Prospective, randomized study comparing highly purified urinary follicle-stimulating hormone (FSH) and recombinant FSH for in vitro fertilization/intracytoplasmic sperm injection in patients with polycystic ovary syndrome

Aboulghar, Mohamed; Saber, Waleed; Amin, Yehia; Mansour, Ragaa; Serour, Gamal I.

doi:10.1016/j.fertnstert.2010.01.051

Cited by 10 publications

(8 citation statements)

References 9 publications

(3 reference statements)

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“…We identified 61 studies that reported clinical pregnancy. There was moderate‐quality evidence, from 13 studies involving 1551 women, that showed no significant difference in using antagonist or agonist protocols for ovarian stimulation (RR = 1.02 (95% CI, 0.91–1.15), I 2 = 7%).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Kollmann

Martins

Lima

et al. 2016

Ultrasound in Obstet & Gyne

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Section: Resultsmentioning

confidence: 99%

“…We identified 41 studies that reported on OHSS. Low‐quality evidence suggested that antagonist protocols are associated with a lower risk for developing OHSS than are agonist protocols.…”

Section: Resultsmentioning

confidence: 99%

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Kollmann

Martins

Lima

et al. 2016

Ultrasound in Obstet & Gyne

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“…According to previous studies, rFSH is more effective than uFSH in terms of number of retrieved oocytes, number of obtained embryos [ 12 ] and pregnancy rates [ 13 ]. Other studies revealed significantly higher fertilization rates and a higher number of good quality embryos when using uFSH with respect to rFSH [ 14 , 15 ]; while other data showed no significantly detectable differences in terms of number and quality of oocytes and pregnancy rates between rFSH and uFSH formulations [ 14 , 16 ]. Similarly, no significant differences were reported in terms of fertilization and pregnancy rates between uFSH and hMG [ 17 ].…”

Section: Discussionmentioning

confidence: 97%

“…In this study, we aimed to compare the effects of urinary FSH (uFSH), recombinant FSH (rFSH) and hMG formulations: although in the literature there are several studies comparing these different stimulation protocols, no unanimous results have been reported about the best one [ 12 , 13 , 14 , 15 , 16 , 17 ]. Hence, in this study, we aimed to couple the traditional markers of IVF success to data obtained by biomolecular and spectral analyses to evaluate the efficacy of different treatments.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Controlled Ovarian Stimulation Hormones on the Metabolic State and Endocannabinoid System of Human Cumulus Cells

Notarstefano

Gioacchini

Giorgini

et al. 2020

IJMS

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Different Follicle Stimulating Hormone (FSH) formulation and Luteinizing Hormone (LH) are used in Assisted Reproductive Technology (ART) to induce follicles development and oocytes maturation, but it is still under debate which protocol is to be preferred. In the present study, the different effects on cumulus cells (CCs) of three controlled ovarian stimulation (COS) protocols, based on urinary FSH, recombinant FSH, or human Menopausal Gonadotropin (hMG) administration, were assessed. CCs were obtained from 42 normal-responders women undergoing COS, randomly divided into three groups according to the used gonadotropin formulation. Differences were found in the expression of genes belonging to the endocannabinoid system (the receptors CNR1, CNR2 and TRPV1, and the enzymes involved in the metabolisms of anandamide, NAPE-PLD and FAAH, and 2-acylglycerol, DAGL and MAGL); consistently, changes in lipid (PPARα, and FASN) and carbohydrate (GLUT1 and GLUT9) metabolisms, in CCs’ macromolecules composition (highlighted by Fourier Transform Infrared Microspectroscopy, FTIRM), and in the number of retrieved oocytes were found. For the first time, statistically significant evidence on the differences related to each COS protocol on the endocannabinoid system, metabolism and macromolecular composition of CCs was found, representing a proof of concept to be further confirmed in a larger cohort of patients.

