Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

Cantisani, Vito; David, Emanuele; Virgilio, Armando De; Sidhu, Paul S.; Grazhdani, Hektor; Greco, Antonio; Vincentiis, Marco de; Corsi, Alessandro; Cristofaro, Flaminia De; Brunese, Luca; Calliada, Fabrizio; Blandino, Alfredo; Tombolini, Mario; Ascenti, Giorgio; Stramare, Roberto; Caratozzolo, M; Dambrosio, F

doi:10.11152/mu-923

Cited by 16 publications

(25 citation statements)

References 35 publications

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“…Quantitative and shear wave elastography may be promising for differentiation and characterization. Cantisani et al assessed 63 parotid tumors by using the semiquantitative technique for stiffness evaluation. They measured the elasticity indexes and reported that mean elasticity was statistically significant between benign and malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

The Role of Real‐Time Elastography in the Differential Diagnosis of Salivary Gland Tumors

Karaman

Başak

Polat

et al. 2018

J of Ultrasound Medicine

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Objectives-The aim of the study was to scrutinize the value of qualitative elastography in the diagnosis of salivary gland masses.Methods-Sixty patients were enrolled in this prospective study. Patients aged between 1 and 91 years (mean age, 48.8 ± 20.48) with a salivary gland mass were studied with real-time elastography. All patients were examined by 1 examiner, blinded to all relevant data. On elastography, masses were scored into 4 types according to their stiffness compared to normal tissue. Scores of 3 and 4 were accepted as signs of malignancy. Sensitivity, specificity, and positive and negative predictive value were calculated for elastography in verifying malignancy.Results-Forty-two percent of the masses were located in the parotid, and the rest in submandibular gland. The diameter of the lesions varied between 12 and 60 mm (mean, 24.36 ± 11.98 mm). Forty-four masses were benign (73%), and among them the majority were inflammatory lesions (31 of 60; 51.7%). There were 16 malignant lesions (27%). On elastography, not only all malignant lesions but 15 benign lesions were scored as 3 to 4. All masses scored as 1 to 2 were benign. Sensitivity was 100%; specificity, 66%; positive predictive value, 52%; and negative predictive value, 100%. When only Score 4 lesions were accepted as malignant, these values became 75%, 77%, 55%, and 90%, respectively.Conclusions-Elastography alone cannot be used to discriminate malignant from benign in the evaluation of salivary gland lesions. However, with its high negative predictive value, it may be used as an adjunct tool to increase the diagnostic value of ultrasonography.

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Section: Discussionmentioning

confidence: 99%

The Role of Real‐Time Elastography in the Differential Diagnosis of Salivary Gland Tumors

Karaman

Başak

Polat

et al. 2018

J of Ultrasound Medicine

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“…Klintworth et al 2012 [8] Yerli et al 2012 [24] Badea et al 2013 [16] Celebi and Mahmutoglu 2013 [17] Wierzbicka et al 2013 [19] Yu et al 2016 [20] Altinbas et al 2017 [15] Cantisani et al 2017 [7] Herman et al 2017 [6] Mansour et al 2017 [18] 1: Was the spectrum of patient representative of the patients who will receive the test in practice? Recently, several original studies have focused on the value of sonoelastography for differentiating between malignant and benign parotid lesions.…”

Section: Quadas Questionnairementioning

confidence: 99%

“…In addition, haemorrhage and calcification in benign tumours may result in a heterogeneous appearance that resembles a malignancy [1][2][3][4][5]. Although ultrasound-guided fine-needle aspiration cytology (FNAC) is considered the gold standard for preoperative diagnosis [6], it is an invasive method and, as a general rule, non-invasive methods are preferred when the results are similar [7]. Sonoelastography is an innovative diagnostic imaging tool that assesses tissue stiffness [8].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, numerous studies have been published on the role of sonoelastography for differentiating between malignant and benign parotid lesions. However, there are large differences in the results, with a sensitivity ranging from 40% to 100% and a specificity ranging from 26% to 97% [7,8,[15][16][17][18][19][20]. Therefore, this study aimed to assess the performance of sonoelastography for differential diagnosis between malignant and benign parotid lesions using a meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis

