Background: Peri-implantitis is defined as a biofilm-associated pathological condition that features an inflammatory lesion in the peri-implant mucosa and a loss of the implant supportive bone. At the time being, there are no data which may allow for a more in-depth evaluation of the dynamics of hard and soft tissue remodeling and maturation following surgical therapy of peri-implantitis. Aim/Hypothesis: To assess volumetric tissue changes at peri-implantitis sites following combined surgical therapy of peri-implantitis over a 6-month follow-up period. Materials and Methods: Twenty patients (n = 28 implants) diagnosed with peri-implantitis underwent access flap surgery, implantoplasty at supracrestally or bucally exposed implant surfaces and augmentation at intrabony components using a natural bone mineral and application of a native collagen membrane during clinical routine treatments. The peri-implant region of interest (ROI) was intraorally scanned pre-operatively (S0), and after 1 (S1) and 6 (S2) months following surgical therapy. Digital files were converted to standard tessellation language (STL) format for superimposition and assessment of peri-implant volumetric variations between time points. The change in thickness was assessed at a standardized ROI, subdivided into three equidistant sections (i.e. marginal, medial and apical). Peri-implant soft tissue contour area (STCA) (mm 2) and its corresponding contraction rates (%) were also assessed. Results: Peri-implant tissues revealed a mean thickness change (loss) of −0.11 and −0.28 mm at 1 and 6 months. S0 to S1 volumetric variations pointed to a thickness change of −0.46, 0.08, and 0.4 mm at marginal, medial and apical regions, respectively. S0 to S2 analysis exhibited corresponding thickness changes of −0.61, −0.25 and −0.09 mm, respectively. The thickness differences between the areas were statistically significant at both time periods. The mean peri-implant STCA totaled to 189.2, 175 and 158.9 mm 2 at S0, S1 and S2, showing a significant STCA contraction rate of 7.9% from S0 to S1 and of 18.5% from S0 to S2. Linear regression analysis revealed a significant correlation between the pre-operative width of keratinized mucosa (KM) and STCA contraction rate. Conclusions and Clinical Implications: The present volumetric analysis suggests that peri-implant tissues undergo considerable volumetric changes after combined surgical therapy. The tissue contraction, however, was influenced by the width of KM. Clinical implications: The dimensional changes following combined surgical therapy of peri-implantitis are commonly associated with an esthetic compromise at respective implant sites. These events may however be affected by the preoperative width of keratinized tissues at implant sites.