Prospective memory impairment in long-term opiate users

Terrett, Gill; McLennan, Skye N.; Henry, Julie D.; Biernacki, Kathryn; Mercuri, Kimberly; Curran, H. Valerie; Rendell, Peter G.

doi:10.1007/s00213-014-3432-6

Cited by 35 publications

(25 citation statements)

References 48 publications

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“…Disturbances in the ability to form appropriate associative memories and perform adaptive associative learning tasks, has been identified as critical neuropsychopathological features in both schizophrenia (10, 11) and addiction (12, 13). In both cases, patients may be more likely to inappropriately assign distorted emotional significance to internal or external stimuli, leading to aberrant associative memory formation.…”

Section: Evidence For Dysregulated Endocannabinoid Signaling In Schizmentioning

confidence: 99%

The Role of Cannabinoid Transmission in Emotional Memory Formation: Implications for Addiction and Schizophrenia

et al. 2014

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Emerging evidence from both basic and clinical research demonstrates an important role for endocannabinoid (ECB) signaling in the processing of emotionally salient information, learning, and memory. Cannabinoid transmission within neural circuits involved in emotional processing has been shown to modulate the acquisition, recall, and extinction of emotionally salient memories and importantly, can strongly modulate the emotional salience of incoming sensory information. Two neural regions in particular, the medial prefrontal cortex (PFC) and the basolateral nucleus of the amygdala (BLA), play important roles in emotional regulation and contain high levels of cannabinoid receptors. Furthermore, both regions show profound abnormalities in neuropsychiatric disorders such as addiction and schizophrenia. Considerable evidence has demonstrated that cannabinoid transmission functionally interacts with dopamine (DA), a neurotransmitter system that is of exceptional importance for both addictive behaviors and the neuropsychopathology of disorders like schizophrenia. Research in our laboratory has focused on how cannabinoid transmission both within and extrinsic to the mesolimbic DA system, including the BLA → mPFC circuitry, can modulate both rewarding and aversive emotional information. In this review, we will summarize clinical and basic neuroscience research demonstrating the importance of cannabinoid signaling within this neural circuitry. In particular, evidence will be reviewed emphasizing the importance of cannabinoid signaling within the BLA → mPFC circuitry in the context of emotional salience processing, memory formation and memory-related plasticity. We propose that aberrant states of hyper or hypoactive ECB signaling within the amygdala-prefrontal cortical circuit may lead to dysregulation of mesocorticolimbic DA transmission controlling the processing of emotionally salient information. These disturbances may in turn lead to emotional processing, learning, and memory abnormalities related to various neuropsychiatric disorders, including addiction and schizophrenia-related psychoses.

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Section: Evidence For Dysregulated Endocannabinoid Signaling In Schizmentioning

confidence: 99%

The Role of Cannabinoid Transmission in Emotional Memory Formation: Implications for Addiction and Schizophrenia

et al. 2014

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“…Performance on our prospective memory training program was significantly and positively correlated with performance on the Virtual Week, which has consistently shown poorer performance in populations with a history of drug use relative to control populations (Griffiths et al, 2012; Henry et al, 2009; Rendell et al, 2007; Rendell et al, 2009; Terrett et al, 2014). We found significant correlations between performance on event-based tasks with our program and event-and time-based tasks on the Virtual Week, but not between time-based tasks on our training program and time-based tasks with the Virtual Week.…”

