1997
DOI: 10.1378/chest.112.2.430
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Prospective Randomized Trial of Talc Slurry vs Bleomycin in Pleurodesis for Symptomatic Malignant Pleural Effusions*

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Cited by 142 publications
(101 citation statements)
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References 24 publications
(9 reference statements)
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“…Stage IV lung cancer confers a poor prognosis, particularly when it co-occurs with pleural effusion (14). In recent years, there have been advancements in techniques that can preserve lung function, such as talc pleurodesis (12). The identification of genetic mutations associated with lung cancer (EGFR, anaplastic lymphoma receptor tyrosine kinase and ROS proto-oncogene 1 receptor tyrosine kinase) and the availability of biological drugs that are less toxic, better tolerated and more effective is improving the prognosis of patients with lung cancer, at least in the short term (5-7).…”
Section: Discussionmentioning
confidence: 99%
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“…Stage IV lung cancer confers a poor prognosis, particularly when it co-occurs with pleural effusion (14). In recent years, there have been advancements in techniques that can preserve lung function, such as talc pleurodesis (12). The identification of genetic mutations associated with lung cancer (EGFR, anaplastic lymphoma receptor tyrosine kinase and ROS proto-oncogene 1 receptor tyrosine kinase) and the availability of biological drugs that are less toxic, better tolerated and more effective is improving the prognosis of patients with lung cancer, at least in the short term (5-7).…”
Section: Discussionmentioning
confidence: 99%
“…The presence of pleural effusion, a common manifestation of NSCLC, worsens the prognosis of patients (12,13). The management of pleural effusions is crucial for improving the patient's quality of life and prognosis (12).…”
Section: Discussionmentioning
confidence: 99%
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“…Shaw et al in their Cochrane meta-analysis showed that talc was associated with a significantly better chance of success than any other agent [1]. A prospective, randomized trialconcluded that bleomycin is as effective as talc, but the agent iscostly [20]. A meta-analysis comparing talc, bleomycin, tetracycline/ doxycycline, C. parvum extract, and mitozatrone did not find one agent that was significantly better than the others, although the trend was toward better success with talc [21].…”
Section: Discussionmentioning
confidence: 99%