Prospective Evaluation of Household Contacts of Persons with Hantavirus Cardiopulmonary Syndrome in Chile

Ferrés, Marcela; Vial, Pablo; Marco, C; Yañez, Lia; Godoy, Paula; Castillo, Claudia; Hjelle, Brian; Delgado, Iris; Lee, Sang‐Joon; Mertz, Grégory

doi:10.1086/516786

Cited by 132 publications

(170 citation statements)

References 21 publications

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“…However, ANDV is the only hantavirus in which person-to-person transmission, primarily in small clusters among sex partners and other close household contacts, also occurs. [6][7][8] The annual incidence of HCPS in Chile ranges from 0.2-0.5/ 100.000 inhabitants. Seventy percent of cases occur in men, and the median age is 32 with a range of 6 weeks to 80 y.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile

Valdivieso

González

Nájera

et al. 2017

Human Vaccines & Immunotherapeutics

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Andes hantavirus cardiopulmonary syndrome, transmitted by Oligoryzomys longicaudatus, has no approved treatment, a case fatality rate of 35%, and documented person-to-person transmission. An Andes vaccine, highly needed for prevention, is in development. We aimed to evaluate knowledge, attitudes and practices (KAP) regarding hantavirus disease and willingness to participate in a future Andes vaccine trials through a cross sectional face-to-face oral survey of a randomly selected adult sample from 2 rural communes in southern Chile. Human subjects approval was obtained from our institutional IRBs, and participants signed informed consent. We enrolled 319 subjects from Corral and 321 from Curarrehue; 98% had heard about hantavirus disease and its reservoir but only half knew about transmission, symptoms and prevention. Participants fear the disease but are only partially aware of their own risk. One third of participants reported presence of rodents inside their homes. Despite moderate confidence in their health system, most subjects perceived vaccines as beneficial, and 93% would accept an approved hantavirus vaccine. Half would agree to participate in a vaccine trial and 29% would allow their children to participate. Motivations to participate were mainly altruistic, while risk perception was the main reason for declining. Knowledge about hantavirus disease and prevention practices require reinforcement, and a vaccine trial seems feasible in these populations.

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Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile

Valdivieso

González

Nájera

et al. 2017

Human Vaccines & Immunotherapeutics

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“…Esto puede explicarse por el largo período de incubación del SCHP y la alta movilidad actual de la población hacia zonas mineras, en las cuales hay una importante migración de habitantes originarios del sur de Chile, donde el virus Andes es endémico, los cuales potencialmente pueden presentar exposición e infección con el virus [6][7][8] . Cabe destacar que el paciente había visitado una zona urbana de Concepción y no se había trasladado a zonas rurales con riesgo de exposición al ratón coli-largo, dejando abierta la posibilidad de la transmisión de persona a persona, lo cual no fue documentado porque no se estudió al eventual caso índice.…”

Section: Discussionunclassified

“…El virus es eliminado por el ratón a través de sus secreciones (saliva, orina y heces) e ingresa al hombre por vía digestiva, cutánea o aérea, siendo esta última la más frecuente [1][2][3] . La transmisión de persona a persona está documentada, pero se considera excepcional [4][5][6] .…”

Section: Introductionunclassified

Primer caso de síndrome cardiopulmonar por hantavirus diagnosticado en la Región de Antofagasta, Chile

Zambrano¹,

Peralta²,

Carlaga³

2012

Rev. chil. infectol.

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Case Report: fi rst case of hantavirus cardiopulmonary syndrome diagnosed in the Second Region of Antofagasta Cases of Hantavirus cardiopulmonary syndrome (HCPS) have been reported in Chile between Region V and XI. In our country HCPS is caused by Andes virus. Hantavirus infection is acquired mainly through inhalation of aerosolized rodent fl uids. Person to person transmission is considered exceptional. The identifi ed rodent reservoir of the virus extends throughout Region III to XII, and no cases have been reported in the north of Chile. The incubation period is prolonged. We report the fi rst diagnosed patient with HCPS in the north of Chile. In this case we suggest the possibility of person to person transmission.

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“…This virus is located mainly in Argentina and Chile and has the particularity that it may spread through interhuman transmission. Further, it has been depicted as the only hantavirus for which an animal model with human-like disease is available (Ferres et al, 2007;Hooper et al, 2001;Martinez et al, 2005;Padula et al, 1998). The present work aims towards ANDV N protein immunodetection in infected cells by flow cytometry.…”

Section: Short Communicationmentioning

confidence: 99%

A rapid method for infectivity titration of Andes hantavirus using flow cytometry

Barriga¹,

Martínez-Valdebenito²,

Galeno³

et al. 2013

Journal of Virological Methods

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Prospective Evaluation of Household Contacts of Persons with Hantavirus Cardiopulmonary Syndrome in Chile

Abstract: In recent household contacts of persons with HCPS in Chile, the risk of HCPS was greatest among sex partners. Among the household contacts who developed HCPS, viremia preceded the onset of symptoms and the appearance of anti-hantavirus antibodies by up to 2 weeks.

Cited by 132 publications

References 21 publications

Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile

Knowledge, attitudes, and practices regarding hantavirus disease and acceptance of a vaccine trial in rural communities of southern Chile

Primer caso de síndrome cardiopulmonar por hantavirus diagnosticado en la Región de Antofagasta, Chile

A rapid method for infectivity titration of Andes hantavirus using flow cytometry

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