Prospective pilot evaluation of a new needle prototype for endoscopic ultrasonography-guided fine-needle aspiration: comparison of cytology and histology yield

Papanikolaou, Ioannis S.; Adler, Andreas; Wegener, K; Al-Abadi, H.; Dürr, Angelika; Koch, Martin; Pohl, Heiko; Abou-Rebyeh, H.; Veltzke‐Schlieker, Wilfried; Wiedenmann, Bertram; Rösch, Thomas

doi:10.1097/meg.0b013e3282f2a5cf

Cited by 17 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…New techniques have been developed to improve the diagnosis of pancreatic masses, such as elastography, contrast-enhanced endoscopic ultrasound (CEUS), and endomicroscopy, and their combination with biopsy techniques has attracted interest. The most recent guideline on contrast-enhanced ultrasound states that the depiction of liquid or necrotic areas inside the pancreatic mass prior to any US-guided biopsy might help to better identify the target [11] and the combination of these two methods in a pilot study has yet to be published.…”

Section: Introductionmentioning

confidence: 99%

Harmonic Contrast-Enhanced Endoscopic Ultrasonography for the Guidance of Fine-Needle Aspiration in Solid Pancreatic Masses

et al. 2015

View full text Add to dashboard Cite

The global accuracy of fine-needle aspiration guided by endoscopic ultrasound (EUS-FNA) for pancreatic adenocarcinoma is about 85 %. The use of contrast agents during EUS to highlight vessels and the necrotic parts of pancreatic masses may improve biopsy guidance. Our aim was to assess whether the guidance of FNA by harmonic contrast-enhanced endoscopic ultrasound (CH-EUS) would increase diagnostic accuracy relative to conventional EUS-FNA in the same pancreatic masses. In a prospective study, EUS-FNA was performed in patients with pancreatic masses on CT scan, followed by harmonic CH-EUS using SonoVue. A second cluster of CH-EUS-FNA was performed on contrast-enhanced images. The final diagnosis was based on the results of EUS-FNA and surgery, or the findings after 12 months' follow-up. The final diagnosis was adenocarcinoma (n = 35), chronic pancreatitis (n = 10), or other (n = 6). The diagnostic accuracy based on core histology was 78.4 % for EUS-FNA and 86.5 % for CH-EUS-FNA (p = 0.35). The accuracy increased to 94 % when the two methods' results were combined. The two false-negative EUS-FNA cases were correctly appreciated by CH-EUS. Neither core histology size nor the presence of necrosis was significant for the true-positive diagnosis of malignancy. CH-EUS-FNA had an insignificant incremental effect on diagnostic accuracy compared with conventional EUS-FNA in our small group. The presence of necrosis did not influence the results of CEUS-FNA. Qualitative assessment of the contrast uptake within the lesion was useful in false-negative EUS-FNA cases.

show abstract

Section: Introductionmentioning

confidence: 99%

Harmonic Contrast-Enhanced Endoscopic Ultrasonography for the Guidance of Fine-Needle Aspiration in Solid Pancreatic Masses

et al. 2015

View full text Add to dashboard Cite

show abstract

“…EUS-FNA generally provides adequate material for pathologic assessment. [222324] According to a recent meta-analysis of pooled data, diagnostic sensitivity and specificity were 85% and 98%, respectively. [25]…”

Section: Clinical Indicationsmentioning

confidence: 99%

Clinical use of endoscopic ultrasound-guided fine-needle aspiration: Guidelines and recommendations from Chinese Society of Digestive Endoscopy

et al. 2017

View full text Add to dashboard Cite

“…For isolation sharp instruments like needle tips or scalpels can be used. If the needle load is split for cytopathological and histopathological examination, gross visual examination is reasonably accurate [285,521,641]. Tissue fragments appear white or discolored within the red cylinder of coagulated blood [332].…”

Section: Histopathology: Cell Block and Core Tissue Preparationmentioning

confidence: 99%

“…There are two reasonable strategies to achieve high diagnostic accuracy in EUS-guided sampling, without the attendance of a cytopathologist: combining cytopathological and histopathological evaluation [94,148,291,345,350,521,641,645,646], or relying on core tissue or CB material for histopathological assessment [95,97,216,332,361,369,503,517,524,639,640,647,648]. 55.8 % of the participants of a European EUS workshop described routine collection of material for histopathological analysis.…”

Section: A Complementary Approach: Combining Cytopathological and Hismentioning

confidence: 99%

EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part IV – EUS-guided Interventions: General aspects and EUS-guided sampling (Long Version)

et al. 2015

View full text Add to dashboard Cite

The fourth part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound describes general aspects of endoscopic ultrasound-guided diagnostic and therapeutic interventions and assesses the evidence for endoscopic ultrasound-guided sampling. Endoscopic ultrasound combines the most advanced high-resolution ultrasound imaging of lesions within the wall and in the vicinity of the gastrointestinal tract and safe and effective fine needle based tissue acquisition from these lesions. The guideline addresses the indications, contraindications, techniques, adverse events, training and clinical impact of EUS-guided sampling. Advantages and drawbacks are weighed in comparison with image-guided percutaneous biopsy. Based on the most current evidence, clinical practice recommendations are given for crucial preconditions and steps of EUS-guided sampling as well as for safe performance. Additionally, the guideline deals with the principles and reliability of cytopathological reporting in endoscopic ultrasound-guided sampling (long version).

show abstract

Prospective pilot evaluation of a new needle prototype for endoscopic ultrasonography-guided fine-needle aspiration: comparison of cytology and histology yield

Abstract: The new needle achieves sensitivities similar to those previously reported with no significant differences in sensitivity between cytology and histology. More effective tissue acquisition methods must be sought to improve overall results.

Cited by 17 publications

References 29 publications

Harmonic Contrast-Enhanced Endoscopic Ultrasonography for the Guidance of Fine-Needle Aspiration in Solid Pancreatic Masses

Harmonic Contrast-Enhanced Endoscopic Ultrasonography for the Guidance of Fine-Needle Aspiration in Solid Pancreatic Masses

Clinical use of endoscopic ultrasound-guided fine-needle aspiration: Guidelines and recommendations from Chinese Society of Digestive Endoscopy

EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part IV – EUS-guided Interventions: General aspects and EUS-guided sampling (Long Version)

Contact Info

Product

Resources

About