Prospective open controlled study of 7% ectoine cream in complex treatment of persistent skin lesions in children with atopic dermatitis

Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review

“…Six studies were assessed, of which three were designed as prospective, open label studies [48][49][50], one as a prospective, open label study with control pairs [51], one as a randomized, nonblinded study [52], and one as randomized, intraindividual double-blinded study [35]. Certainty of evidence was graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework and ranged from very low (one study) to moderate certainty (three studies) (Table 1).…”

“…Certainty of evidence was graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework and ranged from very low (one study) to moderate certainty (three studies) (Table 1). The studies predominately included patients with atopic dermatitis [35,[48][49][50][51], while one study evaluated the prevention and management of retinoid dermatitis after pharmacological acne treatment [52]. The study duration (including follow-up) varied from 2 to 4 weeks for atopic dermatitis and 6 months for retinoid dermatitis.…”

“…Sample sizes ranged from 30 [49] to 242 [48], resulting in 525 recruited patients. Studies were performed on various continents and in several countries including Asia (Hong Kong) [49] and Europe (Germany, Poland, Russia) [35,48,[50][51][52].…”

“…The applied formulations contained between 5.5% [48] and 7% ectoine [35,[49][50][51][52]. Creams or emollients were used in all studies including the brand products Dermaveel, Perfectoin, and EHK02-01 creams (all by bitop AG, Witten, Germany).…”

“…Evaluated administration regimens included daily or twice daily application of the ectoine-containing formulation. The application in four studies was combined with other treatment regimens [48][49][50][51] including histamine antagonists [48,49], topical corticosteroids [48][49][50][51], and calcineurin inhibitor [48,51]. For the prevention and management of retinoid dermatitis, the ectoine-containing formulation was combined with standard isotretinoin therapy [52].…”