Aim: To answer the clinical question 'In infants about to be delivered and admitted to neonatal units, what clinical practice strategies, compared to standard care, have been shown to decrease incidence rates of intraventricular haemorrhage (IVH)?' Methods: MEDLINE via Ovid were searched for relevant articles. Results: A total of 478 articles, after the removal of duplicates, were found and screened by title and abstract. Forty full-text articles were subsequently reviewed, and 19 were included as relevant to the structured clinical question. An additional article was included based on expert advice. Conclusion: There are various levels of research evidence for clinical practice strategies to decrease the incidence rates of IVH. Higher-quality evidence suggests that antenatal corticosteroids decrease the rates of IVH, and multiple evidence-based intervention bundles implemented in the neonatal unit are associated with decreased rates of IVH.A primiparous woman has prematurely ruptured her membranes at 25 weeks' gestation, and she is expected to deliver within the next week. It is known that this baby is at a high risk of intraventricular haemorrhage (IVH) due to prematurity. The treating team wish to minimise the chance of an IVH. What is the evidence for specific clinical practice strategies that may decrease the risk of an IVH in this situation?
Structured Clinical QuestionIn an expected preterm infant who is about to be delivered at 25 weeks' gestation and then admitted to a neonatal unit (patient), what clinical practice strategies (intervention) lead to decreased rates of any grade of IVH (outcome)?