Prospective randomized controlled trial to compare the effect on the macula of AquaLase liquefaction and ultrasound phacoemulsification cataract surgery

Barsam, Allon; Chandra, Aman; Bunce, Catey; Whitefield, Laurence

doi:10.1016/j.jcrs.2008.02.017

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…In order to overcome surgical barriers to targeting VF, we have utilized a novel surgical energy source, referred to as Tissue Liquefaction Technology (TLT), also referred to as Phaser™ Liquefaction Technology (23). TLT was initially invented for cataract extraction and became the AquaLase® Liquefaction Device, a modality on the Infiniti Vision System by Alcon, Inc (24). In 2013, Andrew Technologies (Haddonfield, NJ/Tustin, CA) launched HydraSolve®, which is FDA cleared for SC fat removal in aesthetic body contouring and autologous fat transfer (25).…”

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confidence: 99%

Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons

Andrew¹,

Huffman

Rodríguez-Ayala

et al. 2018

Surgery for Obesity and Related Diseases

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These data provide the first demonstration of successful adipose tissue removal from the mesentery in a mammal. Importantly, we have demonstrated that when MVL is performed in obese, insulin-resistant baboons, insulin resistance is reversed, and significant weight loss occurs. Therefore, trials performing MVL in humans with abdominal obesity and related metabolic sequelae should be explored as a potential clinical tool to ameliorate insulin resistance and treat type 2 diabetes.

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mentioning

confidence: 99%

Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons

Andrew¹,

Huffman

Rodríguez-Ayala

et al. 2018

Surgery for Obesity and Related Diseases

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“…16 ), so AquaLase may carry a reduced risk over standard phacoemulsification cataract extraction for the development of PCO (ref. 20,21,[23][24][25] ). The AquaLase was primary used for liquefaction of the cataract in this study.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up of posterior capsule opacification after AquaLase and NeoSoniX phacoemulsification

Stepanov¹,

Nekolová²,

Jirásková³

et al. 2016

BIOMED PAP

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Aim.To compare the degree of posterior capsule opacification (PCO) after AquaLase and NeoSoniX phacoemulsification methods during an 8-year follow-up period using two types of software. Design. Prospective, randomized clinical trial. Methods. AquaLase was used in the right eye and NeoSoniX in the left eye of each patient with bilateral cataract. Results. Fifty patients were analyzed 1 year, 46 patients 3 years, and 37 patients 8 years after cataract surgery. Mean EPCO 2000 values were for the AquaLase group 0.324 ± 0.305 and for the NeoSoniX group 0.298 ± 0.341 (P = 0.53) 1 year after surgery, for the AquaLase group 0.582 ± 0.506 and for the NeoSoniX group 0.594 ± 0.515 (P = 0.87) 3 years after surgery, and for the AquaLase group 0.648 ± 0.567 and for the NeoSoniX group 0.673 ± 0.542 (P = 0.30) 8 years after surgery. The OSCA results were for the AquaLase group 0.7097 ± 0.3778 and for the NeoSoniX group 0.8584 ± 0.4323 (P = 0.046) 1 year after surgery, for the AquaLase group 0.9667 ± 0.736 and for the NeoSoniX group 0.9540 ± 0.5250 (P = 0.91) 3 years after surgery, and for the AquaLase group 1,035 ± 0,952 and for the NeoSoniX group 1,103 ± 0,741 (P = 0.44) 8 years after surgery. Conclusion. There was minimal PCO difference between these 2 approaches, AquaLase and NeoSoniX. Neither AquaLase nor NeoSoniX technique was able to prevent a natural progression of PCO.

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“…The advantage of Aqualase over phacoemulsification is the reduced risk of posterior capsule rupture and of thermal injury to the cornea. Aqualase is good for removing lens epithelial cells and polishing the capsule, and can reduce the risk of posterior capsular opacification [13,14,15]. This is the reason why Aqualase is well suited for refractive lens procedures and pediatric cataracts.…”

Section: Discussionmentioning

confidence: 99%

Aqualase® Revisited: Endothelial Cell Loss Strongly Depends on Lens Density

Bergholz²,

Gonnermann³

et al. 2013

Ophthalmic Res

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Purpose: To analyze the dependence between corneal endothelial cell loss by Aqualase® cataract surgery and the nuclear opalescence grade of the lens. Patients and Methods: A total of 100 eyes of 92 patients were enrolled in this prospective, single-center study. Patients were randomly assigned to the Aqualase (50 eyes) or the phacoemulsification group (50 eyes). The nuclear density was classified with the Lens Opacities Classification System III. All procedures were performed by the same surgeon. Preoperatively and 1 week postoperatively, endothelial cell counts were obtained using a noncontact specular microscope (Konan, Japan). Results: (1) Aqualase group: the group of patients with a nuclear density of 1-2 (17 patients) showed no significant endothelial cell loss (4.1%, p = 0.163). The endothelial cell loss in grade 3 cataracts (28 eyes) was 13.9% (p = 0.004) and in grade 4 cataracts (5 eyes) 69.1% (p = 0.043), being statistically significant in both groups. (2) Phacoemulsification group: in nuclear density groups 1 and 2, endothelial cell loss was 6.3% (p = 0.41), in group 3 it was 17.6% (p = 0.001) and in group 4 it was 14.9% (p = 0.08). Only in nuclear opalescence grade 4 there was a significant difference between the Aqualase and the phacoemulsification procedure (p = 0.008). Conclusion: Endothelial cell loss by Aqualase technology depends strongly on the nuclear opalescence grade. In low- and medium-density cataracts, Aqualase does not seem to provoke significant endothelial cell loss. Due to very high endothelial loss in hard nuclei, Aqualase is unsuitable for these cataracts.

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Prospective randomized controlled trial to compare the effect on the macula of AquaLase liquefaction and ultrasound phacoemulsification cataract surgery

Abstract: The results in this study suggest that AquaLase liquefaction cataract extraction is as safe as standard US phacoemulsification cataract extraction and may carry less risk for the development of postoperative cystoid macular edema. This may be most evident in diabetic patients.

Cited by 8 publications

References 15 publications

Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons

Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons

Long-term follow-up of posterior capsule opacification after AquaLase and NeoSoniX phacoemulsification

Aqualase® Revisited: Endothelial Cell Loss Strongly Depends on Lens Density

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