Prospective observational study on cholelithiasis in patients with carcinoma gall bladder in a tertiary referral hospital of Eastern India

Bhattacharjee, Prosanta Kumar; Nanda, Durgaprasad

doi:10.4103/jcrt.jcrt_939_17

Cited by 10 publications

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“…4 th decade was the commonest age group in the present study; which is similar in the studies by Gupta K et al [20] and Islam Mj et al [21]. The age ranged from 25 years to 65 years in malignant gallbladder cases; which is comparable to Shah B et al [22], Bhattacharjee K P et al [23]. In the present study; the upper limit of age is lower than most of the other studies like Dutta U…”

Section: Discussionsupporting

confidence: 90%

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Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Bora,

Saikia

2023

Asian Pac J Cancer Care

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Introduction: Cholecystectomy specimens show wide clinicopathological spectrum varying from common non neoplastic diseases to rare neoplastic lesions and histopathological examination the gold standard for final diagnosis. Gall Bladder Cancers (GBCs) are rare and account for 0.5% to 1.09% of all gall bladder lesions. It is either clinically suspected or incidentally diagnosed following cholecystectomy. Methods: It was a Hospital based cross-sectional Study. All cases diagnosed clinically & radiologically and operated as cholecystitis were included in the study. Histopathological diagnosis of gallbladder lesions, age & sex distribution in different gallbladder pathology, association with gall stones, Pathological pT staging of malignant cases and CK7 & CK20 immunohistochemical findings in malignant cases were observed in this study. Results: A total 340 cases of gallbladder specimens were examined histopathologically and 12 cases of gallbladder carcinoma were diagnosed. The most common histopathological diagnosis was chronic cholecystitis (79.4%) followed by chronic cholecystitis with cholesterolosis (7.6%) and adenocarcinoma (3.5%). The most common age group for gallbladder lesions was 4th decade (26.2%). Age varies from 09 – 85 years with a mean age of 39.4 years. Overall females (83%) are more commonly affected than males (17%) with male: female ratio is 1:4.96. Gallstones were present in 89.1% among total cases, 83.3% in malignant cases. Incidentally detected gallbladder carcinoma was 1.17% and most common histopathological type was adenocarcinoma NOS with Pathological pT staging was pT1 & pT2 only i.e. early stage. CK7 positivity was found in 91.6% cases and CK20 was positive in 16.7% cases. Both CK7 & CK20 was positive in 16.7% and both CK7 & CK20 was negative in one case (8.33%). Conclusions: Although the most common gall bladder histopathology diagnosis is chronic cholecystitis, the possibility of any incidental malignancy needs to be ruled out by mandatory routine histopathological examination of all cholecystectomy specimens.

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Section: Discussionsupporting

confidence: 90%

“…• 01 et al [24], Harikleia K et al [25], Hussain N H et al [26], Geramizadeh B et al [27]etc. The mean age in malignant cases was 49.8 years; which is comparable to other studies like Dutta U et al [24], Hussain N H et al [26], Shah B et al [22], Bhattacharjee K P et al [23].…”

Section: Pathological Stagingsupporting

confidence: 86%

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Bora,

Saikia

2023

Asian Pac J Cancer Care

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“…In our study, we found 71% of the GBC of adenocarcinoma variety, corroborating with the other studies. 16,17 The strength of our study was we studied the staging as well as histopathological features of GSD and GBC patients. Our study has some inherent limitations like small sample size and geographically limited catchment area of the patients enrolled.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological profile of Gallbladder Cancer (GBC) and Gallstone disease GSD) among the patients admitted in tertiary care institute in Kolkata

Mohata¹,

Adhikary

Bari

et al. 2022

InaJGHE

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Background: Gallstone disease (GSD) is one of the most common surgical problems throughout the world. The rise in gallstone disease burden and its wide spectrum of non-specific presentation makes the disease more challenging. Gall bladder cancer (GBC) is a common cancer in the northern and North-eastern States of India. The six cancer registries of the Indian Council of Medical Research (ICMR) (1990-1996) show a 10 times lower incidence of GBC per 1 00 000 in South India compared with the North. The objective of present study was to assess the epidemiological and pathological profile of GSD and GBC patients of Eastern India visiting tertiary care hospital of Kolkata.Method: This cross-sectional observational study was conducted, over a period of 18 months, at a tertiary referral hospital of Kolkata. In this study, 66 gallstone disease patients and 24 gallbladder cancer patients who undergone surgery were included in the study after their written informed consent. Data on their demographic and pathological profile, type of gallstones, their number and staging and type gallbladder cancer were collected. Results: GSD GBC were found to afflict females, Male to female ratio was 1:2 1:3 for GSD and GBC respectively. We found that nearly half (45.4%) GSD patients were in the age group of 21-40 years and more than half (58.6%) GBC patients were in age group of 41-60 years. Majority of GSD patients had multiple stones (57.6%) and cholesterol stones were most common (59.1%). Out of 24 GBC patients, nearly one-third (33.3%) had stage II cancer and only 12.5% patients had stage IV cancer. More than one-fourth (29.2%) GBC patients had poorly differentiated carcinoma.Conclusion: The results of this study reaffirm that female gender is a strong predisposing factor for GSD and GBC and patients in their fourth decade, are more at risk. Large population based multicentric analytical study is necessary to strengthen this study findings.

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“…Cholelithiasis is present in 75-92% of gallbladder cancers. [16] In a routine histopathological examination of the gallbladder, chronic cholecystitis is detected in the rate of 89-96.3%. [7,8] In our study, chronic cholecystitis constituted 92.7% of pathological findings.…”

Section: Discussionmentioning

confidence: 99%

Incidental cancer in elderly versus younger patients underwent laparoscopic and open cholecystectomy: A retrospective analysis of 2389 patients

Uylaş¹

2020

Laparosc Endosc Surg Sci

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Introduction: Routine histopathological examination allows the detection of incidental gallbladder cancers. In the present study, we aimed to determine the rate of incidental gallbladder cancer and other pathology outcomes in young and elderly patients who underwent laparoscopic and open cholecystectomy. Materials and Methods:Patients who underwent laparoscopic and open cholecystectomy in the acute or elective period in our center were retrospectively analyzed. A total of 2389 patients were included in the study. The patients were divided into two groups, as the younger (<60 years old) and elderly (≥60 years old).Results: Of all patients, 476 (19.9%) were male and 1913 (80.1%) were female; the mean age was 46 years (range 17-90). There were 486 patients in the elderly group (18.7%). Chronic cholecystitis was detected in 2228 patients, acute cholecystitis in 141, Xanthogranulomatous cholecystitis in eight, gangrenous cholecystitis in six, and follicular cholecystitis and adenocarcinoma in three patients each. Chronic cholecystitis was more common in the young group, while acute cholecystitis was more common in the elderly group (p<0.05). Adenocarcinoma was detected in three patients (0.13%), all of whom were in the elderly group (p<0.05). Conclusion:Acute or chronic cholecystitis accompanied by a thickened gallbladder wall and a prolonged history of gallstones may be accompanied by malignancy, especially in elderly patients.

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Prospective observational study on cholelithiasis in patients with carcinoma gall bladder in a tertiary referral hospital of Eastern India

Cited by 10 publications

References 0 publications

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20

Clinical and pathological profile of Gallbladder Cancer (GBC) and Gallstone disease GSD) among the patients admitted in tertiary care institute in Kolkata

Incidental cancer in elderly versus younger patients underwent laparoscopic and open cholecystectomy: A retrospective analysis of 2389 patients

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