Prospective relations between Helicobacter pylori infection, coronary heart disease, and stroke in middle aged men.

Abstract

Objective-To determine whether Helicobacter pyloni, a chronic bacterial infection often acquired in childhood, is associated with increased risk of coronary heart disease and stroke later in life. Design-Nested case-control study. Setting-Prospective study of cardiovascular disease in men aged 40-59 years at entry (1978-1980) (Heart 1996;75:568-572) Keywords: coronary heart disease; Helicobacter pylori; stroke Factors acting early in life may influence adult risk of coronary heart disease,1 2 and play a part in determining its social class distribution.3 Helicobacterpylori (Hpylon) is a chronic bacterial infection which is usually acquired in childhood, particularly in socially deprived circumstances.45 Its associations with peptic ulcer disease and gastric cancer are well recognised -8; both of these conditions are associated with coronary heart disease.9 10 A recent case-control study based on prevalent coronary heart disease in middle aged men provided some support for the possibility of an association between H pylon and coronary heart disease." However, selection biases could not be excluded in that study, and only limited information was available on potential confounding factors. The problems of selection bias were addressed in a further crosssectional study in south London men, which found a strong relation between H pylon seropositivity and electrocardiographic abnormalities suggestive of myocardial ischaemia or infarction, independent of a wide range of confounding variables.'2 However, no study has yet prospectively investigated the relation between H pylon infection and coronary heart disease. We have used a nested case-control study based on a longitudinal study of cardiovascular disease in middle aged men to examine the relation between H pylon seropositivity and subsequent coronary heart disease and stroke.

Pathogen Burden in Essential Hypertension

“…[8][9][10][11]13 The OR of Coxsackie virus infection with HT was 3.17 after adjustment for age, male gender, drinking status, overweight, dyslipidemia, and log-CRP level. Coxsackie virus, a member of the enterovirus genus, is the most common cause of human myocarditis.…”

<I>HELICOBACTER PYLORI</I> INFECTION IN NEVER-SMOKING MALE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATION TO LUNG FUNCTION

“…Helicobacter pylori (H. pylori) is a microaerophilic spiral-shaped gram negative bacterium that chronically infects the stomach of more than 50% of the human population (varying from over 70% in developing countries to less than 40% in developed countries) and represents the major cause of gastroduodenal pathologies Science Publications AJI (e.g., chronic active gastritis, peptic ulcer, B-cell lymphoma and gastric carcinoma) (Wotherspoon et al, 1999;Parsonnet et al, 1991;D'Elios et al, 1997). Some recent epidemiologic and serologic studies have reported a relationship between H. pylori seropositivity, especially of the high virulent cytotoxin-asssociated gene A (CagA) positive strains and extra-gastroduodenal diseases, such as vascular (coronary artery disease and stroke), metabolic (autoimmune atrophic thyroiditis), rheumatic (Henoch-Schönlein purpura), dermatologic (chronic urticaria and rosacea), as well as respiratory diseases (chronic bronchitis, COPD, bronchiectasis, asthma and lung cancer) (Whincup et al, 1996;Luis et al, 1998;Tsang et al, 1998;Roussos et al, 2006;Jun et al, 2006;Behroozian and Moradkhan, 2010). The activation of inflammatory mediators as a result of systemic immune response induced by H. pylori infection may be potential explanation for these associations (Kanbay et al, 2007).…”

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

“…Some reports have shown a positive relation between HP infection and coronary heart disease [6][7][8] , while others have found no such relationship 2,[9][10][11] . In regards to the relation between HP infection and stroke, positive 12) and negative 13) test results have been reported. It has also been reported that the eradication of HP and antibiotics against HP reduced the recurrence rate of acute coronary events 14,15) .…”