Prospective evaluation of nutritional status related to body mass indices and outcomes after modified D2 gastrectomy for carcinoma

Murphy, P.; Blackshaw, Guy; Paris, Holly J.; Edwards, Paul A.W.; Barry, Jonathan; Lewis, Wyn G.

doi:10.1016/j.clnu.2003.07.009

Cited by 20 publications

(16 citation statements)

References 20 publications

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“…Yoshikawa et al [17] reported that the incidence of postoperative complications, and mean blood loss of an obese group were significantly higher than those of a normal group. Murphy et al [18] reported that underweight patients experience delays in recovery of their nutritive condition after a surgical operation and that overweight patients with a BMI ≥ 30 kg/m 2 have a high incidence of complications. Therefore, it is very important to maintain a normal BMI in patients with gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea

2012

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This study was conducted to identify dietary factors that may affect the occurrence of gastric cancer in Koreans. Preoperative daily nutrition intake and diet quality of patients diagnosed with gastric cancer were evaluated. Collected data were comparatively analyzed by gender. The results were then used to prepare basic materials to aid in the creation of a desirable postoperative nutrition management program. The subjects of this study were 812 patients (562 men and 250 women) who were diagnosed with gastric cancer and admitted for surgery at Soonchunhyang University Hospital between January 2003 and December 2010. Nutrition intake and diet quality were evaluated by the 24-hr recall method, the nutrient adequacy ratio, mean adequacy ratio (MAR), nutrient density (ND), index of nutritional quality (INQ), dietary variety score (DVS), and dietary diversity score (DDS). The rate of skipping meals and eating fast, alcohol consumption, and smoking were significantly higher in males than those in females. The levels of energy, protein, fat, carbohydrate, phosphorous, sodium, potassium, vitamin B1, vitamin B2, niacin, and cholesterol consumption were significantly higher in males than those in females. Intake of fiber, zinc, vitamin A, retinol, carotene, folic acid were significantly higher in females than those in males. MAR in males was significantly higher (0.83) than that in females (0.79). INQ values were higher in females for zinc, vitamin A, vitamin B2, vitamin B6, and folic acid than those in males. The average DVS was 17.63 for females and 13.19 for males. The average DDS was 3.68 and the male's average score was 3.44, whereas the female's average score was 3.92. In conclusion, males had more dietary habit problems and poor nutritional balance than those of females. Our findings suggest that proper nutritional management and adequate dietary education for the primary prevention of gastric cancer should be emphasized in men.

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Section: Discussionmentioning

confidence: 99%

Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea

2012

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“…Low body mass index and anemia, as in previous studies, are likely to reflect the presence of general poor health or a more advanced stage of preexisting malignancy status. 19 -22 Low body mass index has been described as a marker of patients who are more likely to have advanced disease including esophageal, 20 gastric, 21 and lung 22 cancers. Anemia has also been shown prospectively to be associated with increased risk for perioperative infection and adverse outcome in surgical patients.…”

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confidence: 99%

Bispectral Index Monitoring, Duration of Bispectral Index Below 45, Patient Risk Factors, and Intermediate-term Mortality after Noncardiac Surgery in the B-Unaware Trial

Kertai

Palanca²,

Pal³

et al. 2011

Anesthesiology

127

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Background: Postoperative mortality has been associated with cumulative anesthetic duration below an arbitrary processed electroencephalographic threshold (bispectral index [BIS] Ͻ45). This substudy of the B-Unaware Trial tested whether cumulative duration of BIS values lower than 45, cumulative anesthetic dose, comorbidities, or intraoperative events were independently associated with postoperative mortality. Methods: The authors studied 1,473 patients (mean Ϯ SD age, 57.9 Ϯ 14.4 yr; 749 men) who underwent noncardiac surgery at Barnes-Jewish Hospital in St. Louis, Missouri. Multivariable Cox regression analysis was used to determine whether perioperative factors were independently associated with all-cause mortality. Results: A total of 358 patients (24.3%) died during a follow-up of 3.2 Ϯ 1.1 yr. There were statistically significant associations among various perioperative risk factors, including malignancy and intermediate-term mortality. BIS-monitored patients did not have lower mortality than unmonitored patients (24.9 vs. 23.7%; difference ϭ 1.2%, 95% CI, Ϫ3.3 to 5.6%). Cumulative duration of BIS values less than 45 was not associated with mortality (multivariable hazard

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“…In any case, diminished nutritional status may worsen the prognosis of any patient with a serious illness, including gastric cancer. The association between BMI and long-term outcome has been investigated with regard to certain malignancies (43,44), including a number of controversial studies evaluating BMI and GC prognosis (23)(24)(25)(26)(27)(28). In the present study, preoperative and postoperative BMI of patients with stage II/III GC were evaluated, although no association between BMI and survival rates was identified.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, the preoperative prognostic nutritional index (PNI) as a reflection of the immunological and nutritional condition of the patients has been associated with the outcomes of patients who undergo gastrectomy for a number of stages of GC (10,11,16,17). Although the association between body mass index (BMI) and postoperative complications has been investigated (18)(19)(20)(21)(22), the association between BMI and long-term survival subsequent to curative gastrectomy remains unclear (23)(24)(25)(26)(27)(28) In the present study, the dose-response effects of S-1 ACT on survival in patients who received gastrectomy for GC were clarified, and other clinical factors that affected their survival were analyzed, including BMI and PNI as nutritional parameters.…”

Section: Introductionmentioning

confidence: 99%

Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S-1 adjuvant chemotherapy

et al. 2017

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Abstract. Predictors of survival in patients with stage II/III gastric cancer (GC) who received tegafur/gimeracil/oteracil (S-1) adjuvant chemotherapy (ACT) subsequent to gastrectomy were examined. Additionally, the association between dose intensity of S-1 and survival rate was investigated. A total of 62 patients with stage II/III gastric cancer were retrospectively evaluated, each of whom had received a curative D2 gastrectomy and S-1 ACT. The relative performance (RP; administered/planned S-1 doses x100%), body mass index (BMI), prognostic nutritional index (PNI) and body weight (BW) were calculated, and the association of survival with these factors and other clinicopathological parameters was examined. The 1-year treatment continuation rate for S-1 was 94.2%, excluding patients who experienced cancer recurrences during their ACT year. The initial S-1 reduction rate was 38.7%. Patients with stage II/IIIA disease exhibited significantly improved 5-year overall survival rates compared with patients with stage IIIB GC, 81.6/73.7 vs. 33.8% (P<0.01). No association between RP and survival was observed. BMI, BW and PNI were significantly decreased following surgery compared with preoperative states. In the univariate analysis, postoperative BW loss (BMI loss), pathological stage and >7 lymph node metastases were significantly associated with outcome (P<0.05); in the multivariate analysis, postoperative BW loss >10.6% and pathological stages were independent prognostic factors for survival. Continuing S-1 ACT for the full year exhibited a greater effect on survival compared with dosage. Early postoperative nutritional deterioration may decrease the survival rates in these patients.

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Prospective evaluation of nutritional status related to body mass indices and outcomes after modified D2 gastrectomy for carcinoma

Cited by 20 publications

References 20 publications

Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea

Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea

Bispectral Index Monitoring, Duration of Bispectral Index Below 45, Patient Risk Factors, and Intermediate-term Mortality after Noncardiac Surgery in the B-Unaware Trial

Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S-1 adjuvant chemotherapy

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