Prospective hospital based study on persistent diarrhoea.

Dutta, P; Lahiri, M. N.; Sen, D.; Pal, Sandip

doi:10.1136/gut.32.7.787

Cited by 14 publications

(11 citation statements)

References 8 publications

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“…Shigella flexneri, Shigella boydii, Salmonella typhimurium, Enteroagrregative E. coli, Enteropathogenic E. coli, Aeromonus sp. and rotavirus, was observed which corroborates the findings of other studies in developing countries (25)(26)(27). The most likely explanation for the high isolation rate of enteropathogens in our study population is that the initial infection persisted even at the time of enrolment, reflecting dehydration and high purging rates of these cases.…”

Section: Discussionsupporting

confidence: 92%

Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

et al. 2000

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Section: Discussionsupporting

confidence: 92%

Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

et al. 2000

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“…Our study like many others confirm that pathogenic E. coli and Shigella dominate in developing countries, 68,72,77,108 compared with Salmonella, Shigella, and Campylobacter in industrialized countries. 109–111 These pathogens are transmitted through mainly fecal oral route, 112–115 and contaminated food or water.…”

Section: Discussionsupporting

confidence: 89%

“…Bacteria were the main pathogens identified by a majority of studies, and the high rates of diarrhoeagenic E. coli spp ., Shigella, Salmonella spp ., and Campylobacter spp ., is consistent with the prevailing risk factors, 9 , 11 , 106 , 107 and likely reflects the availability of bacteriological diagnostic techniques. Our study like many others confirm that pathogenic E. coli and Shigella dominate in developing countries, 68 , 72 , 77 , 108 compared with Salmonella, Shigella, and Campylobacter in industrialized countries. 109 – 111 These pathogens are transmitted through mainly fecal oral route, 112 – 115 and contaminated food or water.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of gastrointestinal pathogens in Sub-Saharan Africa: systematic review and meta-analysis

Fletcher-Lartey

Stark

Ellis

2011

J Public Health Africa

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A significant proportion of vulnerable people in sub-Saharan Africa (SSA) remain at risk for contracting diarrhoeal diseases due to the presence of many risk factors facilitating their transmission. A systematic review of published articles from the SSA region was done to determine the prevalence and types of diarrhoeal pathogens in circulation, based on a search of databases, including EBSCO host, PubMed, Scopus, Science Direct, Google scholar and Web of Science was done between September 2009 and December 2010. Data were summarized from 27 studies, with pooled data analysed and reported. Pathogens were isolated from between 26.8–65.6% of cases, with an overall isolation rate of 55.7% (95% CI, 48.2–62.9%). Isolation rates were highest amongst adult cases followed by children, and the odds of isolating a pathogen was greater in diarrhoeal cases (Odds Ratio 4.93 (95% CI, 1.99 to 12.23), than in asymptomatic controls. Overall isolation ranged from 8% to 99%; and heterogeneity testing suggests differences between age groups (Q=5.806; df=2, P=0. 055). Mixed E. coli spp., (29.95%), Cryptosporidium (21.52%), Cyclospora (18%), Entamoeba. (13.8%), Shigella spp. (10.49%), Salmonella spp. (8.36%), and Campylobacter spp. (8.33%), were most commonly reported, and rotavirus was the most common virus isolated. This is the first review to look at the range of enteric pathogens circulating in SSA, and has confirmed high rates of isolation of pathogens from diarrhoeal cases. Public health practitioners can use this information to understanding the challenges related to diarrhoeal illness and set priorities for their prevention and control.

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“…In Dutta et al study, Grade II-IV was observed in 70.8% of all cases of persistent diarrhoea. 5 In present study, it was 65.71%. Under nutrition was common in male children (87.18%) when compared to female children (83.87%).…”

Section: Discussionmentioning

confidence: 66%

“…1 Dutta et al in their study also concluded that children aged between 7 and 18 months had increased incidence of persistent diarrhoea. 5 Persistent diarrhoea was observed in 55.71% male children and 44.29% female children, with slight male preponderance. This was similar to the study done by Mbori-Ngacha et al 6 Under nutrition was observed in 85.71% of all cases of persistent diarrhea.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and risk factors for persistent diarrhoea in children under five years of age in an urban referral centre

Durairaj¹,

Raju²,

Thirumalaikumarasamy³

2017

Int J Contemp Pediatr

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Background: Persistent diarrhoea is a known cause of childhood mortality, morbidity and malnutrition in developing countries. The present study was conducted with the aim to study the clinical profile of persistent diarrhoea in children under 5 years of age and to find the possible host and environmental risk factors associated with persistent diarrhoea.Methods: The present descriptive study was conducted on 70 children with persistent diarrhoea, between age of 1 month and 5 years who admitted to DTTU, ICH & HC, Chennai during the period from February 2005 to September 2006. Detailed history was elicited from the parents usually mother regarding illness and risk factors were noted. The children were subjected to detailed clinical examination to assess dehydration, malnutrition, parenteral infections, and nutritional status. Univariable and multivariable logistic regression analyses were used to find risk factors associated with the incidence of diarrhoea.Results: Most of the children (35.71%) were under the age of 6 months to one year. Male (55.71%) children are more affected than female (44.29%) children. Undernutrition was observed in 85.71% of cases. Parenteral infection (44.28%) was noticed as major risk factor among children. E. coli was the organism isolated from stool culture in about 73.91% of cases with gut infection. The total fatality rate in the study population was 10%. Multivariable regression revealed significant associations between persistent diarrhoeal disease in children and protein energy malnutrition (OR- 1.812; 95% CI- 1.406-2.335), irrational antibiotic use (OR- 2.414; 95% CI- 1.195-4.877), parenteral infection (OR- 2.275; 95% CI-1.165-4.443) and use of unsafe drinking water (OR- 2.738; 95% CI- 1.221-6.143) and were found to be independent risk factors. Other factors found to be insignificant.Conclusion: The results of the study conclude that protein energy malnutrition, irrational antibiotic use, use of unsafe drinking water and parenteral infections are the significant risk factors for the incidence of diarrhea in the present study population. Hence, it is important to increase the awareness in parents regarding nutrition and safe drinking water use for children. Prompt diagnosis and appropriate treatment by the doctors can decrease the fatality rates.

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Prospective hospital based study on persistent diarrhoea.

Cited by 14 publications

References 8 publications

Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

Prevalence of gastrointestinal pathogens in Sub-Saharan Africa: systematic review and meta-analysis

Clinical profile and risk factors for persistent diarrhoea in children under five years of age in an urban referral centre

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