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“…A number of advantages of this product over rFSH preparations have been reported, including: significantly more top-quality embryos [26]; consumption of significantly fewer units of FSH in patients older than 39, achieving equivalent embryo development and pregnancy rates [27]; significantly higher implantation and pregnancy rates when Fostimon was administered for the first 6 days, followed by rFSH, compared to rFSH alone [28]; significantly less FSH consumption in patients achieving blastocyst transfers on day 5 [29]; and a significantly higher number of top quality embryos and transferring of cryopreserved embryos in PCO-patients [30].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Stimulation with Urofollitropin (uFSH) Results in a Lower Yield of Oocytes Compared to Recombinant FSH (rFSH), Nevertheless, uFSH is at Least as Effective as rFSH in Younger Patients: Preliminary Results of a Retrospective Study with Antagonist Protocols in an IVF/ICSI Program

Kemeter

Stroh-Weigert²,

Feichtinger³

2013

TORSJ

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Abstract:Objective: Differences in the mode of action between recombinant FSH (rFSH) and urinary derived FSH (uFSH) have been reported in cycles down-regulated by agonists. The aim of our study was to determine, if these differences also exist in cycles down-regulated by antagonists.Method: Antagonist cycles performed between 2009 -2012 were divided into two groups:1. Cycles stimulated with rFSH preparations: Follitropin alfa (n=203) and Follitropin beta (n=443) and 2. Cycles stimulated with Urofollitropin (n=405).Cetrorelix or Ganirelix were used as antagonists. All patients received 75 IU hMG additionally from day 6 of stimulation onwards up to the day of hCG administration.A logistic regression analysis was conducted to find the most significant parameters predicting hCG-positive pregnancy for 2471 IVF cycles. The results demonstrated that the predictors such as age of patients and number of cycles ever performed made negative contributions and number of oocytes retrieved and number of embryos transferred made positive contributions to prediction. Taking this into consideration, comparable groups could be created by including only firstever IVF cycles with more than 10 oocytes retrieved and 2 embryos transferred. Thus, the final sample for comparison included 98 patients in the rFSH-group and 27 patients in the uFSH group.Results: There were no differences in basic personal data and gonadotropin consumption between the groups. Stimulation with rFSH resulted in a higher yield of oocytes compared to uFSH (15,6 vs. 14,4), however, the results of the following reproductive outcome parameters were all in favor of uFSH when rFSH and uFSH were compared: oocyte maturation rate (76.5% vs. 79.0 %), fertilization rate (53,6% vs. 58,6%), embryo score 4 rate (25,7% vs.. 31,1%), hCG-positive pregnancy rate (43,9% vs. 59,3%), clinical pregnancy rate (33,7% vs. 44,4%), embryo-cryopreservation rate (19,3% vs. 30,5%) and abortion rate (14,0% vs. 12,5%). Conclusions:These results seem to support the concept that uFSH produces fewer oocytes than rFSH, but the oocytes produced by uFSH are, on an average, of better quality than those produced by rFSH. Basic studies have shown that different FSH isoforms with different elimination kinetics in the two gonadotropin preparations could be responsible for the different effects.However, the results have to be confirmed by well designed prospective randomized studies.

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Prospective, randomized study comparing highly purified urinary follicle-stimulating hormone (FSH) and recombinant FSH for in vitro fertilization/intracytoplasmic sperm injection in patients with polycystic ovary syndrome

Cited by 10 publications

References 9 publications

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome: systematic review and meta‐analysis

The Impact of Controlled Ovarian Stimulation Hormones on the Metabolic State and Endocannabinoid System of Human Cumulus Cells

Ovarian Stimulation with Urofollitropin (uFSH) Results in a Lower Yield of Oocytes Compared to Recombinant FSH (rFSH), Nevertheless, uFSH is at Least as Effective as rFSH in Younger Patients: Preliminary Results of a Retrospective Study with Antagonist Protocols in an IVF/ICSI Program

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