Prospective Randomised Controlled Trial Comparing Trigone-Sparing versus Trigone-Including Intradetrusor Injection of AbobotulinumtoxinA for Refractory Idiopathic Detrusor Overactivity

Manecksha, Rustom P.; Cullen, Ivor M.; Ahmad, Sarfraz; McNeill, Graeme; Flynn, Robert J.; McDermott, Thomas E.; Grainger, Ronald G.; Thornhill, John

doi:10.1016/j.eururo.2011.10.043

Cited by 78 publications

(77 citation statements)

References 17 publications

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“…We also noticed our results similar to the preview studies [6][7][8][9][10][11][12]. One study found that not one of their 24 adults with OAB refractory to anticholinergic treatment who received trigoneinjection of BTX-A developed VUR during at 6-month follow-up [6].…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury

Zhuocheng¹,

Chen²,

Xh³

et al. 2018

AJMCR

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Section: Discussionsupporting

confidence: 78%

“…In the past ten years, intradetrusor injection of BTX-A was performed while avoiding the trigone to prevent VUR. To our knowledge, several studies reported satisfactory clinical results about combined detrusor-trigone BTX-A injections [6][7][8][9][10][11][12]. However, most of these studies were small and single-center experience.…”

Section: Introductionmentioning

confidence: 89%

Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury

Zhuocheng¹,

Chen²,

Xh³

et al. 2018

AJMCR

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“…The main characteristics of the 12 trials included in the meta-analysis are given in table 1. Except for one trial using abobotulinumtoxinA [17], all used onabotulinumtoxinA.…”

Section: Resultsmentioning

confidence: 99%

Botulinum Toxin-A Injections for Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis

Yu¹,

Wang²,

Liu³

et al. 2013

Urol Int

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Objective: To review the current evidence on the efficacy and safety of botulinum toxin-A in the management of idiopathic overactive bladder (OAB). Methods: A systematic search of PubMed, Embase and the Cochrane Central Search Library was performed. All randomized controlled trials comparing botulinum toxin-A with placebo, different doses and injection techniques, in patients with idiopathic OAB was included. The analyzed outcomes were quantification of symptoms, urodynamic outcomes, quality of life and adverse events. Result: A total of 1,020 participants from 12 randomized controlled trials were included. Botulinum toxin-A was associated with less urinary frequency, less incontinence episodes, improvement in quality of life, higher post-void residual-related catheterization and higher urinary tract infection. Doses of 100-300 U were not consistently differentiated from each other in voiding diary, quality of life and urge urinary incontinence. No statistically significant difference was seen between bladder body and bladder base, bladder body and bladder body plus trigone in urinary retention and urinary tract infection. Conclusion: Botulinum toxin-A is associated with significant improvement in OAB symptoms in patients with idiopathic OAB. However, there is a higher incidence of postoperative urinary retention and urinary infection compared to placebo. Low-dose botulinum toxin-A seems to be the optimum dose that appropriately balances the benefits with adverse events. Trigone inclusion seems as safe and effective as trigone-sparing injection.

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“…Mesane tavan›na intraperitoneal perforasyon ve barsak yaralanmas› riski nedeniyle, trigona vezikoüreteral reflü riski nedeniyle enjeksiyon yap›lmas› önerilmemektedir (14) . Nörojenik nedene ba¤l› olmayan detrüsör afl›r› aktivitesinde veya a¤r› J Turk Soc Obstet Gynecol 2013; 10: 9-15 veya duyu komponentlerinin bask›n oldu¤u hastalarda trigona da enjeksiyon önerilmifl ve iyi sonuçlar al›nm›flt›r (15).…”

Section: Botul‹nyum Toks‹n‹ Enjeks‹yonuunclassified

Botulinum toxin and neuromodulation for overactive bladder treatment

Akman¹

2013

J Turk Soc Obstet Gynecol

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Prospective Randomised Controlled Trial Comparing Trigone-Sparing versus Trigone-Including Intradetrusor Injection of AbobotulinumtoxinA for Refractory Idiopathic Detrusor Overactivity

Cited by 78 publications

References 17 publications

Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury

Video-urodynamic Improvement of Trigonal BTX-A Injection for Patients with Poor Bladder Compliance Secondary to Spinal Cord Injury

Botulinum Toxin-A Injections for Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis

Botulinum toxin and neuromodulation for overactive bladder treatment

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