Prospective randomized controlled study on the validity and safety of an absorbable adhesion barrier (Interceed®) made of oxidized regenerated cellulose for laparoscopic colorectal surgery

Naito, Masanori; Ogura, Naoto; Yamanashi, Takahiro; Sato, Takeo; Nakamura, Takatoshi; Miura, Hirohisa; Tsutsui, Atsuko; Sakamoto, Yasutoshi; Tanaka, Rieko; Kumagai, Yoshito; Watanabe, Masahiko

doi:10.1111/ases.12334

Cited by 37 publications

(34 citation statements)

References 9 publications

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“…Natural polymer based antiadhesives utilize materials such as hyaluronic acid, chitosan, and carboxymethylcellulose . A number of products showed good clinical results in abdominal surgery . Most natural polymer based products, however, are biomechanically weak and degrade too quickly to be used during tendon surgery.…”

Section: Discussion and Conclusionmentioning

confidence: 99%

“…[28][29][30] A number of products showed good clinical results in abdominal surgery. [31][32][33] Most natural polymer based products, however, are biomechanically weak and degrade too quickly to be used during tendon surgery. Such limitations have led to research regarding decellularized tissue, which are both bioactive and biomechanically stronger than classic natural polymers.…”

Section: Discussionmentioning

confidence: 99%

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Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

et al. 2019

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Cartilage extracellular matrix contains antiadhesive and antiangiogenic molecules such as chondromodulin‐1, thrombospondin‐1, and endostatin. We have aimed to develop a cross‐linked cartilage acellular matrix (CAM) barrier for peritendinous adhesion prevention. CAM film was fabricated using decellularized porcine cartilage tissue powder and chemical cross‐linking. Biochemical analysis of the film showed retention of collagen and glycosaminoglycans after the fabrication process. Physical characterization of the film showed denser collagen microstructure, increased water contact angle, and higher tensile strength after cross‐linking. The degradation time in vivo was 14 d after cross‐linking. The film extract and film surface showed similar cell proliferation, while inhibiting cell migration and cell adhesion compared to standard media and culture plate, respectively. Application of the film after repair resulted in similar tendon healing and significantly less peritendinous adhesions in a rabbit Achilles tendon injury model compared to repair only group, demonstrated by histology, ultrasonography, and biomechanical testing. In conclusion, the current study developed a CAM film having biological properties of antiadhesion, together with biomechanical properties and degradation profile suitable for prevention of peritendinous adhesions.

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Section: Discussion and Conclusionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

et al. 2019

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“…Currently, several products have been approved by European and United States authorities for use in abdominal and pelvic surgery, including Seprafilm® (hyaluronate carboxymethylcellulose), Interceed® (oxidised cellulose), Adept® (icodextrin 4%), Sprayshield™ (polyethylene glycol) and Hyalobarrier® (autocrosslinked polymers of hyaluronic acid). Although there was controversy regarding the safety of these products, new systematic reviews and clinical trials have demonstrated their safety but modest efficacy [ 63 , 65 – 67 ]. Recently, Seprafilm® has been shown to reduce adhesions in a randomised clinical trial including 30 patients who underwent open abdominal surgery [ 68 ].…”

Section: Battling Adhesionsmentioning

confidence: 99%

Battling adhesions: from understanding to prevention

et al. 2019

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Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.

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“…One of the first prototypes successful in reducing postoperative adhesions in humans was Interceed ® , which was composed of modified oxidized regenerated cellulose. This particular barrier was found to be applicable following gynecologic procedures; however, its efficacy in general surgical procedures is unknown [102]. Another type of biological barrier is expanded polytetrafluoroethylene (PTFE).…”

Section: Biological Barriersmentioning

confidence: 99%

Small Bowel Obstruction in the Elderly

Morano

Bowne

2020

Principles and Practice of Geriatric Surgery

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Prospective randomized controlled study on the validity and safety of an absorbable adhesion barrier (Interceed®) made of oxidized regenerated cellulose for laparoscopic colorectal surgery

Abstract: We have shown that using Interceed in laparoscopic colorectal surgery is valid and technically safe.

Cited by 37 publications

References 9 publications

Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

Battling adhesions: from understanding to prevention

Small Bowel Obstruction in the Elderly

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