“…6,10 Molecular and epidemiologic studies suggest that HPV-positive OPSCC comprise a distinct disease entity, which has a better prognosis. 3,4,9,[11][12][13][14][15][16][17][18][19][20][21][22][23] Immunohistochemistry using p16 has been used as a surrogate marker of oncogenic HPV and is now widely accepted. 24 Currently, HPV-related cancers are one of the most important topics discussed in oncology, as HPV is a wellestablished etiological factor in carcinomas of the cervix, vulva, anus, and penis.…”