Prospective Evaluation of Urinary Amylase Test Strip

Gunn, I R; Faye, Samba Thiapato; Clayton, Mitchell

doi:10.1016/s0140-6736(86)91878-7

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…The detection limit of about 2000 U of amylase per liter has been considered to result in a fairly low sensitivity. 8,9 Trypsinogen is a 25-kd pancreatic proteinase. The two main isoenzymes, (cationic) trypsinogen-1 and (anionic) trypsinogen-2, are secreted at high concentrations into pancreatic fluid, but a small proportion escapes into the circulation.…”

Section: Discussionmentioning

confidence: 99%

Rapid Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis

et al. 1997

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Section: Discussionmentioning

confidence: 99%

Rapid Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis

et al. 1997

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“…Urine amylase has shown high sensitivity in a diagnosis of acute pancreatitis in the past (Level 2b) [41]. However, comparison with blood amylase and other blood pancreatic enzymes found that, at present, measurements of urine amylase have no superiority in diagnostic ability to measurements of other blood pancreatic enzymes (Level 2b–3b) [42, 43].…”

Section: Introductionmentioning

confidence: 99%

New diagnostic criteria of acute pancreatitis

Kiriyama

Gabata

Takada

et al. 2009

J Hepato Biliary Pancreat

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Practical guidelines for the diagnosis of acute pancreatitis are presented so that a rapid and adequate diagnosis can be made. When acute pancreatitis is suspected in patients with acute onset of abdominal pain and tenderness mainly in the upper abdomen, the diagnosis of acute pancreatitis is made on the basis of elevated levels of pancreatic enzymes in the blood and/or urine. Furthermore, other acute abdominal diseases are ruled out if local findings associated with pancreatitis are confirmed by diagnostic imaging. According to the diagnostic criteria established in Japan, patients who present with two of the following three manifestations are diagnosed as having acute pancreatitis: characteristic upper abdominal pain, elevated levels of pancreatic enzymes, and findings of ultrasonography (US), CT or MRI suggesting acute pancreatitis. Detection of elevated levels of blood pancreatic enzymes is crucial in the diagnosis of acute pancreatitis. Measurement of blood lipase is recommended, because it is reported to be superior to all other pancreatic enzymes in terms of sensitivity and specificity. For measurements of the blood amylase level widely used in Japan, it should be cautioned that, because of its low specificity, abnormal high values are also often obtained in diseases other than pancreatitis. The cut-off level of blood pancreatic enzymes for the diagnosis of acute pancreatitis is not able to be set because of lack of sufficient evidence and consensus to date. CT study is the most appropriate procedure to confirm image findings of acute pancreatitis. Elucidation of the etiology of acute pancreatitis should be continued after a diagnosis of acute pancreatitis. In the process of the etiologic elucidation of acute pancreatitis, judgment whether it is gallstone-induced or not is most urgent and crucial for deciding treatment policy including the assessment of whether endoscopic papillary treatment should be conducted or not. The diagnosis of gallstone-induced acute pancreatitis can be made by combining detection of elevated levels of bilirubin, transamylase (ALT, AST) and ALP detected by hematological examination and the visualization of gallstones by US.

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Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis

Rompianesi

Hann

Komolafe

et al. 2017

Cochrane Database of Systematic Reviews

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As about a quarter of people with acute pancreatitis fail to be diagnosed as having acute pancreatitis with the evaluated tests, one should have a low threshold to admit the patient and treat them for acute pancreatitis if the symptoms are suggestive of acute pancreatitis, even if these tests are normal. About 1 in 10 patients without acute pancreatitis may be wrongly diagnosed as having acute pancreatitis with these tests, therefore it is important to consider other conditions that require urgent surgical intervention, such as perforated viscus, even if these tests are abnormal.The diagnostic performance of these tests decreases even further with the progression of time, and one should have an even lower threshold to perform additional investigations if the symptoms are suggestive of acute pancreatitis.

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Prospective Evaluation of Urinary Amylase Test Strip

Cited by 10 publications

References 3 publications

Rapid Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis

Rapid Measurement of Urinary Trypsinogen-2 as a Screening Test for Acute Pancreatitis

New diagnostic criteria of acute pancreatitis

Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis

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