Prospective evaluation of delayed central nervous system (CNS) toxicity of hyperfractionated total body irradiation (TBI)

Neuropsychologic changes from before transplantation to 1 year in patients receiving myeloablative allogeneic hematopoietic cell transplant

“…Also important, 2 longitudinal studies with small samples have reported that no deterioration in function occurred after 1 year; however, this finding needs to be confirmed with larger cohorts. 3,5 The results of this study have major implications for advising health care professionals, patients, and their families about expectations after transplantation. Overall, patients and their families can be advised that, although short-term neurocognitive effects of HCT are severe, most patients return to their pretransplantation levels of cognitive function by 1 year after transplantation.…”

“…Memory, attention, and information-processing deficits have been documented. [1][2][3][4][5][6] Some recovery of cognitive function after transplantation has been suggested by studies that assessed patients 6 months or longer following HCT. 3,5,7 In parallel with neuropsychologic test results, numerous imaging studies have determined that neurologic changes such as cortical atrophy and ventricular enlargement occur in some patients after HCT conditioning chemotherapy or total body irradiation and that cyclosporine or tacrolimus treatments for graft-versus-host disease (GVHD) after HCT have neurotoxicities.…”

“…[1][2][3][4][5][6] Some recovery of cognitive function after transplantation has been suggested by studies that assessed patients 6 months or longer following HCT. 3,5,7 In parallel with neuropsychologic test results, numerous imaging studies have determined that neurologic changes such as cortical atrophy and ventricular enlargement occur in some patients after HCT conditioning chemotherapy or total body irradiation and that cyclosporine or tacrolimus treatments for graft-versus-host disease (GVHD) after HCT have neurotoxicities. [8][9][10][11] However, we are aware of no prospective, longitudinal studies that have documented both decrements in cognitive function and recovery following HCT and that have adequate power to permit conclusions about long-term neurocognitive outcomes after HCT.…”

Prospective Neurocognitive Function Over 5 Years After Allogeneic Hematopoietic Cell Transplantation for Cancer Survivors Compared With Matched Controls at 5 Years

“…1,2 Myeloablative conditioning followed by hematopoietic cell transplantation (HCT) is among the more neurotoxic cancer treatments, with acute deficits documented in memory, attention, and informationprocessing speed. [7][8][9][10][11] Research that has assessed patients 6 months or longer post-HCT indicates some recovery of cognitive function after acute deficits. [7][8][9][11][12][13][14][15] However, to our knowledge, no prospective studies have followed HCT patients beyond 2 years after transplantation.…”

“…[7][8][9][10][11] Research that has assessed patients 6 months or longer post-HCT indicates some recovery of cognitive function after acute deficits. [7][8][9][11][12][13][14][15] However, to our knowledge, no prospective studies have followed HCT patients beyond 2 years after transplantation.…”