Prospective, Open Trial of Adjunctive Triple Chronotherapy for the Acute Treatment of Depression in Adolescent Inpatients

Hurd, Diane; Herrera, Mariela; Brant, Jeannine M.; Coombs, Nicholas; Arzubi, Eric

doi:10.1089/cap.2018.0063

Cited by 10 publications

(15 citation statements)

References 31 publications

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“…For this latter combination, a phase advance of the sleep–wake cycle and of the rest–activity rhythms is a correlate of antidepressant response to SD (Benedetti, Dallaspezia, Fulgosi, et al., ). The efficacy of the triple combination of SD, LT and sleep phase advance has been tested in multiple clinical settings and ethnic groups, with consistently replicated antidepressant effects and similar effect sizes (Benedetti, Barbini, et al., ; Berger et al., ; Echizenya, Suda, Takeshima, Inomata, & Shimizu, ; Gottlieb & Terman, ; Hurd, Herrera, Brant, Coombs, & Arzubi, ; Sahlem et al., ; Voderholzer et al., ; Wu et al., ).…”

Section: Where Are We Today?mentioning

confidence: 95%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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Mood disorders are often characterised by alterations in circadian rhythms, sleep disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise zeitgebers for circadian rhythms such as light to improve mood and stabilise sleep, and manipulations of sleep timing and duration as rapid antidepressant modalities. Although sleep deprivation (“wake therapy”) can act within hours, and its mood‐elevating effects be maintained by regular morning light administration/medication/earlier sleep, it has not entered the regular guidelines for treating affective disorders as a first‐line treatment. The hindrances to using chronotherapeutics may lie in their lack of patentability, few sponsors to carry out large multi‐centre trials, non‐reimbursement by medical insurance and their perceived difficulty or exotic “alternative” nature. Future use can be promoted by new technology (single‐sample phase measurements, phone apps, movement and sleep trackers) that provides ambulatory documentation over long periods and feedback to therapist and patient. Light combinations with cognitive behavioural therapy and sleep hygiene practice may speed up and also maintain response. The urgent need for new antidepressants should hopefully lead to reconsideration and implementation of these non‐pharmacological methods, as well as further clinical trials. We review the putative neurochemical mechanisms underlying the antidepressant effect of sleep deprivation and light therapy, and current knowledge linking clocks and sleep with affective disorders: neurotransmitter switching, stress and cortico‐limbic reactivity, clock genes, cortical neuroplasticity, connectomics and neuroinflammation. Despite the complexity of multi‐system mechanisms, more insight will lead to fine tuning and better application of circadian and sleep‐related treatments of depression.

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Section: Where Are We Today?mentioning

confidence: 95%

Perspectives in affective disorders: Clocks and sleep

Wirz‐Justice

Benedetti

2019

Eur J of Neuroscience

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“…In addition, patients under 18 were not included in the meta-analysis. However, despite being very few in number, two studies in adolescents have shown moderate to strong effects of chronotherapy in young people with major depression, including one RCT (Gest et al, 2016) and a recent case series (Hurd, Herrera, Brant, Coombs, & Arzubi, 2019).…”

Section: Limitations and Recommendationsmentioning

confidence: 99%

Chronotherapy for the rapid treatment of depression: A meta-analysis

Humpston

Benedetti

Serfaty

et al. 2020

Journal of Affective Disorders

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…Furthermore, subjects with extreme chronotypes are at higher risk to develop psychiatric disorders 16 . Interestingly, patients suffering from mood or anxiety disorders profit from chronotherapeutic interventions, 17,18 demonstrating that therapy approaches normalizing or strengthening circadian rhythms improve symptoms of mental disorders. In addition to human data, animal models were used to support the link between circadian rhythms and psychiatric endophenotypes.…”

Section: Introductionmentioning

confidence: 99%

An in‐depth neurobehavioral characterization shows anxiety‐like traits, impaired habituation behavior, and restlessness in male Cryptochrome‐deficient mice

Hühne

Volkmann

Stephan

et al. 2020

Genes Brain and Behavior

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Many psychiatric disorders, for example, anxiety, are accompanied by disturbances of circadian rhythms, including disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine function. Conversely, alternations of circadian rhythms are a risk factor for the development of psychiatric disorders. This assumption is supported by animals with clock gene mutations which often display behaviors that resemble human psychiatric disorders. In this study, we performed an in‐depth behavioral analysis with male mice lacking the central clock genes Cryptochrome 1 and 2 (Cry1/2−/−), which are thus unable to express endogenous circadian rhythms. With wild‐type and Cry1/2−/− mice, we performed an extensive behavioral analysis to study their cognitive abilities, social behavior, and their expression of depression‐like and anxiety‐like behavior. While Cry1/2−/− mice showed only mild abnormalities at cognitive and social behavioral levels, they were consistently more anxious than wildtype mice. Anxiety‐like behavior was particularly evident in reduced mobility in new environments, altered ability to habituate, compensatory behavior, and consistent restless behavior across many behavioral tests. In line with their anxiety‐like behavioral phenotype, Cry1/2−/− mice have higher c‐Fos activity in the amygdala after exposure to an anxiogenic stressor than wild‐type mice. In our study, we identified Cry1/2−/− mice as animals that qualify as a translational mouse model for anxiety disorder in humans because of its consistent behavior of restlessness, increased immobility, and dysfunctional habituation in new environments.

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Prospective, Open Trial of Adjunctive Triple Chronotherapy for the Acute Treatment of Depression in Adolescent Inpatients

Cited by 10 publications

References 31 publications

Perspectives in affective disorders: Clocks and sleep

Perspectives in affective disorders: Clocks and sleep

Chronotherapy for the rapid treatment of depression: A meta-analysis

An in‐depth neurobehavioral characterization shows anxiety‐like traits, impaired habituation behavior, and restlessness in male Cryptochrome‐deficient mice

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