Prospective evaluation of basal stromal Doppler studies in women with good ovarian reserve and infertility undergoing in vitro fertilization–embryo transfer treatment: patients with polycystic ovary syndrome versus ovulatory patients

Younis, Johnny S.; Jadaon, Jimmy E.; Haddad, Sami; Izhaki, Ido; Ben‐Ami, Moshe

doi:10.1016/j.fertnstert.2011.01.007

Cited by 23 publications

(15 citation statements)

References 23 publications

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“…also reported PCOS and control patients undergoing conventional in vitro fertilization had similar pregnancy and live birth rates8. But others have been concerned that ARTs may decrease the quality of oocytes and delay the mutation process of oocytes in PCOS patients9101112. Previous studies used microarrays to analyze genes that are differentially expressed in cumulus cells (CCs) between PCOS patients and control patients.…”

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confidence: 99%

Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients

Liu

Feng

et al. 2016

Sci Rep

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Polycystic ovary syndrome (PCOS) is a common frequent endocrine disorder among women of reproductive age. Although assisted reproductive techniques (ARTs) are used to address subfertility in PCOS women, their effectiveness is not clear. Our aim was to compare transcriptomic profiles of oocytes and cumulus cells (CCs) between women with and without PCOS, and assess the effectiveness of ARTs in treating PCOS patients. We collected oocytes and CCs from 16 patients with and without PCOS patients to categorize them into 6 groups according to oocyte nuclear maturation. Transcriptional gene expression of oocyte and CCs was determined via single-cell RNA sequencing. The ratio of fertilization and cleavage was higher in PCOS patients than in non-PCOS patients undergoing ARTs, and there was no difference in the number of high-quality embryos between the groups. Differentially expressed genes including PPP2R1A, PDGFRA, EGFR, GJA1, PTGS2, TNFAIP6, TGF-β1, CAV1, INHBB et al. were investigated as potential causes of PCOS oocytes and CCs disorder at early stages, but their expression returned to the normal level at the metaphase II (MII) stage via ARTs. In conclusion, ARTs can improve the quality of cumulus-oocyte complex (COC) and increase the ratio of fertilization and cleavage in PCOS women.

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confidence: 99%

Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients

Liu

Feng

et al. 2016

Sci Rep

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“…Promising results have indicated that follicular PD studies are positively correlated with ovarian response and other markers of ovarian reserve, but not necessarily with clinical pregnancy after in vitro fertilisation / embryo transfer (IVF/ET), and not in women with polycystic ovarian syndrome …”

Section: Introductionmentioning

confidence: 99%

“…2 Promising results have indicated that follicular PD studies are positively correlated with ovarian response and other markers of ovarian reserve, but not necessarily with clinical pregnancy after in vitro fertilisation / embryo transfer (IVF/ET), 3 and not in women with polycystic ovarian syndrome. 4 Others have focused on the measurement, by 3D PD, of vascularity index (VI), flow index (FI) and vascularisation-flow index (VFI). 5 VI estimates the number of vessels in the measured volume, FI estimates the average flow rates through these vessels by measuring the intensity of the colour output and VFI is an aggregate measure of the two.…”

Section: Introductionmentioning

confidence: 99%

The effect of melatonin on ultrasound markers of follicular development: A double‐blind placebo‐controlled randomised trial

Fernando

Wallace

Rombauts

et al. 2019

Aust NZ J Obst Gynaeco

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Background Melatonin is a potent oxygen scavenger and is capable of altering blood flow in various vascular beds. Aims We aimed to determine the effect of melatonin on ovarian vascular indices during ovarian stimulation for in vitro fertilisation (IVF). Materials and Methods This is a pilot double‐blind placebo‐controlled randomised trial. Sixty‐nine women (mean age 35.8 ± 4.3 years) undergoing their first cycle of IVF were randomised to receive either placebo, 2, 4 or 8 mg of melatonin, twice a day. Each participant underwent a transvaginal ultrasound at days 6–10 assessing follicular number and size. The vascularisation index (VI), flow index (FI) and vascularisation‐flow index (VFI) were measured. These indices were then correlated with embryological outcomes. Informed consent was obtained from participants. This trial was registered with the Australia New Zealand Clinical Trials Registry (ACTRN12613001317785). Results The number of follicles did not differ between groups (P = 0.4). There were no differences in the VI (P = 0.4), FI (P = 0.1) or VFI (P = 0.3) in the right ovary or the FI (P = 0.3) or VFI (P = 0.3) in the left ovary between groups. When comparing placebo to any dose of melatonin, there were no differences in any measured parameter. While there was correlation between the number of follicles on ultrasound and all measured embryological outcomes, there was no correlation between ovarian vascular indices and these important clinical outcomes. Conclusions Melatonin does not appear to change ovarian vascular indices during ovarian stimulation. In addition, such vascular indices cannot predict the number or quality of oocytes or embryos obtained in an IVF cycle. These findings require confirmation in future larger studies.

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“…Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, affecting 5%–10% depending on the population [1–3]. According to the 2003 Rotterdam consensus [4], PCOS should be diagnosed on the basis of the presence of two of three criteria—oligo‐ovulation/anovulation, hyperandrogenism, and polycystic ovarian morphology on ultrasonography—after exclusion of other endocrine disorders.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures

Huang

Tal

et al. 2015

International Journal of Gynecology & Obstetrics

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Prospective evaluation of basal stromal Doppler studies in women with good ovarian reserve and infertility undergoing in vitro fertilization–embryo transfer treatment: patients with polycystic ovary syndrome versus ovulatory patients

Cited by 23 publications

References 23 publications

Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients

Single-cell analysis of differences in transcriptomic profiles of oocytes and cumulus cells at GV, MI, MII stages from PCOS patients

The effect of melatonin on ultrasound markers of follicular development: A double‐blind placebo‐controlled randomised trial

A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures

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