Prospective randomized study to compare frozen-thawed embryo transfer cycles outcome in women with functioning ovaries and hrt for endometrium preparation with or without prior GnRHa suppression

Ramos, J.; Caligara, C.; Tocino, A.; Rodríguez, Isabel; Carranza, F.; Sánchez, Manuel Fernández

doi:10.1016/j.fertnstert.2007.07.370

Cited by 7 publications

(4 citation statements)

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“…The clinical pregnancy rate is a common outcome measured in comparative effectiveness research. Our results are in line with previously published prospective randomized studies [10][11][12][13] . In those studies, endometrial preparation for FET administered exclusively on steroids, appears to be as effective as the conventional regiment involving desensitization using GnRH agonist with regard to clinical pregnancy rates.…”

Section: Discussionsupporting

confidence: 93%

“…In one RCT, HRT with GnRH agonist pre-treatment was reported to achieve signi cant higher pregnancy rate and live birth rate than HRT only 9 . The result contradicted other RCTs, which failed to demonstrate any bene cial use of the GnRH agonist in terms of clinical pregnancy rate [10][11][12][13] . However, those RCTs have several limitations.…”

Section: Introductionmentioning

confidence: 62%

“…Another possible explanation may be the slightly higher early miscarriage rate in the agonist group. The other three studies also revealed an increase in the miscarriage rate in agonist group, but live birth rate didn't measured in those studies 10,11,13 . The clinical pregnancy rates and live birth rates remained high in both group after three or more FET cycles.…”

Section: Discussionmentioning

confidence: 88%

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Endometrial Preparation for Frozen–Thawed Embryo Transfer With or Without Pretreatment With Gonadotropin-Releasing Hormone Agonist in Regular Menstrual Cycles: Results of a Retrospective Cohort Study

Wei

Liu

Dong

et al. 2021

Preprint

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ObjectsTo compare the treatment outcomes of FET in hormonal replacement treatment (HRT) protocol with and without long-acting gonadotropin-releasing hormone agonist (GnRHa) pretreatment in patients with regular menstrual cycles. MethodsA total of 5049 patients from three centers were recruited in this retrospective study. The study population was divided into two groups. In HRT with GnRHa group, endometrial preparation with supplement estrogen 6mg daily initiated following down-regulation of long-acting GnRH agonist. In HRT group, the same dose of estrogen administration only for two weeks. Live birth rates were the primary outcomes measured in both groups. ResultsThere were no differences in implantation rate, β-HCG positive rate, clinical pregnancy rate, and early miscarriage rate between the two groups. The ongoing pregnancy rate and the live birth rate were higher in HRT group compared to the agonist group (47.3% vs 42.7% and 44.7% vs 39.8%, respectively). However, the co-treatment with GnRH agonist in HRT protocol was not associated with clinical pregnancy rate (OR 0.94; 95% CI 0.78 to 1.12) and live birth rate (OR 0.82; 95% CI 0.71 to 1.02) after logistic regression analysis. In the first FET cycle, patients in HRT group achieved higher clinical pregnancy rate and live birth rate. In addition, there was no differences in clinical pregnancy rate and live birth rate between the two groups in standard patients.ConclusionsThe HRT protocol for FET seems to be as effective as the HRT protocol involving preliminary pituitary suppression with GnRH agonist in regular menstrual cycles.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 88%

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Endometrial Preparation for Frozen–Thawed Embryo Transfer With or Without Pretreatment With Gonadotropin-Releasing Hormone Agonist in Regular Menstrual Cycles: Results of a Retrospective Cohort Study

Wei

Liu

Dong

et al. 2021

Preprint

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“…El-Toukhy et al found improved pregnancy rates in FET cycles with the use of buserelin for downregulation. 68 However, multiple studies failed to show any difference in outcomes with the addition of GnRH agonists, 59,76,77 and the Cochrane review 2 failed to demonstrate an overall benefit of adding GnRH agonists to cycle regimens.…”

Section: Strategies For Inadequate Endometrial Responsementioning

confidence: 99%

Cryopreserved Embryo Transfer: Endometrial Preparation and Timing

Burks

Paulson

2015

Semin Reprod Med

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The objective of this article was to review and synthesize information from the scientific literature pertaining to the preparation of endometrium for cryopreserved embryo transfer. This article is a critical review of selected scientific literature, synthesis, and formulation of opinion. Estrogen and progesterone are necessary and sufficient to induce endometrial receptivity in cryopreserved embryo transfer cycles. A variety of regimens have been described including natural cycles using endogenous ovarian hormones and artificial or programmed cycles with exogenously administered steroid hormones. To achieve optimal synchrony between embryo and endometrium, the timing of progesterone administration needs to be adjusted to the developmental stage of the thawed embryos. There is currently no evidence that any single regimen or adjuvant substance results in superior outcomes in cryopreserved embryo transfer cycles, although timing of progesterone administration does matter. Although no single regimen of endometrial preparation for cryopreserved embryo transfer has been proven superior to the others, the relative convenience and ease of use do vary, depending on the route of administration chosen and any adjuvant added to the cycle.

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