Section: Discussionmentioning

confidence: 84%

“…The Virtual Week is a validated behavioral measure of prospective memory (Rendell & Craik, 2000; Rendell & Henry, 2009) that has shown poorer performance in substance-using populations (Griffiths et al, 2012; Henry, Mazur, & Rendell, 2009; Rendell et al, 2007; Rendell et al, 2009; Terrett et al, 2014). We used the computerized, brief version of the Virtual Week, which includes one practice day and two virtual days 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Individuals with a history of substance use also show impairment in prospective memory. This is true across a wide range of substances and populations including opioids (Terrett et al, 2014), methamphetamine (Rendell, Mazur, & Henry, 2009), MDMA (3,4-methylenedioxy-methamphetamine; (Heffernan, Jarvis, Rodgers, Scholey, & Ling, 2001; Rendell, Gray, Henry, & Tolan, 2007; Rodgers et al, 2001), alcohol (Griffiths et al, 2012; Heffernan, Clark, Bartholomew, Ling, & Stephens, 2010; Heffernan, 2008; Heffernan et al, 2006), cannabis (Bartholomew, Holroyd, & Heffernan, 2010; McHale & Hunt, 2008; Montgomery, Seddon, Fisk, Murphy, & Jansari, 2012; Rodgers et al, 2001), and substance dependent individuals living with HIV (Martin et al, 2007). In substance-dependent HIV-seropositive individuals, prospective memory deficits predict self-reported risky sexual and injection practices (Martin et al, 2007).…”

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confidence: 99%

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Initial feasibility and validity of a prospective memory training program in a substance use treatment population.

Sweeney¹,

Rass²,

Johnson³

et al. 2016

Experimental and Clinical Psychopharmacology

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Individuals with substance use disorders have shown deficits in the ability to implement future intentions, called prospective memory. Deficits in prospective memory and working memory, a critical underlying component of prospective memory, likely contribute to substance use treatment failures. Thus, improvement of prospective memory and working memory in substance use patients is an innovative target for intervention. We sought to develop a feasible and valid prospective memory training program that incorporates working memory training and may serve as a useful adjunct to substance use disorder treatment. We administered a single session of the novel prospective memory and working memory training program to participants (n = 22; 13 male; 9 female) enrolled in outpatient substance use disorder treatment and correlated performance to existing measures of prospective memory and working memory. Generally accurate prospective memory performance in a single session suggests feasibility in a substance use treatment population. However, training difficulty should be increased to avoid ceiling effects across repeated sessions. Consistent with existing literature, we observed superior performance on event-based relative to time-based prospective memory tasks. Performance on the prospective memory and working memory training components correlated with validated assessments of prospective memory and working memory, respectively. Correlations between novel memory training program performance and established measures suggest that our training engages appropriate cognitive processes. Further, differential event- and time-based prospective memory task performance suggests internal validity of our training. These data support development of this intervention as an adjunctive therapy for substance use disorders.

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“…These include Alzheimer’s disease (Troyer and Murphy 2007), mild cognitive impairment (Blanco-Campal et al 2009), obsessive-compulsive disorder (Cuttler and Graf 2008), attention deficit hyperactivity disorder (Altgassen et al 2014), and various forms of substance abuse and exposure (Heffernan, Clark, et al 2010; Heffernan and O'Neill 2013; Heffernan, O’Neill, et al 2010; Heffernan et al 2012; Martin et al 2007; Terrett et al 2014; Weinborn et al 2013). …”

Section: Comparative Questions Based On Insights From Prospective mentioning

confidence: 99%

Prospective memory: A comparative perspective

Crystal

Wilson

2015

Behavioural Processes

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Prospective memory consists of forming a representation of a future action, temporarily storing that representation in memory, and retrieving it at a future time point. Here we review the recent development of animal models of prospective memory. We review experiments using rats that focus on the development of time-based and event-based prospective memory. Next, we review a number of prospective-memory approaches that have been used with a variety of non-human primates. Finally, we review selected approaches from the human literature on prospective memory to identify targets for development of animal models of prospective memory.

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Prospective memory impairment in long-term opiate users

Cited by 35 publications

References 48 publications

The Role of Cannabinoid Transmission in Emotional Memory Formation: Implications for Addiction and Schizophrenia

The Role of Cannabinoid Transmission in Emotional Memory Formation: Implications for Addiction and Schizophrenia

Initial feasibility and validity of a prospective memory training program in a substance use treatment population.

Prospective memory: A comparative perspective

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