Prospective neurometric studies during the beginning of carbamazepine and phenytoin therapy

Danner, Rolf; Lang, Heikki; Yale, Coralee

doi:10.1111/j.1600-0404.1984.tb07803.x

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…After collecting NCV information along with age, sex and type of drug, data were analyzed by statistical methods in SPSS version 19. and peroneal nerves [3]. A study by Danner, et al found that carbamazepine as an anti-seizure drug more than phenytoin reduced the NCV which was similar to our study results [12]. According to the results of Freeman, et al research on the subject of polyneuropathy treatment, the mean of decrease in NCV for placebo was higher than that of topiramate.…”

Section: Methodssupporting

confidence: 90%

“…Danner, et al found that anticonvulsants reduce NCV but of them carbamazepine reduces NCV more than phenytoin [12]. Swift, et al in their studies showed that there is no relation between the level of phenobarbital or phenytoin in blood and the duration of their use and the abnormality of electrical findings as well as environmental neuropathy [14].…”

Section: Discussionmentioning

confidence: 99%

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2019

Int J Neurol Neurother

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Anticonvulsants such as phenytoin, phenobarbital, topiramate, carbamazepine and valproate due to their beneficial effects and economic benefits in compare to new drugs are used more but these drugs are not harmless and sometimes had dangerous, safe and reversible side effects. Reduction of the nervous conduction velocity (NCV) is the common side effect of these drugs and it is of clinically importance if it is severe especially in treated children. Therefore, it is necessary to evaluate and compare the effect of each drug on NCV. The aim of this study was to investigate the effects of antiepileptic drugs on NCV. In this quasi-experimental study, 125 children with seizure were randomly selected and divided into six equal size groups which received phenytoin, phenobarbital, topiramate, valproate, carbamazepine and one group as control which no received anti-epileptic drug. Sensory and motor neural conduction velocity were measured and recorded for all children in groups. Collected data were analyzed by statistical methods in SPSS version 19. All of anticonvulsants were reduced the NCV in children but among all drugs, phenobarbital and phenytoin had the least and most impact on the NCV. The changes in NCV were not related to the age and gender of children. Results showed that the anticonvulsants had similar impact on NCV in generally but future studies are recommended by considering the other effective variables on response to drug.

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Section: Methodssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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2019

Int J Neurol Neurother

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“…Of 14 visually analysed CBZ EEG reports, one volunteer (Holder et al, 1975) and two patients (Partanen et al, 1985;Duncan et al, 1989) studies showed an increase in slow activity and decrease in the frequency of the dominant occipital rhythm. A further seven patient studies demonstrated an increase in background slow activity (Pryse-Phillips and Jeavons, 1970;Rodin et al, 1974Rodin et al, , 1976Monaco et al, 1978;Wilkus et al, 1978;Kischimoto et al, 1985;Misurec et al, 1985), while four failed to show any change (Monaco et al, 1979;Trimble, 1982, 1983;Danner et al, 1984). Three computer-based studies showed an increase in the amplitude of theta and delta activity with a decrease in the alpha and beta frequencies (Frost et al, 1989), slowing of the occipital rhythm without amplitude changes (Mervaala et al, 1989), and an absence of any significant effect (Drake et al, 1988).…”

Section: Discussionmentioning

confidence: 98%

Effect of Acute Doses of Controlled‐Release Carbamazepine on Clinical, Psychomotor, Electrophysiological, and Cognitive Parameters of Brain Function

et al. 1992

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The neurotoxic effect of acute doses of carbamazepine controlled-release (CBZ-CR) divitabs (800, 1,200, and 1,600 mg) was assessed on clinical, psychomotor, electrophysiological, and cognitive parameters of brain function in 10 healthy volunteers in a double-blind, randomised, placebo-controlled, phase I study. Significant changes compared to placebo were demonstrated for the clinical scales, ataxia (AT), convergence of the near-point (CNP), peak saccadic velocity (PSV), critical flicker fusion (CFF), spectral analysis of the EEG, and brainstem auditory evoked potential (BAEP) tests. Digit repetition, digit symbol substitution, Sternberg memory scanning time, Sternberg choice reaction time, saccadic latency, and saccadic accuracy showed important negative findings. Significant clinical tolerance to side effects developed within 20 to 33 h after CBZ-CR dosage during a period in which the mean CBZ blood levels remained virtually unchanged. CBZ-CR, 800, 1,200, and 1,600 mg yielded low, medium, and high therapeutic blood levels, respectively, for +10 to +33 h after dosage without the development of severe clinical side effects.

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“…The reports of AED neuropathy have sometimes been conflicting, however, as a few retrospective (Brumlik and Moretti, 1966) and prospective studies (Ludhorfet al, 1983;Danner et al, 1984;Bottacchi et al, 1988) showed no signs of impairment of the peripheral nerve in patients receiving PHT and CBZ. Most of the controversies might be explained by methodologic inconsistencies, such as the small numbers of cases, use of polytherapy, and variety of electrophysiologic testing methods.…”

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confidence: 99%

Antiepileptic Drugs and Peripheral Nerve Function: A Multicenter Screening Investigation of 141 Patients with Chronic Treatment

et al. 1993

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One hundred forty-one adult patients treated for no less than 6 months with standard daily doses of the commonest antiepileptic drugs (AEDs) were recruited in five Italian centers and submitted to intensive clinical and electrophysiologic investigation to assess the effects of AEDs on peripheral nerves. Eighty percent of the patients were receiving monotherapy. Carbamazepine (CBZ) was the most common AED (51 cases), followed by phenytoin (PHT) (46), phenobarbital (PB) (42), and valproate (VPA) (25). Fifty-three percent of the patients had one or more symptoms of polyneuropathy (paresthesias being the most common complaint). The neurologic examination was abnormal in 32%. Electrophysiologic findings in two or more separate nerves were abnormal in 77 patients (54.6%); of these, 27 (19.1%) had abnormal neurologic findings and 21 (14.9%) also had symptoms of polyneuropathy. Sensory functions were most frequently impaired. Sural nerve biopsy was performed in 4 patients receiving monotherapy with CBZ, PHT, PB, and VPA. Except in patients receiving VPA (in whom no morphologic abnormalities were detected), mild predominantly axonal damage with secondary myelin changes was noted. A correlation was noted between polyneuropathy, age of the patient and, to a lesser extent, receipt of two or more AEDs.

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Prospective neurometric studies during the beginning of carbamazepine and phenytoin therapy

Cited by 5 publications

References 17 publications

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Effect of Acute Doses of Controlled‐Release Carbamazepine on Clinical, Psychomotor, Electrophysiological, and Cognitive Parameters of Brain Function

Antiepileptic Drugs and Peripheral Nerve Function: A Multicenter Screening Investigation of 141 Patients with Chronic Treatment

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