroid and COVID-19 were included. The last search was performed on February 21st 2021. Two-hundred-forty-seven records was initially found and nine reviews were finally included. The reviews identified several potential thyroid consequences in COVID-19 patients, such as thyrotoxicosis, low-T3 syndrome and subacute thyroiditis, while no relevant data were found regarding the potential impact of COVID-19 on the management of patients on thyroid treatment. The present systematic review of reviews found that: 1) patients diagnosed with COVID-19 can develop thyroid dysfunction, frequently non-thyroidal illness syndrome when hospitalized in intensive care unit, 2) having a thyroid disease does not increase the risk for SARS-CoV-2 infection, 3) thyroid patients do not need a COVID-19-adapted follow-up. Anyway, several factors, such as critical illness and medications, could affect thyroid laboratory tests.

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