Prospective memory impairment in idiopathic REM sleep behavior disorder

Bezdíček, Ondřej; Nikolai, Tomáš; Nepožitek, Jiří; Peřinová, Pavla; Kemlink, David; Dušek, Pavel; Příhodová, Iva; Dostálová, Simona; Ibarburu, Veronika; Trnka, Jiří; Kupka, Karel; Mecková, Zuzana; Keller, Jiří; Vymazal, Josef; Růžička, Evžen; Šonka, Karel; Dušek, Petr

doi:10.1080/13854046.2017.1394493

Cited by 18 publications

(8 citation statements)

References 86 publications

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“…NREM and REM processes may interact dynamically to help preserve a range of cognitive processes [74]. In the current work, REM sleep duration was significantly associated with prospective memory consolidation in young adults and middle-to-older aged adults, which adds to a developing literature on prospective memory being impacted by sleep disruption [9][10][11][12][75][76][77] and by clinical sleep disorders [78][79][80]. The current findings fit the theoretical view that prospective memory consolidation occurs via reactivation processes followed by cue-intention association processes, but alternative accounts should also be tested.…”

Section: Discussionmentioning

confidence: 62%

Rapid eye movement sleep mediates age-related decline in prospective memory consolidation

Scullin

Gao

Fillmore

et al. 2019

Sleep

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Study Objectives: Prospective memory, or remembering to execute future intentions, accounts for half of everyday forgetting in older adults. Sleep intervals benefit prospective memory consolidation in young adults, but it is unknown whether age-related changes in slow wave activity, sleep spindles, and/or rapid eye movement (REM) sleep mediate hypothesized effects of aging on prospective memory consolidation. Methods: After an adaptation night, 76 adults aged 18-84 completed two experimental nights of in-laboratory polysomnography recording. In the evening, participants encoded and practiced a prospective memory task and were tested the next morning. On a counterbalanced night, they encoded and practiced a control task, and were tested the following morning. Results: Increasing age predicted worse prospective memory consolidation (r = −.34), even when controlling for encoding, speed, and control-task performance (all ps < .05). Frontal delta power, slow oscillations, and spindle density were not related to prospective memory consolidation. REM sleep duration, however, explained significant variance in prospective memory consolidation when controlling for age (∆R 2 = .10). Bootstrapping mediation showed that less REM sleep significantly mediated the aging effect on prospective memory consolidation [b = −.0016, SE = 0.0009 (95% confidence interval [CI] = −0.0042 to −0.0004)]. REM sleep continued to mediate 24.29% of the total effect of age on prospective memory after controlling for numerous demographic, cognitive, mental health, and sleep variables. Conclusion: Age-related variance in REM sleep is informative to how prospective memory consolidation changes with increasing age. Future work should consider how both REM sleep and slow wave activity contribute, perhaps in a sequential or dynamic manner, to preserving cognitive functioning with increasing age.

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Section: Discussionmentioning

confidence: 62%

Rapid eye movement sleep mediates age-related decline in prospective memory consolidation

Scullin

Gao

Fillmore

et al. 2019

Sleep

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“…Significant differences in cognitive functioning (memory, executive functions) between iRBD and healthy controls have been found ( 83 – 86 ). The frequency of mild cognitive impairment (MCI) was estimated to be 33–50% in iRBD patients and 63–73% in PD patients with RBD, respectively ( 87 ).…”

Section: Diagnostic Accuracy Of Clinical Measures For Predicting Convmentioning

confidence: 99%

“…In iRBD selective attention, executive functions and episodic verbal and non-verbal memory are the most affected ( 83 – 85 , 92 ). Positive correlation between time-based prospective memory performance and reduced striatal dopamine transport uptake on DaT scan on the more affected side has been found ( 86 ), indicating that impaired prospective memory may also be a marker for neurodegeneration associated with dopamine depletion syndromes. However, the presence of visuospatial and visuoconstructional deficits has also been reported in some studies ( 92 – 94 ), especially in those iRBD subgroups that later convert to PD dementia or DLB.…”

Section: Diagnostic Accuracy Of Clinical Measures For Predicting Convmentioning

confidence: 99%

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

et al. 2018

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Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors. Definite diagnosis of RBD is based on history and polysomnography, both of which are less accessible due to the lack of trained specialists and high cost. While RBD may be associated with disorders like narcolepsy, focal brain lesions, and encephalitis, idiopathic RBD (iRBD) may convert to Parkinson’s disease (PD) and other synucleinopathies in more than 80% of patients and it is to date the most specific clinical prodromal marker of PD. Identification of individuals at high risk for development of PD is becoming one of the most important topics for current PD-related research as well as for future treatment trials targeting prodromal PD. Furthermore, concomitant clinical symptoms, such as subtle motor impairment, hyposmia, autonomic dysfunction, or cognitive difficulties, in subjects with iRBD may herald its phenoconversion to clinically manifest parkinsonism. The assessment of these motor and non-motor symptoms in iRBD may increase the sensitivity and specificity in identifying prodromal PD subjects. This review evaluates the diagnostic accuracy of individual rating scales and validated single items for screening of RBD and the role and accuracy of available clinical, electrophysiological, imaging, and tissue biomarkers in predicting the phenoconversion from iRBD to clinically manifest synucleinopathies.

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“…[ 58 59 ] Recent studies have shown that event-related memory and prospective memory were impaired in patients with iRBD. [ 60 ] A study involving 21 iRBD patients, 26 PD patients, and 26 healthy controls found that the accuracy of visual short-term memory was significantly reduced in patients with iRBD and PD, suggesting that there was a similarity in working memory impairments between them. [ 55 ] Even some studies found that iRBD patients were more likely to have impaired word memory and visual space function regardless of whether they had PD,[ 61 ] and iRBD without dementia also had a progressive decline in memory and executive functions.…”

Section: Iagnosis Of R Apid Ementioning

confidence: 99%

Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases

Wang

Liu

et al. 2018

Chinese Medical Journal

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Objective:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions.Data Sources:Using the combined keywords: “RBD”, “neurodegenerative disease”, “Parkinson disease”, and “magnetic resonance imaging”, the PubMed/MEDLINE literature search was conducted up to January 1, 2018.Study Selection:A total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full.Results:Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings.Conclusions:More longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for more treatment trials to determine the effectiveness of interventions of RBD on preventing the conversion to neurodegenerative diseases.

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Prospective memory impairment in idiopathic REM sleep behavior disorder

Cited by 18 publications

References 86 publications

Rapid eye movement sleep mediates age-related decline in prospective memory consolidation

Rapid eye movement sleep mediates age-related decline in prospective memory consolidation

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases

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