Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial

Abstract

In women at elevated familial risk, quality-assured MRI screening shifts the distribution of screen-detected breast cancers toward the preinvasive stage. In women undergoing quality-assured MRI annually, neither mammography, nor annual or half-yearly ultrasound or CBE will add to the cancer yield achieved by MRI alone.

Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype

“…This reinforces the importance of MRI in the study of young patients, especially those with highrisk for breast cancer. Kuhl et al [14] showed that the sensitivity for detection of breast cancer in high-risk patients was 33%, 37% and 92%, respectively, for mammography, ultrasound and MRI. In the current study, MRI showed better performance than mammography and ultrasound in suggesting histologically confirmed multifocal and multicentric tumors.…”

“…This method has the highest sensitivity to assess the tumor extent and the detection of multifocal and multicentric disease. MRI was also able to indicate a greater number of associated findings, playing an important role in the locoregional staging of breast cancer and its treatment planning [14][15][16][17]. Sardanelli et al [15], showed that MRI was more sensitive (81%) compared to mammography (60%) in the detection of additional tumor foci in nonfatty breasts.…”

Changes in the Attitudes and Behavior of Relatives of Breast Cancer Patients Concerning Cancer Prevention and Screening

“…These carry a different potential in each individual and have a different risk load [Harold JB, et al, 2008]. It is reported that familial breast cancer occurs earlier than sporadic breast cancer; thus, screening tests should be administered starting from between the ages of 25 to 30 (Kuhl et al, 2010). Individuals with first-degree relatives diagnosed with breast cancer have a 5.5% risk of having breast cancer while this risk increases to 13.3% if there are two first-degree relatives with the disease (Collaborative Breast cancer is a phenomenon that results from both familial and environmental factors, and, as a result, it can potentially affect all members of a family.…”

“…Individuals with first-degree relatives diagnosed with breast cancer have a 5.5% risk of having breast cancer while this risk increases to 13.3% if there are two first-degree relatives with the disease (Collaborative Breast cancer is a phenomenon that results from both familial and environmental factors, and, as a result, it can potentially affect all members of a family. However, it is not yet clear whether there is a change in the attitudes and behaviors of family members toward cancer after one individual in the family has been diagnosed with breast cancer (Goss et al, 1998;Collaborative Group on Hormonal Factors in Breast Cancer, 2001;Calzone et al, 2005;Harold et al, 2008;Kuhl et al, 2010).…”

Breast Cancer Screening: Updated Recommendations of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Breast Disease Society, and Brazilian Federation of Gynecological and Obstetrical Associations

“…Another key factor is the continued investigation with a biopsy of the lesions detected only by magnetic resonance imaging or the support of a reference center to perform these procedures. 29,30 Therefore, magnetic resonance imaging is the ancillary screening method of choice for women at high genetic risk and ultrasound should only be used if magnetic resonance imaging cannot be performed for some reason.…”