Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty

Hernigou, Jacques; Valcarenghi, Jérôme; Callewier, Antoine; Lucile, Sohm; Decottenier, Valérie; Ledoux, A; Kyriakidis, Theofylaktos; Bath, Olivier

doi:10.1007/s00264-020-04936-9

Cited by 14 publications

(12 citation statements)

References 15 publications

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“…In 2021, Jacques et al . 47 verified that the incidence of CRPS I after total knee arthroplasty was 13%. Therefore, they suggested that doctors should closely monitor CRPS I and provide appropriate interventions as early as possible in patients undergoing arthroplasties.…”

Section: Discussionmentioning

confidence: 81%

“…Given the lack of a control conservative treatment group, we cannot determine whether radial head arthroplasty exerts an influence on the progression of CRPS I. In 2021, Jacques et al 47 verified that the incidence of CRPS I after total knee arthroplasty was 13%. Therefore, they suggested that doctors should closely monitor CRPS I and provide appropriate interventions as early as possible in patients undergoing arthroplasties.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Determinants of Complex Regional Pain Syndrome Type I among Radial Head Fracture Patients with Unilateral Arthroplasty

Wang

Jiang

Dai

et al. 2022

Orthopaedic Surgery

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Objective This study aims to assess the proportions of complex regional pain syndrome type I (CRPS I) in radial head fracture patients undergoing unilateral arthroplasty and to explore associated factors. Methods This is a prospective observational study. From March 2016 to May 2019, a total of 221 adult patients with radial head fracture patients were included in consecutive studies and completed the 1‐year follow‐up. All patients were treated by unilateral arthroplasty. At each follow‐up visit, the visual analogue scale was used to measure patients' pain level. Occurrence of CRPS I, which was diagnosed by Budapest criteria, was the main outcome collected at baseline and the 1‐, 3‐, 6‐, and 9‐month follow‐ups. The baseline data were collected before surgery and included demographic and clinical data. Independent t ‐tests and χ 2 tests were used as univariate analyses to compare the baseline data of patients with and without CRPS I. Multivariate analysis (Backword‐Wald) was used to identify factors independently associated with CRPS I. Results The proportion of CRPS I cases among radial head fracture patients undergoing unilateral arthroplasty was 11% ( n = 24). A total of 19 (79%) patients were diagnosed with CRPS I within 1 month after surgery. Multivariable logistic regression analysis revealed that female gender (odds ratios [OR]: 1.537; 95% confidence interval [CI]: 1.138–2.072), age younger than 60 years (OR: 1.682; 95% CI: 1.246–2.267), moderate and severe Mayo Elbow Performance Score (MEPS) pain (OR: 3.229; 95% CI: 2.392–4.351) and anxiety (OR: 83.346; 95% CI: 61.752–112.320) were independently associated with CRPS I. Conclusions This exploratory study reported that the incidence of CRPS I developing after radial head arthroplasty was 11%. Female sex, younger age, moderate and severe MEPS pain and anxiety patients seems more likely to develop CRPS I.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Determinants of Complex Regional Pain Syndrome Type I among Radial Head Fracture Patients with Unilateral Arthroplasty

Wang

Jiang

Dai

et al. 2022

Orthopaedic Surgery

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“…However, in a double-blind, placebo-controlled, randomized trial, oral ascorbic acid was found to significantly reduce the incidence of knee arthrofibrosis 1 year following injury [34]. Moreover, the consumption of vitamin C has been reported to reduce complex regional pain syndrome after total knee arthroplasty [35]. Finally, we have previously shown that E8002 inhibits peripheral nerve adhesion by increasing the fibrinolytic effects of ascorbic acid [23].…”

Section: Discussionmentioning

confidence: 97%

E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis

Takada

Setoyama

Norimatsu

et al. 2022

IJMS

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Knee arthrofibrosis is a common complication of knee surgery, caused by excessive scar tissue, which results in functional disability. However, no curative treatment has been established. E8002 is an anti-adhesion material that contains L-ascorbic acid, an antioxidant. We aimed to evaluate the efficacy of E8002 for the prevention of knee arthrofibrosis in a rat model, comprising injury to the surface of the femur and quadriceps muscle 1 cm proximal to the patella. Sixteen male, 8-week-old Sprague Dawley rats were studied: in the Adhesion group, haemorrhagic injury was induced to the quadriceps and bone, and in the E8002 group, an adhesion-preventing film was implanted between the quadriceps and femur after injury. Six weeks following injury, the restriction of knee flexion owing to fibrotic scarring had not worsened in the E8002 group but had worsened in the Adhesion group. The area of fibrotic scarring was smaller in the E8002 group than in the Adhesion group (p < 0.05). In addition, the numbers of fibroblasts (p < 0.05) and myofibroblasts (p < 0.01) in the fibrotic scar were lower in the E8002 group. Thus, E8002 reduces myofibroblast proliferation and fibrotic scar formation and improves the range of motion of the joint in a model of knee injury.

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“…Tedavisinde standart KBAS tedavileri yanında son yıllarda C vitamini tedavisi önem kazanmıştır. [28,29]…”

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Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty

Cited by 14 publications

References 15 publications

Determinants of Complex Regional Pain Syndrome Type I among Radial Head Fracture Patients with Unilateral Arthroplasty

Determinants of Complex Regional Pain Syndrome Type I among Radial Head Fracture Patients with Unilateral Arthroplasty

E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis

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