Zhang

Wang

et al. 2018

Eur Radiol

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Objectives To assess the performance of sonoelastography for differential diagnosis between malignant and benign parotid lesions using a meta-analysis. Methods An independent literature search of English medical databases, such as PubMed, Embase and Medline (Embase.com), Web of Science, Cochrane Library and Ovid was performed. The diagnostic accuracy of sonoelastography was compared with that of histopathology and/or cytology, which was used as reference standard. The pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the curve (AUC) were calculated to evaluate the accuracy of sonoelastography. A meta-regression analysis evaluating imaging mechanisms, shear wave elastography techniques, assessment methods and QUADAS scores was performed.Results Ten eligible studies that included a total sample of 711 patients with 725 parotid lesions were included. Sonoelastography showed a pooled sensitivity of 0.67 (95% CI 0.59-0.74), specificity of 0.64 (95% CI 0.60-0.68), DOR of 8.00 (95% CI 2.96-21.63) and an AUC of 0.77. The results of the meta-regression analysis revealed that no heterogeneity was due to the imaging mechanism (p = 0.119), shear wave elastography technique (p = 0.473) or QUADAS score (p = 0.462). However, the assessment method was a significant factor that affected the study heterogeneity (p = 0.035). According to the subgroup analysis, quantitative and semiquantitative methods performed better than qualitative ones. Conclusion Overall, sonoelastography has a limited value for differential diagnosis between malignant and benign parotid lesions. Quantitative and semiquantitative methods perform better than qualitative ones. Key Points • Overall, sonoelastography has a limited value for differential diagnosis between malignant and benign parotid lesions.• Quantitative and semiquantitative assessment methods perform better than qualitative ones.• Semiquantitative and quantitative methods are automatically calculated by an ultrasound machine and are thus less operator-dependent.

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“…No external compression with the transducer was needed as Elastoscan uses the pulsations of the carotid artery (in vivo compression) for the elastography response. 5 Patient is instructed to hold breath and swallowing for 10-15 seconds during scan. 6 The image is paused after all the colour bar turned green.…”

Section: Protocol For Thyroid Elastographymentioning

confidence: 99%

Elastography evaluation of normal thyroid gland and its comparison with diffuse non nodular enlarged thyroid gland using strain ultrasound elastography

et al. 2019

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Background: The thyroid gland is located in the anterior part of neck, spanning between C5 and T1 vertebra and is located anterior to the thyroid and cricoids cartilage of larynx and first three tracheal rings. Ultrasonography has been widely used for diagnosis of thyroid disease it is highly regarded for its ease of use, real-time capability, portability and low cost.Methods: The current observational study was conducted in Department of Radiology, Dr. BRAM Hospital, Pt. JNM Medical College, Raipur, India. Consecutive sampling method was used for the study. All the cases coming to radiology department during the study period were taken as study subjects.Results: Of the normal subjects, author found 107 normal thyroid subjects and 53 patients were categorized into cases with diffuse non-nodular thyroid swelling groups. Of the diffuse thyroid swelling group about 85% of the study population is between 20-50 years of age group, 13.2% were <20 years of age and one patient is >50 years of age. Females to male ratio for diffuse thyroid disease is 3.4:1.Conclusions: Ultrasound elastography (USE) is a newly developed non-invasive method to evaluate and compare the elasticity of the thyroid gland and other organs like liver, prostate, parotid, breast pathologies. Its use is based on the principle that pathological changes in a tissue also changes its elasticity.

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Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

Cited by 16 publications

References 35 publications

The Role of Real‐Time Elastography in the Differential Diagnosis of Salivary Gland Tumors

The Role of Real‐Time Elastography in the Differential Diagnosis of Salivary Gland Tumors

Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis

Elastography evaluation of normal thyroid gland and its comparison with diffuse non nodular enlarged thyroid gland using strain ultrasound elastography

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