Prospective, noncomparative open study from Kuwait of the role of intravenous immunoglobulin in the treatment of toxic epidermal necrolysis

Abstract

Our experience of treating 12 patients with TEN using IVIG, in Kuwait, confirms that it is a safe and effective treatment for these patients.

Toxic epidermal necrolysis: Review of pathogenesis and management

“…Numerous studies describe favorable outcomes following the use of IVIg. [63][64][65][66][67][68][69] Brown et al 70 and Bachot et al, 71 in contrast, reported poorer outcomes following treatment with IVIg. Several limitations of these two studies have been put forward.…”

Toxic epidermal necrolysis

“…197 One-hundred percent survival was observed in a prospective study of 12 TEN patients from Kuwait treated with IVIG. 198 In a report of nine TEN patients treated with IVIG and pulse methylprednisolone, eight survived. Although the methylprednisolone is a confounding factor, it was nonetheless concluded that IVIG is a ''safe and valid'' therapy for TEN.…”

Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis = الغلوبيولين المناعي الوريدي في علاج إنحلال البشرة السمي الناتج عن الفانكوميسين

“…Our experience of using IVIG in the treatment of TEN with a favourable outcome could be useful to those in other Arabian Gulf countries, whose citizens' genetic and environmental circumstances are similar to those of our patient. 15 …”