Prospective, Randomized, Controlled Clinical Trial of a Novel Matrix Hemostatic Sealant in Patients with Acute Anterior Epistaxis

Mathiasen, Ronald A.; Cruz, Raul M.

doi:10.1097/01.mlg.0000160528.50017.3c

Cited by 88 publications

(90 citation statements)

References 12 publications

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“…Common absorbable materials used for anterior packing include oxidized cellulose (e.g., Surgicel, Johnson & Johnson, New Brunswick, NJ, USA) and gelatin foams (e.g., Gelfoam, Pfizer, New York, NY, USA). Another product that combines thrombin with gelatin (e.g., Floseal, Baxter Health Care Corp, Deerfield, IL, USA) is used as a highviscosity gel for hemostasis (19). All these absorbable products are easily used and cause minimal pain and discomfort.…”

Section: Discussionmentioning

confidence: 99%

Epistaxis in geriatric patients

Yüksel¹,

Kurtaran²,

Kankılıç³

et al. 2014

Turk J Med Sci

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We studied, for the first time, the age structure of Eremias strauchi strauchi (Kessler, 1878) from a sample (18 adults) of a population living in the vicinity of Iğdır (eastern Turkey) using the skeletochronological method. The maximum observed longevity was 7 years for males and 5 years for females. The age of males ranged from 4 to 7 years (mean 4.91, n = 12), while that of females ranged from 4 to 5 years (mean 4.66, n = 6). The average snout-vent length (SVL) was 61.10 mm in males and 60.82 mm in females. The differences in mean age and SVL between sexes were not statistically significant. Intersexual differences in body size were male-biased, but this state was not statistically significant. Age and SVL were positively correlated in both sexes.

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Section: Discussionmentioning

confidence: 99%

Epistaxis in geriatric patients

Yüksel¹,

Kurtaran²,

Kankılıç³

et al. 2014

Turk J Med Sci

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“…The use of FloSeal in cardiac [9], vascular [10,11], urological [12][13][14][15], lacrimal [16], neurosurgical [17], experimental [18], and nasal/sinus [19][20][21][22][23][24] surgery has been widely reported in the literature. However, only one study using FloSealmatrix hemostatic agent in thyroid surgery has been reported to date, and this was an uncontrolled study [25].…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Testini¹,

Marzaioli²,

Lissidini³

et al. 2009

Langenbecks Arch Surg

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“…Approximately, 60 % of the populations are affected by [13,14]. Several medical and hemostatical agents can be used to manage epistaxis, including the vasoconstrictor agents' cocaine, oxymetazoline, xylometazoline, and phenylephrine [14][15][16]. Ensuring a secure airway and hemodynamic stability is important for the management of epistaxis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

Yurttaş

Şereflican

Terzi

et al. 2015

Eur Arch Otorhinolaryngol

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The aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.

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Prospective, Randomized, Controlled Clinical Trial of a Novel Matrix Hemostatic Sealant in Patients with Acute Anterior Epistaxis

Abstract: Floseal hemostatic sealant is a better tolerated, more effective, safe, and easy alternative to nasal packing in patients presenting with acute anterior epistaxis. Future studies may wish to evaluate Floseal's use in posterior epistaxis.

Cited by 88 publications

References 12 publications

Epistaxis in geriatric patients

Epistaxis in geriatric patients

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

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