Prospective Function of Placental Leptin at Maternal–Fetal Interface

Bajoria, Rekha; Sooranna, Suren R.; Ward, Barbara J.; Chatterjee, Ratna

doi:10.1053/plac.2001.0769

Cited by 99 publications

(88 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deregulation of the autocrine/ paracrine function of leptin at the feto-placentomaternal interface may be implicated in the pathogenesis of GDM, preeclampsia, and intrauterine fetal growth restriction [112,113], as described in the next section.…”

Section: Role Of Leptin In Placentationmentioning

confidence: 99%

“…In fact, insulin is an inducer of leptin production in human placenta as shown in vivo [84], enhancing the activity of leptin promoter region [85]. This may be relevant in gestational diabetes [6,86,112,127], a state of greater insulin resistance and hyperinsulinemia than normal pregnancies. In this line, numerous studies have reported that circulating leptin levels, as well as placental leptin and LEPR expression are significantly higher in pregnant women with GDM compared to healthy control women with uncomplicated pregnancy [128,129], providing, at least, a molecular mechanism for the placenta overgrowth previously observed in GDM [99,100].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

115

View full text Add to dashboard Cite

Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

show abstract

Section: Role Of Leptin In Placentationmentioning

confidence: 99%

Section: Role Of Leptin In Pregnancymentioning

confidence: 99%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

115

View full text Add to dashboard Cite

show abstract

“…1, 2) were associated with relative immaturity of vessels of the placental villi, as determined by reduced or no immunohistochemical expression of von Willebrand factor and calponin (Figs. [3][4][5][6], 79 a marker of late differentiation in vascular smooth muscle cells. 56 Placental vasculogenesis was significantly reduced as indicated by lack of CD34 expression by individual foetal blood vessels, 79 similar to the abnormal placental vasculogenesis observed with spontaneous abortions in humans.…”

Section: Morphologic Pathology Of Scnt Placentaementioning

confidence: 99%

“…86 In humans, low placental and cord blood levels of leptin are observed in fetal growth retardation cases. 5 In mice, placentomegaly also has been related to an increased placental concentration of insulin-like growth factor 2 (IGF2), a cytokine promoting cellular mitosis, differentiation, and migration. 30 Strong support for the importance of IGF2 is provided by the findings of small placentae in Ig f 2 knockout mice and enlarged placentae in IGF2-overexpressing mice.…”

Section: Pathogenesismentioning

confidence: 99%

Review Paper: A Review of the Pathology of Abnormal Placentae of Somatic Cell Nuclear Transfer Clone Pregnancies in Cattle, Sheep, and Mice

et al. 2008

View full text Add to dashboard Cite

Abstract. Cloning of cattle, sheep, and mice by somatic cell nuclear transfer (SCNT) can result in apparently healthy offspring, but the probability of a successful and complete pregnancy is less than 5%. Failures of SCNT pregnancy are associated with placental abnormalities, such as placentomegaly, reduced vascularisation, hypoplasia of trophoblastic epithelium, and altered basement membrane. The pathogenesis of these changes is poorly understood, but current evidence implicates aberrant reprogramming of donor nuclei by the recipient oocyte cytoplast, resulting in epigenetic modifications of key regulatory genes essential for normal placental development. The purpose of this review is to provide an overview of the anatomic pathology of abnormal placentae of SCNT clones and to summarize current knowledge concerning underlying pathogenetic mechanisms.

show abstract

“…Proposed roles for this multifaceted polypeptide include regulating trophoblast invasion and endocrinology, fetal and placental growth, angiogenesis, hematopoiesis, fetal bone development, and the maturation of the fetal immune system. Indeed, acting via autocrine and/or paracrine mechanisms, leptin may be an important factor in the maintenance of pregnancy itself (Bajoria et al 2002, Henson & Castracane 2002, Sagawa et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Henson

Swan²,

Edwards³

et al. 2004

Reproduction

View full text Add to dashboard Cite

Leptin produced by both adipose tissue and the placental trophoblast, has been proposed to regulate numerous aspects of human conceptus development. Although recent animal studies have suggested an additional role for the polypeptide in fetal lung maturation, no evidence has been reported in primates. Therefore, we employed the baboon (Papio sp.), a well-characterized primate model for human pregnancy, to determine the presence and ontogeny of leptin receptor in fetal lung with advancing gestation. Lungs were collected from fetal baboons, early in gestation (days 58-62, n 5 4), at mid gestation (days 98 -102, n 5 4), and late in gestation (days 158 -165, n 5 4) (term 184 days). mRNA transcripts for leptin (LEP) and both long and short intracellular domain isoforms of the leptin receptor (LEP-R L and LEP-R S ) were assessed by RT-PCR. leptin receptor protein was evaluated by immunoblotting and cell types expressing leptin receptor were identified in late pregnancy by immunohistochemistry. Fetal serum leptin concentrations, determined by RIA, remained relatively unchanged at 5.7 6 1.1 ng/ml (mean 6 S.E.M.) in mid pregnancy and 8.4 6 3.0 ng/ml in late pregnancy (P > 0.05). Although leptin were detectable in fetal lung, no changes in transcript abundance were apparent with advancing gestation. However, transcripts for both LEP-R L and LEP-R S receptor isoforms increased several-fold (P < 0.05) in fetal lung between mid and late gestation, while leptin receptor protein was detectable only in late pregnancy. leptin receptor was localized in distal pulmonary epithelial cells, including type II pneumocytes. In conclusion, leptin is present in the fetal baboon and its receptor is enhanced during late gestation in cells responsible for the synthesis of pulmonary surfactant. Collectively, these and past findings may suggest a modulatory role for the polypeptide in pulmonary development and/or may identify leptin receptor as a physiological marker of primate fetal lung maturity.

show abstract

Prospective Function of Placental Leptin at Maternal–Fetal Interface

Cited by 99 publications

References 123 publications

Role of leptin in female reproduction

Role of leptin in female reproduction

Review Paper: A Review of the Pathology of Abnormal Placentae of Somatic Cell Nuclear Transfer Clone Pregnancies in Cattle, Sheep, and Mice

Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy

Contact Info

Product

Resources

About