Prospective evaluation of transnasal esophagogastroduodenoscopy: feasibility and study on performance and tolerance

Office-Based Ultrathin Esophagogastroduodenoscopy in a Primary Care Setting

“…16 Other studies have reported on the adequacy of biopsy size for pathologic diagnosis. 17,18 Our study had several limitations: there was high percentage of women, 1 endoscopist performed all u-EGD procedures, and it was conducted in a university family medicine residency training site in the southeastern United States. Each of these limitations may decrease the generalizability of our results.…”

Comparison of Peroral Versus Ultrathin Transnasal Endoscopy in the Diagnosis of Upper Gastrointestinal Pathology

“…9 Since a procedure may be deemed incomplete in a situation where biopsies have not been taken, it was felt essential to study this parameter of TNEGD concomitantly. Having matched the parameters in the two arms of the study and removing operator bias by blinding the histopathologist to the actual procedure being done, we proceeded to evaluate the efficacy of the transnasal route for obtaining biopsy tissue.…”

“…Failure of intubation has been reported before and has ranged between 12% to 18%. [7][8][9] Reasons for this include difficulty in traversing the nasal passage for anatomical reasons, and possible psychological factors leading to intolerance. In our study, there were no failures in the TNEGD group, and this may be related to the exclusion of patients with nasal or sinus problems.…”

“…10 An estimation of patient-tolerance and acceptability has also been shown to be higher for transnasal endoscopy. 9,10 However, the endoscopist's opinion, from a technical standpoint in past studies, has not been entirely favorable for the transnasal route owing to the limitations imposed by the inadequate lens clearing, suctioning, air insufflation, and looping. 7,9,10 All these problems were related to the instrument itself rather than the actual procedure.…”

“…Since then, various investigators have reported on the use of ultrathin gastroscopes for the transnasal approach. [7][8][9] Initial reports have been encouraging on utilizing this route for diagnostic EGD. Nevertheless, concerns remain on the ability to obtain tissue biopsy, since this, along with adequate visualization, has become a parallel necessity for endoscopy.…”