PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to assess residual tumor in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery

Abstract

Our results show that grayscale and color Doppler ultrasound have a low level of diagnostic performance in detecting residual disease after neoadjuvant chemoradiation in patients with locally advanced cervical cancer. The best performance was achieved in detection of macroscopic (≥ 6 mm) residual disease. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Human papillomavirus independent status on pathologic response and outcomes in locally advanced cervical cancer managed with chemoradiotherapy followed by surgery

“…A total of 254 locally advanced cervical cancer patients (FIGO 2018 stages IB2–IVA)14 treated with chemoradiotherapy followed by radical surgery, between January 2004 and March 2018, were included. Data for these patients were retrieved from our four phase II clinical studies15–18 based on preoperative chemoradiotherapy followed by surgery; this approach, which replaces intracavitary vaginal brachytherapy with surgery after chemoradiotherapy, has been proposed to improve local disease control and reduce radiation dose and potential toxicity 13. Two meta-analyses published by Shim et al19 and Lu et al20 reported that completion hysterectomy after chemoradiotherapy versus exclusive chemoradiotherapy did not improve survival in locally advanced cervical cancer patients, but seemed to reduce the risk of local recurrence.…”

“…Pelvic ultrasound was used, but not as staging. Preoperative chemoradiotherapy was administered as whole pelvic irradiation (total dose 39.6–50.4 Gy) with cisplatin-based regimens 15–18…”

PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery

“…For each session, the planned time interval between the three imaging modalities did not exceed 1 week. In the present study, we considered ultrasound data only, obtained at baseline and after 2 weeks of treatment, while the ultrasound data from the final evaluation and the data for the other two diagnostic methods, MRI and PET/CT, will be presented in further papers, including only the best ultrasound variables identified by the present analysis.…”

A Pilot Study on Diagnostic Performance of Contrast-Enhanced Ultrasonography for Detection of Early Cervical Cancer

“…Research on 3D US and cervical cancer has focused as well on the possible predictive value for patients that are subject to NACT before surgery or primary RCT with negative results. FI was suggested as a predictive marker for NACT responders, (129) however, neither in the prospective PRICE study nor another smaller study were 3D vascular indices found useful to monitor response to NACT or RCT in patients with advanced disease (121,130).…”