Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts

McBride, Craig A.; Kimble, Roy; Stockton, Kellie

doi:10.1186/s41038-018-0135-y

Cited by 22 publications

(19 citation statements)

References 23 publications

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“…The investigators found that the three dressings performed equally well when compared. 51 Donor sites dressed with Sorbact had a mean time to re-epithelialisation of 7 days which was not statistically different compared with the other dressings, including the alginate dressing (p>0.05). There was also no statistical difference between the 3 dressings in pain scores.…”

Section: Skin Graftingmentioning

confidence: 79%

“…In a parallel three-arm prospective RCT (n=101), 51 Sorbact was compared with two other dressings, including a calcium alginate (the most commonly used donor site wound dressing), [52][53][54] in treating non-infected donor sites in paediatric split-thickness skin grafting. The investigators found that the three dressings performed equally well when compared.…”

Section: Skin Graftingmentioning

confidence: 99%

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Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Chadwick

Ousey

2019

J Wound Care

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The aim of this review was to present the clinical data on the use of the family of bacterial-binding dressings (Sorbact; dialkylcarbamoyl chloride-coated) in the treatment of a variety of acute and chronic wounds. The findings are discussed in terms of the effectiveness of the bacterial-binding dressings on bacterial bioburden reduction, infection prevention, initiation/progression of wound healing and cost-effectiveness. The evidence in support of the bacterial-binding dressings is strongest in the area of infection prevention in surgical wounds, with several controlled trials showing the prophylactic benefit of the dressing in these wounds. Wound bioburden management in chronic wounds is supported by a number of clinical studies. In total, 29 published clinical studies (with a total of 4044 patients) were included in this review.

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Section: Skin Graftingmentioning

confidence: 79%

Section: Skin Graftingmentioning

confidence: 99%

Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Chadwick

Ousey

2019

J Wound Care

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“…Time to re-epithelialization was analysed by negative binomial regression 28,29 . The ratio of means (NPWT versus control group) was reported using the incidence rate ratio (IRR) with 95 per cent confidence interval.…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial of negative pressure wound therapy as an adjunctive treatment for small-area thermal burns in children

Frear

Cuttle²,

McPhail

et al. 2020

British Journal of Surgery

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Background: The efficacy of negative pressure wound therapy (NPWT) in the acute management of burns remains unclear. The purpose of this trial was to compare standard Acticoat™ and Mepitel™ dressings with combined Acticoat™, Mepitel™ and continuous NPWT to determine the effect of adjunctive NPWT on re-epithelialization in paediatric burns. Methods: This two-arm, single-centre RCT recruited children with acute thermal burns covering less than 5 per cent of their total body surface area. The primary outcome was time to re-epithelialization. Blinded assessments were performed using photographs captured every 3-5 days until discharge. Secondary measures included pain, itch, grafting, perfusion and scar management referrals. Results: Some 114 patients were randomized. Median time to re-epithelialization was 8 (i.q.r. 7-11) days in the NPWT group and 10 (8-14) days in the control group. In a multivariable model, NPWT decreased the expected time to wound closure by 22 (95 per cent c.i. 7 to 34) per cent (P = 0⋅005). The risk of referral to scar management was reduced by 60 (18 to 81) per cent (P = 0⋅013). Four participants in the control group and one in the NPWT group underwent grafting. There were no statistically significant differences between groups in pain, itch or laser Doppler measures of perfusion. Adverse events were rare and minor, although NPWT carried a moderate treatment burden, with ten patients discontinuing early. Conclusion: Adjunctive NPWT hastened re-epithelialization in small-area burn injuries in children, but had a greater treatment burden than standard dressings alone. Registration number: ACTRN12618000256279 (http://ANZCTR.org.au).

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“…Due to their other, but no less important biotechnological properties (such as low cost, availability, and high biocompatibility), alginates are widely used in modern commercial hydrogel wound dressings in combination with metal ions for the treatment of acute and chronic wounds: diabetic ulcers, bedsores, and traumatic and surgical wounds (Algicell TM , AlgiSite TM M, Comfeel TM Plus, etc.) [88,[91][92][93][94].…”

Section: Alginatesmentioning

confidence: 99%

Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

et al. 2020

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Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on a multitude of factors. Wound treatment is a major healthcare issue that can be resolved by the development of effective and affordable wound dressings based on natural materials and biologically active substances. The proper use of modern wound dressings can significantly accelerate wound healing with minimum scar mark. Sulfated polysaccharides from seaweeds, with their unique structures and biological properties, as well as with a high potential to be used in various wound treatment methods, now undoubtedly play a major role in innovative biotechnologies of modern natural interactive dressings. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The goal of this review is to summarize available information about the modern wound dressing technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with a focus on promising and innovative designs. Future perspectives for the use of marine-derived biopolymers necessitate summarizing and analyzing results of numerous experiments and clinical trial data, developing a scientifically substantiated approach to wound treatment, and suggesting relevant practical recommendations.

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Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts

Cited by 22 publications

References 23 publications

Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Bacterial-binding dressings in the management of wound healing and infection prevention: a narrative review

Randomized clinical trial of negative pressure wound therapy as an adjunctive treatment for small-area thermal burns in children

Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

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